Navigation Links
Stem cells with potential to regenerate injured liver tissue identified by Penn researchers
Date:11/12/2008

PHILADELPHIA - A novel protein marker has been found that identifies rare adult liver stem cells, whose ability to regenerate injured liver tissue has the potential for cell-replacement therapy. For the first time, researchers at the University of Pennsylvania School of Medicine led by Linda Greenbaum, MD, Assistant Professor of Medicine in the Division of Gastroenterology, have demonstrated that cells expressing the marker can differentiate into both liver cells and cells that line the bile duct.

In the future, this marker will allow for the isolation and expansion of these stem cells, which could then be used to help patients whose livers can no longer repair their own tissue. About 17,000 Americans are currently on a waiting list for a liver transplant, according to the American Liver Foundation. The findings appear online this month in the journal Hepatology.

"In a healthy liver, proliferation of mature liver and bile-duct lining cells is sufficient to maintain the necessary size and function of the organ," explains Greenbaum. "This even works when the liver is confronted with mild and acute injury, but the situation changes when injury to the liver is chronic and severe."

For chronic injury, the liver uses a back-up system that stimulates stem cells to proliferate and eventually differentiate into new liver cells. Greenbaum and colleagues found that these dual-potential stem cells can be identified and potentially isolated from other liver cells because they uniquely express the protein Foxl1. The team showed that in two mice models of liver injury, stem cells and their descendents were marked by the expression of FoxL1. The researchers propose to use this marker to isolate the Foxl1-bearing stem cells and transplant them back into damaged livers to restore function.

"At this point, we haven't identified the molecular targets that are regulated by Foxl1 in the liver stem cell," says Greenbaum. The researchers also do not yet know what signals activate the expression of Fox l1 and how exactly it is related to liver function. But, they finally have a molecular handle on identifying liver stem cells, which have remained elusive to scientists.

"This work has significant implications for cell-replacement therapies of chronic liver disease in the future," says Greenbaum.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Related medicine news :

1. Protein can nurture or devastate brain cells, depending on its friends, researchers find
2. Researchers find stem cells from monkey teeth can stimulate growth and generation of brain cells
3. Heart Valves Fashioned From Stem Cells in Umbilical Cord Blood
4. USC researchers identify key mechanism that regulates the development of stem cells into neurons
5. Researchers aim to over-stress already taxed mantle cell lymphoma cells
6. New advancements in the use of adult, embryonic stem cells for tissue regeneration
7. Therapy may block expansion of breast cancer cells
8. BioLife Solutions to Supply CryoStor(TM) to Cryobanks International as Standard Media for Preservation and Storage of Umbilical Cord Blood Stem Cells
9. Penn scientists show how body determines optimal amount of germ-fighting B cells
10. Parasites that live inside cells use loophole to thwart immune system
11. Persistent bacterial infection exploits killing machinery of immune cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stem cells with potential to regenerate injured liver tissue identified by Penn researchers
(Date:2/12/2016)... , ... February 12, 2016 , ... With the exception of restorative dentistry, to date ... decay. With the recent approval by the FDA, there is a now a new ... fluoride varnish, SDF is very simple and quick to apply. The application is as ...
(Date:2/11/2016)... ... February 12, 2016 , ... Fitbody Personal Training offers outdoor training classes which ... to get fit and healthy. Located in Phoenixville, PA, the classes are structured as ... for horseback riders who want to lose weight and tone up. This class offers ...
(Date:2/11/2016)... ... February 11, 2016 , ... According to an article ... as a weight loss dietary supplement, is being recalled due to the discovery that ... because there is not a single supplement on the market proven to help people ...
(Date:2/11/2016)... ... February 11, 2016 , ... Student-doctors from Western University ... Match Program Tuesday, February 9, taking one of the final steps in their ... education positions across the country. Of the 103 student-doctors who comprise the College ...
(Date:2/11/2016)... ... February 11, 2016 , ... Dr. Sadati’s recent ... cosmetic procedures. Along with performing procedures, the magazine also highlights that Dr. Sadati ... procedures. One of the most common procedures he performs is his natural facelift. ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... Feb. 11, 2016 Stem cells are primitive ... by self-renewal and the capacity to differentiate into mature ... discovery, as the first mouse embryonic stem cells were ... until 1995 that the first culturing of embryonic stem ... were not produced until 2006 As a result of ...
(Date:2/11/2016)... , Feb. 11, 2016  Governor Andrew M. ... will create 1,400 jobs throughout Western New ... partnership with the SUNY Polytechnic Institute, includes a major ... Building in Buffalo , as well ... manufacturing facility in Dunkirk . The ...
(Date:2/11/2016)... , Feb. 11, 2016 AAIPharma ... provider of custom manufacturing and development services for ... sterile fill-finish capabilities and capacity in its ... in demand has driven several recent investments. ... it had one filling line with small-scale lyophilization. ...
Breaking Medicine Technology: