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Steps towards the use of adult stem cells for gene therapy
Date:10/13/2011

This research, published on Oct. 12 on the Nature review website, provides evidence of a major concept could pave the way for the future use of these stem cells to treat humans, through perspective gene therapies. For several years now, scientists have been able to produce cells with stem cell properties, by using specialized and mature cells from our body, such as skin cells. These 'iPS' stem cells are said to be "pluripotent': they can provide specialized cells, upon demand, with the same gene pool as the original cells. iPS cells represent a potential basis for the exploration of several therapeutic areas, particularly transplants or gene therapy. However, to date research conducted on these cells had not provided proof of their potential in vivo efficiency for the aforementioned types of use.

For the first time, researchers from the Sanger Institute and the University of Cambridge (United Kingdom), with collaboration from an Institut Pasteur/Inserm team in France, have demonstrated that the cells derived from iPS stem cells may be used within the framework of gene therapy to help counter pathological effects in a mice model with liver failure.

The researchers focussed on a rare genetic disease affecting the liver. It is caused by a point mutation in the a1-antitrypsin gene, which is essential for hepatic cells to function correctly. Children display varying degrees of mild symptoms (jaundice, abdomen distension, etc.), but, in adulthood, these symptoms may progressively develop into a pulmonary emphysema and cirrhosis, where the only hope of a cure is a liver transplant.

Researchers from the University of Cambridge, directed by Ludovic Vallier and David Lomas, and from the Sanger Institute, coordinated by Allan Bradley, began by sampling patients' skin cells, which were then cultured in vitro for "differentiation" before applying the properties of the pluripotent stem cells: this is the "iPS cells" stage. Through genetic
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Contact: Marion Doucet
marion.doucet@pasteur.fr
01-456-88928
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

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