Navigation Links
Steps towards the use of adult stem cells for gene therapy
Date:10/13/2011

This research, published on Oct. 12 on the Nature review website, provides evidence of a major concept could pave the way for the future use of these stem cells to treat humans, through perspective gene therapies. For several years now, scientists have been able to produce cells with stem cell properties, by using specialized and mature cells from our body, such as skin cells. These 'iPS' stem cells are said to be "pluripotent': they can provide specialized cells, upon demand, with the same gene pool as the original cells. iPS cells represent a potential basis for the exploration of several therapeutic areas, particularly transplants or gene therapy. However, to date research conducted on these cells had not provided proof of their potential in vivo efficiency for the aforementioned types of use.

For the first time, researchers from the Sanger Institute and the University of Cambridge (United Kingdom), with collaboration from an Institut Pasteur/Inserm team in France, have demonstrated that the cells derived from iPS stem cells may be used within the framework of gene therapy to help counter pathological effects in a mice model with liver failure.

The researchers focussed on a rare genetic disease affecting the liver. It is caused by a point mutation in the a1-antitrypsin gene, which is essential for hepatic cells to function correctly. Children display varying degrees of mild symptoms (jaundice, abdomen distension, etc.), but, in adulthood, these symptoms may progressively develop into a pulmonary emphysema and cirrhosis, where the only hope of a cure is a liver transplant.

Researchers from the University of Cambridge, directed by Ludovic Vallier and David Lomas, and from the Sanger Institute, coordinated by Allan Bradley, began by sampling patients' skin cells, which were then cultured in vitro for "differentiation" before applying the properties of the pluripotent stem cells: this is the "iPS cells" stage. Through genetic
'/>"/>

Contact: Marion Doucet
marion.doucet@pasteur.fr
01-456-88928
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Three steps to unbreakable bones on World Osteoporosis Day
2. Simple Safety Steps Can Make Back to School a Breeze
3. Steps Outlined to Screen All Newborns for Heart Defects
4. Kids Urged to Take Steps to Avoid Spreading Illness at School
5. Next steps for Tenofovir gel: CONRAD and TIA sign license agreement
6. Take Steps to Prevent Pulmonary Embolisms
7. Paraplegic man stands, steps with assistance and moves his legs voluntarily
8. Five Steps to a Healthier Heart
9. Early Steps Toward an Alzheimers Blood Test
10. Take Steps to Avoid Winters Indoor Allergies
11. A few steps could lead to big gains for hospitalized seniors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... 01, 2014 Cannabis use among young people ... 14 to 17 having used marijuana at least once and ... slogan “Say ‘No’ to Drugs, Say ‘Yes to Life,’ volunteers ... to youth this summer with factual information about drugs, to ... months, Hamburg “Say ‘No’ to Drugs, Say ‘Yes’ to Life,” ...
(Date:8/1/2014)... New York (PRWEB) August 01, 2014 ... protecting the rights of victims injured by defective medical ... it would be recalling its Ethicon surgical power morcellator ... device maker sited concerns involving the spread of cancer ... report dated July 31, 2014. , Johnson ...
(Date:8/1/2014)... In a first-of-its-kind study, researchers at University Hospitals ... lap infants may be at greater risk for death ... medical emergencies on flights worldwide between January 2010 and ... in children under the age of 2. , ... characterize the rare event of an in-flight pediatric fatality ...
(Date:8/1/2014)... and transgender individuals who want to conceive a child ... heterosexual and cisgendered peers, such as reduced fertility, but ... legal challenges to become parents. A comprehensive review of ... presented in the article " LGBT Assisted Reproduction: Current ... LGBT Health , a peer-reviewed journal from Mary ...
(Date:8/1/2014)... August 01, 2014 Hot off the presses ... spa category of the World’s Best Awards by Travel ... month-long celebration of National Relaxation Day (technically August 15). ... of MAJOR experts to help guests celebrate relaxation throughout the ... is for health and wellness to carve out time to ...
Breaking Medicine News(10 mins):Health News:Addressing a Serious Issue Affecting German Teens 2Health News:J&J's Ethicon Unit Recalls its Power Morcellator Devices After Warnings by Federal Regulators and Concern About Risk of Spreading Occult Cancer, Parker Waichman Comments 2Health News:J&J's Ethicon Unit Recalls its Power Morcellator Devices After Warnings by Federal Regulators and Concern About Risk of Spreading Occult Cancer, Parker Waichman Comments 3Health News:J&J's Ethicon Unit Recalls its Power Morcellator Devices After Warnings by Federal Regulators and Concern About Risk of Spreading Occult Cancer, Parker Waichman Comments 4Health News:New research characterizes in-flight pediatric deaths 2Health News:Advances in assisted reproduction create more options and new legal issues for LGBT couples 2Health News:The Lodge at Woodloch Kicks Off National Relaxation Day with a Month Long Celebration 2Health News:The Lodge at Woodloch Kicks Off National Relaxation Day with a Month Long Celebration 3Health News:The Lodge at Woodloch Kicks Off National Relaxation Day with a Month Long Celebration 4
... , SANTA CLARA, Calif., Nov. 23 NewCardio, Inc., ... that CEO, Dr. Branislav Vajdic, and CFO, Richard Brounstein, will present ... at 4:30 PM PST at the Luxe Sunset Hotel in Los ... Wednesday, December 2nd and Thursday, December 3rd. Please contact Brett ...
... ... Provider for its QlikView Business Intelligence Software , ... Radnor, PA (PRWEB) November 23, 2009 ... it was recognized with the Healthcare IT Innovation™ Award in the Best New ...
... , NORTH ANDOVER, Mass., Nov. 23 This time of ... and anxiety. Often these feelings, both positive and negative, translate into urges ... are lots of opportunities to do so all season long. ... of mom,s apple pie, but how many of us stop there? ...
... , ... Health of North America is offering FREE and Confidential HIV Testing services at its affiliated ... HIV TESTING SITE or call 1-877-966-3672 or 1-407-248-1644 (Main Office). , ... (Vocus) November 23, 2009 -- We are well ...
... The ... community of Cherry Hills Village, Denver, CO, by Absolute Auction December 3, 2009. ... Denver, Colo. (PRWEB) November 23, ... Hills Village in Denver, Colo., and you are immediately and keenly aware that no details ...
... , RSV found to cause far ... , BOSTON, Nov. 23 Influenza, particularly H1N1, has ... and the public. However, an analysis from Children,s Hospital Boston, ... several recent flu seasons, shows that another virus - respiratory ...
Cached Medicine News:Health News:NewCardio, Inc. to Present at 2nd Annual LD MICRO Conference 2Health News:NewCardio, Inc. to Present at 2nd Annual LD MICRO Conference 3Health News:QlikTech Wins Healthcare IT Innovation™ Award 2Health News:QlikTech Wins Healthcare IT Innovation™ Award 3Health News:QlikTech Wins Healthcare IT Innovation™ Award 4Health News:Tis' the Season to Eat and Eat More! 2Health News:,The Institute of Women's Health of North America Increases its Outreach by Offering Free and Confidential HIV Testing in Florida, 2Health News:,The Institute of Women's Health of North America Increases its Outreach by Offering Free and Confidential HIV Testing in Florida, 3Health News:,The Institute of Women's Health of North America Increases its Outreach by Offering Free and Confidential HIV Testing in Florida, 4Health News:Barbara Fentress, Designer of the Denver International Airport and Convention Center, Offers Her Private Mansion at Absolute Auction 2Health News:Amid the Flu Epidemic, Don't Forget RSV in Young Children 2Health News:Amid the Flu Epidemic, Don't Forget RSV in Young Children 3Health News:Amid the Flu Epidemic, Don't Forget RSV in Young Children 4
(Date:8/1/2014)... SAN DIEGO, Aug. 1, 2014 Arena ... provided a corporate update and reported financial results ... "We have continued to see ... including a 43% quarter-over-quarter increase in estimated total ... the 10,000 mark," said Jack Lief, Arena,s President ...
(Date:7/31/2014)...  Sorrento Therapeutics, Inc. (NASDAQ: SRNE ; Sorrento) ... Chief Business Officer and Executive Vice President. Mr. Singh died ... "Sorrento is deeply saddened and shocked by the ... go to Amar,s family and friends," said Henry Ji ... Mr. Singh joined Sorrento in January 2014 from Synta ...
(Date:7/31/2014)... July 31, 2014 Tandem Diabetes Care®, Inc. (NASDAQ: ... of the t:slim® Insulin Pump, today reported its financial results ... In comparing the second quarter of 2014 to the same ... $10.3 million from $5.5 million , t:slim Pump shipments ... In comparing six months ended June 30, 2014 to ...
Breaking Medicine Technology:Arena Pharmaceuticals Provides Corporate Update and Reports Second Quarter 2014 Financial Results 2Arena Pharmaceuticals Provides Corporate Update and Reports Second Quarter 2014 Financial Results 3Arena Pharmaceuticals Provides Corporate Update and Reports Second Quarter 2014 Financial Results 4Arena Pharmaceuticals Provides Corporate Update and Reports Second Quarter 2014 Financial Results 5Arena Pharmaceuticals Provides Corporate Update and Reports Second Quarter 2014 Financial Results 6Arena Pharmaceuticals Provides Corporate Update and Reports Second Quarter 2014 Financial Results 7Arena Pharmaceuticals Provides Corporate Update and Reports Second Quarter 2014 Financial Results 8Arena Pharmaceuticals Provides Corporate Update and Reports Second Quarter 2014 Financial Results 9Arena Pharmaceuticals Provides Corporate Update and Reports Second Quarter 2014 Financial Results 10Arena Pharmaceuticals Provides Corporate Update and Reports Second Quarter 2014 Financial Results 11Sorrento Announces the Unexpected Death of its Chief Business Officer 2Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 2Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 3Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 4Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 5Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 6
... bring a new standard in the field of ... Labs. Made of medical grade silicone, these durable ... a high level of flexibility while maintaining correct ... available in varying stiffnesses. Lengths are determined by ...
... primary objective of the BioPro Toe implant ... will relieve pain and restore motion while ... undisturbed. The procedure used to implant the ... resection. , ,The design for the great ...
Ad-Techs Spinal Electrodes are intended for intraoperative monitoring of Evoked Potentials (EPs) of the descending pathway during spinal surgery. They are offered with 2 or 3 platinum contacts....
... of Ad-Techs products, our Sphenoidal Electrodes are manufactured ... available in stainless steel or platinum and feature ... (70 mm) long, 21 gauge (0.83 mm) introducing ... as kits or sets. You can also choose ...
Medicine Products: