Navigation Links
Stem cells make bone marrow cancer resistant to treatment
Date:1/11/2008

lls act as cancer stem cells.

The Johns Hopkins scientists also compared the response of these special stem cells with the bulk of multiple myeloma plasma cells, to four different chemotherapy medications commonly used to treat patients with the disease: dexamethasone, lenadilomide, bortezomib and 4-hydroxycyclophosphamide. While all four agents significantly inhibited the growth of the plasma cells, none inhibited the stem cells.

To their surprise, the research team noted that the multiple myeloma stem cells resemble other types of adult stem cells and exhibit similar properties that may make them resistant to chemotherapy. They found that the stem cells contain high levels of enzymes that neutralize toxins, like cancer drugs, and expel them through miniature pumps on their cell surface. The investigators believe that these drug-fighting enzymes and pumps - also plentiful in normal stem cells - may help cancer stem cells resist treatment.

Nature made normal stem cells very hearty for a reason, namely to survive and help repair damaged tissues and organs after injury or illness, says William Matsui, M.D., an assistant professor of oncology at Hopkins and the studys lead investigator. To us, it makes sense that the same processes that protect normal stem cells also exist in cancer stem cells to make them resistant to chemotherapy. We need to develop new ways to target the specific biology of cancer stem cells to prevent the continued production of mature tumor cells and disease relapse.

Standard cancer therapy is like mowing the weed - it gets rid of the disease transiently but the dandelion always grows back. We need to get rid of the root to cure disease, and therefore need a different type of therapy - mowing wont work, says Jones.

Matsui says the work also may make it possible to track the rare myeloma stem cells as a marker of how well a patient is doing during treatment.

Multiple myeloma is the second
'/>"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Jefferson scientists find protein helps pancreatic cancer cells evade immune system and spread
2. New insight into factors that drive muscle-building stem cells
3. Forever young: Differentiation blocked in tumor stem cells
4. Some Immature Brain Cells May Promote Tumors
5. Localized Breast Cancer Cells Have Potential to Spread
6. FOXO factor promotes survival of oxygen-deprived cancer cells
7. Cancer stem cells: know thine enemy
8. Microchip Spots Stray Tumor Cells in the Bloodstream
9. Brain Cells More Powerful Than You Think
10. Microchip-based device can detect rare tumor cells in bloodstream
11. St. Jude finds link between cellular defense processes, showing how cancer cells survive
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... July 28, 2014 Shofner Vision ... Military June . Renowned LASIK and Cataract Surgeon, ... provide significant funds and public awareness for local ... military personnel and their families. “This was our ... give nearly $5,000 to a variety of local ...
(Date:7/28/2014)... more chronic medical conditions people have at retirement age, ... study claims. Since nearly four in five ... Hopkins Bloomberg School of Public Health in Baltimore said ... expectancy are slowing in the United States. "Living ... and heart failure is now the norm and not ...
(Date:7/28/2014)... DC (PRWEB) July 28, 2014 SIMpalm ... app for iOS, App is available on iTunes for ... of its kind, Audio Chef allows you to listen and ... cuisine the easy way: simply get out the ingredients and ... need to measure or prepare ingredients ahead of time, just ...
(Date:7/28/2014)... Lake City, Utah (PRWEB) July 28, 2014 ... protein powders and drinks, announced that it will be ... drink line of products this summer. The additional flavors ... with clean pure taste-free protein , Inspire Pomegranate Razz ... Vanilla - flavor of soft-serve vanilla cone , Bariatric ...
(Date:7/28/2014)... Camden, NJ (PRWEB) July 28, 2014 ... to provide enhanced access and reduced wait times for ... only six hospital systems in the state—and the only ... HealthNet Federal Services Patient-Centered Community Care program (PC3). PC3 ... Veterans Administration (VA) hospital cannot provide services due to ...
Breaking Medicine News(10 mins):Health News:Shofner Vision Center’s “Operation Military June” Provided Funds For Local Not-For-Profit Organizations Supporting Military And Their Families 2Health News:Shofner Vision Center’s “Operation Military June” Provided Funds For Local Not-For-Profit Organizations Supporting Military And Their Families 3Health News:Chronic Medical Conditions Can Shorten Seniors' Lives: Study 2Health News:Audio Chef Co. Releases Audio Cooking App for iPhone/iPad/iPod touch 2Health News:Audio Chef Co. Releases Audio Cooking App for iPhone/iPad/iPod touch 3Health News:Audio Chef Co. Releases Audio Cooking App for iPhone/iPad/iPod touch 4Health News:Bariatric Eating Announces Three New Protein Shake Flavors 2Health News:Lourdes Expands Military Partnership with Veterans 2Health News:Lourdes Expands Military Partnership with Veterans 3
... can be made from some of the same parts ... developed a way to measure the growth and drug ... a microscope. The new biosensor promises to speed ... the Richard Smalley Distinguished University Professor of Chemistry, Physics ...
... Thea Friedman, M.D., associate scientist and director of oncology ... Hackensack University Medical Center was recently awarded a National ... research grant to improve allogeneic blood and marrow transplantation ... million in funding over the next five years. ...
... Boston, Mass. Following a successful Phase 1 study ... Massachusetts Medical School (UMMS) today announced the beginning of ... a human monoclonal antibody they developed to prevent ... in transplant patients. The first patients were enrolled ...
... 18 January 2011 - A recent study by Merikangas ... the Journal of the American Academy of Child ... of adolescents that are affected with severely impairing mental ... The researchers found that approximately one third of adolescents ...
... have used a type of brain scanning, known as functional ... blood flow in the brain and to correlate this with ... which could improve is reported in the International Journal ... known since the 1890s that changes in blood flow and ...
... for breast cancer are well studied and documented. Thus, scientists ... onset of menopause and a family history of breast cancer ... neither an individual woman nor medicine can influence whether family ... - these are risk factors on which we have no ...
Cached Medicine News:Health News:See how they grow: Monitoring single bacteria without a microscope 2Health News:See how they grow: Monitoring single bacteria without a microscope 3Health News:Oncology basic research director at John Theurer Cancer Center continues transplantation research 2Health News:First liver transplant patients receive experimental drug to prevent hepatitis C infection 2Health News:First liver transplant patients receive experimental drug to prevent hepatitis C infection 3Health News:Adolescents with severe mental disorders have never received treatment 2Health News:Functional boost for magnetic resonance imaging 2Health News:Scientists identify avoidable breast cancer risk factors 2
(Date:7/28/2014)... VALLEY, Pa. , July 28, 2014  Air ... reliable, uninterrupted supply of medical oxygen is vital to ... to technical innovations that not only improve the efficiency ... use. Air Products will highlight these systems—including systems for ... that reduce oxygen loss—from August 4-5 at the ...
(Date:7/28/2014)... , July 28, 2014 Southern Research ... , Ph.D., President and CEO of Southern Research ... Release Society (CRS) for the 2014-2015 term.  The ... on July 12 in Chicago ... The Controlled Release Society is ...
(Date:7/28/2014)... , July 28, 2014  A prospective study ... Sweden has validated the performance of ... and has associated volumetrically assessed breast density measurements ... Epidemiology, Biomarkers & Prevention (DOI: 10.1158/1055-9965.EPI-13-1219), the ... tool for widespread breast cancer risk assessment," was ...
Breaking Medicine Technology:Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 2Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 3Arthur J. Tipton, Ph.D., Named President of Controlled Release Society 2Arthur J. Tipton, Ph.D., Named President of Controlled Release Society 3Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 2Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 3Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 4
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: