Navigation Links
Stem cells show promise for treating infertility in cancer patients
Date:11/1/2012

AUDIO: This is an audio clip of Deborah Sweet of Cell Stem Cell interviewing Dr. Kyle Orwig of the University of Pittsburgh School of Medicine regarding his recent preclinical study "Spermatogonial...

Click here for more information.

A promising stem-cell-based approach for treating infertility has been successfully demonstrated in non-human primates, as reported in a study published by Cell Press in the November issue of the journal Cell Stem Cell. The preclinical study represents an important milestone for translating this strategy to the clinic, particularly for cancer survivors who have been rendered infertile by chemotherapy they received before reaching sexual maturity.

"This is the first study to demonstrate that transplanted spermatogonial stem cells can produce functional sperm in higher primates," says senior study author Kyle Orwig of the University of Pittsburgh and Magee-Womens Research Institute. "This is an important step toward human translation."

Cancer patients who undergo radiation therapy or chemotherapy often become infertile because these treatments damage dividing cells, including not only cancer cells but also spermatogonial stem cells (SSCs)stem cells that develop into sperm. Prior to cancer therapy, adult men can cryopreserve their sperm and later use these cells to father children. But prepubertal boys don't have this option because they have not yet produced any mature sperm, so cancer treatments can leave them permanently infertile.

One promising strategy for these young patients is to preserve their SSCs before they undergo cancer therapy and later transplant these cells after they finish cancer treatment and reach sexual maturity. This approach has worked in a range of animal models, but past studies in large animals have primarily used radiation therapy to cause infertility, even though chemotherapy is also a common source of infertility in cancer patients.

In the new study, Orwig and his team cryopreserved SSCs from monkeys before treating them with a commonly used chemotherapy drug. After treatment, they injected the SSCs into the testes of these animals and found that the cells produced sperm in the majority of transplant recipients. Moreover, the SSC-derived sperm of one animal was capable of fertilizing egg cells and producing embryos that developed normally.

As noted in the accompanying In Translation article by Pierre Fouchet and colleagues, this work "constitutes a milestone in the field of reproduction, and generates hope for restoring fertility in survivors of childhood cancer."


'/>"/>

Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Related medicine news :

1. A protein’s role in helping cells repair DNA damage
2. Scientists create endless supply of myelin-forming cells
3. Stem Cells to Cartilage? Promising Results Seen in Mice
4. Scientists decode software instructions of aggressive leukemia cells
5. New options for ease and accuracy in extraction of rare cells or separating blood
6. Stimulating brain cells with light
7. Research identifies protein that regulates key fate decision in cortical progenitor cells
8. UGA researchers boost efficacy of drugs by using nanoparticles to target powerhouse of cells
9. At the right place at the right time -- new insights into muscle stem cells
10. Lack of oxygen in cancer cells leads to growth and metastasis
11. Human Stem Cells Restore Hearing to Deaf Gerbils in Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... First ... United States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell ... facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
(Date:6/25/2016)... ... , ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter ... bar too high can result in disappointment, perhaps even self-loathing. However, those who set ... , Research from PsychTests.com reveals that behind the tendency to set low ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set of ... or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, Serenity ... event. , Trauma sufferers tend to feel a range of emotions, from depression, guilt, ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- In a startling report released today, National Safety Council ... comprehensive, proven plan to eliminate prescription opioid overdoses. Prescription ... are tackling the worst drug crisis in recorded U.S. history, assigned ... Kentucky , New Mexico , ... 28 failing states, three – Michigan , ...
(Date:6/23/2016)... Research and Markets has announced the addition of the ... to 2022" report to their offering. ... financial data derived from varied research sources to present unique ... on the market during the next five years, including a ... markets, regional and country level analysis. The report provides a ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Key Pharma News Issue 52" report to their offering. ... need in influenza treatment creates a favourable commercial environment for ... and growing patient base that will serve to drive considerable ... flu vaccine would serve to cap sales considerably, but development ...
Breaking Medicine Technology: