Navigation Links
Stem cells with potential to regenerate injured liver tissue identified by Penn researchers
Date:11/12/2008

PHILADELPHIA - A novel protein marker has been found that identifies rare adult liver stem cells, whose ability to regenerate injured liver tissue has the potential for cell-replacement therapy. For the first time, researchers at the University of Pennsylvania School of Medicine led by Linda Greenbaum, MD, Assistant Professor of Medicine in the Division of Gastroenterology, have demonstrated that cells expressing the marker can differentiate into both liver cells and cells that line the bile duct.

In the future, this marker will allow for the isolation and expansion of these stem cells, which could then be used to help patients whose livers can no longer repair their own tissue. About 17,000 Americans are currently on a waiting list for a liver transplant, according to the American Liver Foundation. The findings appear online this month in the journal Hepatology.

"In a healthy liver, proliferation of mature liver and bile-duct lining cells is sufficient to maintain the necessary size and function of the organ," explains Greenbaum. "This even works when the liver is confronted with mild and acute injury, but the situation changes when injury to the liver is chronic and severe."

For chronic injury, the liver uses a back-up system that stimulates stem cells to proliferate and eventually differentiate into new liver cells. Greenbaum and colleagues found that these dual-potential stem cells can be identified and potentially isolated from other liver cells because they uniquely express the protein Foxl1. The team showed that in two mice models of liver injury, stem cells and their descendents were marked by the expression of FoxL1. The researchers propose to use this marker to isolate the Foxl1-bearing stem cells and transplant them back into damaged livers to restore function.

"At this point, we haven't identified the molecular targets that are regulated by Foxl1 in the liver stem cell," says Greenbaum. The researchers also do not yet know what signals activate the expression of Fox l1 and how exactly it is related to liver function. But, they finally have a molecular handle on identifying liver stem cells, which have remained elusive to scientists.

"This work has significant implications for cell-replacement therapies of chronic liver disease in the future," says Greenbaum.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Related medicine news :

1. Protein can nurture or devastate brain cells, depending on its friends, researchers find
2. Researchers find stem cells from monkey teeth can stimulate growth and generation of brain cells
3. Heart Valves Fashioned From Stem Cells in Umbilical Cord Blood
4. USC researchers identify key mechanism that regulates the development of stem cells into neurons
5. Researchers aim to over-stress already taxed mantle cell lymphoma cells
6. New advancements in the use of adult, embryonic stem cells for tissue regeneration
7. Therapy may block expansion of breast cancer cells
8. BioLife Solutions to Supply CryoStor(TM) to Cryobanks International as Standard Media for Preservation and Storage of Umbilical Cord Blood Stem Cells
9. Penn scientists show how body determines optimal amount of germ-fighting B cells
10. Parasites that live inside cells use loophole to thwart immune system
11. Persistent bacterial infection exploits killing machinery of immune cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stem cells with potential to regenerate injured liver tissue identified by Penn researchers
(Date:5/26/2016)... ... May 26, 2016 , ... There are many ways to cook a hot ... suggests that Americans prefer their dogs straight off the grill. Of the 90 percent ... favorite way to cook a hot dog, far outpacing other cooking methods such as ...
(Date:5/26/2016)... ... , ... Connor Sports, through its Connor Cares initiative, will continue ... Catchings Legacy Tour that will commemorate the Indiana Fever legend’s hall-of-fame career and ... forms and levels of the game, Connor Sports has committed to a significantly increased ...
(Date:5/26/2016)... ... ... MadgeTech will be showcasing its line of data logging products , ... MadgeTech headquarters. With products sold in more than 100 countries around the world, MadgeTech ... , In 2012, NASA strategically set up 17 RHTemp101A MadgeTech data loggers around ...
(Date:5/26/2016)... ... May 26, 2016 , ... Memorial Day Weekend marks the ... Insurance is sharing tips to make sure your family and vehicle are ready ... Safety Council, there may be 439 deaths and an additional 50,500 serious injuries from ...
(Date:5/26/2016)... Rafael, CA (PRWEB) , ... May 26, 2016 ... ... will be offering campers a multitude of activities from daily practices, arts & ... self-confidence. , Camp Directors Amber East-D’Anna and Christy Evans have combined backgrounds in ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... May 25, 2016 MedDay, a biotechnology ... that an oral presentation entitled "High doses of biotin in ... will be given by Professor Ayman Tourbah , Principal ... of the European Academy of Neurology (EAN) in ... disorders 3" will take place on Sunday, 29 May 2016 ...
(Date:5/24/2016)... 24, 2016   ... primären Endpunkte und demonstriert Ebenbürtigkeit bei ... ‚ausgezeichneter plus guter , ...      (Logo: http://photos.prnewswire.com/prnh/20130829/633895-a ) ... positive Daten von der MORA-Studie der Phase III ...
(Date:5/24/2016)... May 24, 2016 Celsion Corporation (NASDAQ: ... company, today provided an update on its ongoing ... trial combining GEN-1, the Company,s DNA-based immunotherapy, with ... newly-diagnosed patients with advanced ovarian cancer who will ... GEN-1 is an IL-12 DNA plasmid vector formulated ...
Breaking Medicine Technology: