Navigation Links
Stem cells train heart following heart attack

Following a heart attack, part of the heart tissue dies. It is still not possible to restore the scar tissue arising as a result of this. The majority of stem cell researchers attempt to make new heart muscle cells from stem cells. Liesbeth Winter of the Leiden University Medical Center, however, was able to prove the concept of using the embryonic potential of adult human cells to train the heart: this cell therapy ensured that less tissue died and that the remaining heart cells functioned better.

The PhD student used the 'Epicardium Derived Cell' or EPDC. This cell plays a crucial role during embryonic heart development: the embryonic EPDCs provide cells for the connective tissue skeleton of the heart and for the walls of the coronary arteries. EPDCs also play an important role in the formation of a thick, compact heart muscle wall. Without EPDCs, the heart muscle would remain very thin and the embryo would die.

Human cells stimulate mouse cells

Winter used adult human EPDCs that she extracted from the atrium of the heart. She transplanted these cells to a mouse heart that had suffered an infarction. The mice receiving these cells retained a better heart function than mice without these cells, both in the short term and in the longer term of several weeks. The human cells also ensured that less mouse cells died off. Two weeks following cell transplantation, the treated hearts contained more blood vessels, the heart muscle cells exhibited an increased activity of DNA damage repair, and the wall was thicker where the infarct had occurred. These results suggest that EPDCs have an almost instant stimulating effect on the surrounding heart tissue following transplantation.


Contact: Liesbeth Winter
Netherlands Organization for Scientific Research

Page: 1

Related medicine news :

1. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
2. Brain cells work differently than previously thought
3. Embryonic Stem Cells Repair Human Heart
4. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
5. Circulating fats kill transplanted pancreas cells, study shows
6. Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
7. Melanoma drug revs immune cells but cancer cells ignore it
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Embryonic stem cells used to grow cartilage
10. Molecular probe paints cancer cells in living animals, Stanford researchers find
11. USC researcher identifies stem cells in tendons that regenerate tissue in animal model
Post Your Comments:
(Date:6/24/2016)... ... 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. ... the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has ... , Sickle Cell Disease (SCD) is a disorder of the red blood cells, which ...
(Date:6/24/2016)... ... , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys ... peers for this recognition are considered among the top 2 percent of lawyers practicing ... members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. ...
(Date:6/24/2016)... ... ... of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum Wage’ ... 2020 and then adjusting it yearly to increase at the same rate as the median ... floor does not erode again, and make future increases more predictable. , The company is ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty Network, ... M. Weintraub as a prominent plastic surgeon and the network’s newest partner. ... the most handsome men, look naturally attractive. Plastic surgery should be invisible.” He ...
(Date:6/24/2016)... ... 24, 2016 , ... National recruitment firm Slone Partners is pleased ... and genomics experience, as Vice President of North American Capital Sales at HTG ... leading the sales team in the commercialization of the HTG EdgeSeq system and associated ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- The Academy of Managed Care Pharmacy (AMCP) today ... allow biopharmaceutical companies to more easily share health care ... coverage decisions, a move that addresses the growing need ... The recommendations address restrictions in the sharing of product ... a prohibition that hinders decision makers from accessing HCEI ...
(Date:6/24/2016)... Research and Markets has announced the addition of the ... to their offering. ... World Market for Companion Diagnostics covers the world market for ... report includes the following: , World IVD ... (N. America, EU, ROW), 2015-2020 , World IVD Companion ...
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
Breaking Medicine Technology: