Navigation Links
Stem cells make bone marrow cancer resistant to treatment
Date:1/11/2008

Scientists at the Johns Hopkins Kimmel Cancer Center say they have evidence that cancer stem cells for multiple myeloma share many properties with normal stem cells and have multiple ways of resisting chemotherapy and other treatments.

A report on the evidence, published in the Jan. 1 issue of the journal Cancer Research, may explain why the disease is so persistent, the Johns Hopkins scientists say, and pave the way for treatments that overcome the cells drug resistance. Multiple myeloma affects bone marrow and bone tissue.

Cancer stem cells that have distinct biology and drug sensitivity as compared with the bulk of a cancer may explain why multiple myeloma, like many other cancers, so often relapses even after chemotherapy puts patients into remission, says Richard J. Jones, M.D., professor and director of bone marrow transplant at Hopkins Kimmel Cancer Center and one of the scientists who authored the new report.

The existence of cancer stem cells - a topic of some controversy in cancer biology - is seen by some scientists as a useful explanation for the long history of difficulty in overcoming some cancers persistence.

The Hopkins investigators previously had uncovered a rare stem cell in myeloma, accounting for less than one percent of all the cancers cells. Working with cell samples from myeloma patients, the team found that this stem cell originates from immune system B-cells and is capable of giving rise to the malignant bone marrow cells characteristic of the disease.

In the current study, the scientists isolated stem cells from the blood of four patients with multiple myeloma and transplanted them into mice. All of the animals developed hind-limb paralysis and showed signs of cancer in the bone marrow. By contrast, plasma cells that were transplanted from multiple myeloma patients to mice did not engraft. The Hopkins scientists say that recreating the disease in mice provides more evidence that these ce
'/>"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Jefferson scientists find protein helps pancreatic cancer cells evade immune system and spread
2. New insight into factors that drive muscle-building stem cells
3. Forever young: Differentiation blocked in tumor stem cells
4. Some Immature Brain Cells May Promote Tumors
5. Localized Breast Cancer Cells Have Potential to Spread
6. FOXO factor promotes survival of oxygen-deprived cancer cells
7. Cancer stem cells: know thine enemy
8. Microchip Spots Stray Tumor Cells in the Bloodstream
9. Brain Cells More Powerful Than You Think
10. Microchip-based device can detect rare tumor cells in bloodstream
11. St. Jude finds link between cellular defense processes, showing how cancer cells survive
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2013)... May 19, 2013 6Webs.com is the ... companies. Homeowners who are considering an alarm system can ... the nation's leading security system providers online at 6Webs.com. ... best DIY home security system companies, 6Webs.com ... reviews dozens of home security companies before ranking the ...
(Date:5/19/2013)... 2013 The Pradaxa lawyers at Bernstein ... recently convened for hundreds of Pradaxa bleeding ... in U.S. District Court, Southern District of Illinois. ... May 14th, the Conference addressed the status of depositions ... the Conference that Defendants submitted a list of early ...
(Date:5/19/2013)... The Fat Loss Code program developed by Shawn ... help people get in shape, and gain a healthy life ... also is a natural fat loss system that provides people ... this fat loss diet program claimed that The Fat Loss ... keep body fat off long-term. After Shawn Stevenson launched this ...
(Date:5/19/2013)... Exciting new Skin Brushes are available ... great practice known through the ages but is a ... body brushing, has so many benefits for our health ... "We love that circulation and lymphatic systems get a ... skin, is supported through Skin Brushing." , Why is ...
(Date:5/19/2013)... 2013 The AMTC team will be screening ... Georgia Convention & Trade Center on June 1st. Professionals and ... auditions are free of charge. , Actors, Models and Talent ... of successful artists and grads like Caitlin Kinney - SYTYCD, ... , Chris Young - on his Liquid Neon 2013 Tour, ...
Breaking Medicine News(10 mins):Health News:Top Rated DIY Home Security System Companies Published by 6Webs.com 2Health News:Pradaxa Lawyers at Bernstein Liebhard LLP Report on Recent Status Conference in Federal Pradaxa Litigation 2Health News:Pradaxa Lawyers at Bernstein Liebhard LLP Report on Recent Status Conference in Federal Pradaxa Litigation 3Health News:Weight Loss Secrets | How “The Fat Loss Code” Helps People Gain A Healthy Life And Get In Shape - Health Review 2Health News:Exciting New Skin Brushes at Sublime Beauty® Bring Health and Beauty Benefits; Celebrities and Models Know the Secret 2Health News:Actors, Models and Talent for Christ Hosting Auditions in Columbus, GA June 1st in Search of Local Talent 2
... ... and scars which could help up to 23 million women , ... (PRWEB) May 30, 2010 -- The Harley Medical Group has announced that ... market, which promises to reduce the appearance of stretch marks, medically termed striae, and scars by ...
... ... Raising chickens in the backyard is growing more popular as Americans ... backyard chickens increases, so does the need to educate owners about keeping ... Plant Health Inspection Service’s (USDA/APHIS) Biosecurity for Birds campaign is renewing its ...
... ... compliance wherever PCs are located , ... (PRWEB) June 2, 2010 -- Beachhead Solutions Inc. announced today the ... Managed Service Providers (MSPs). For those organizations affected by the new laws requiring encryption ...
... As part of a national clinical trial, UT Southwestern ... two popular treatments for one of the most common ... incontinence affects up to 50 percent of women in ... with stress incontinence experience leakage during increases in abdominal ...
... one-size-fits-all medicine will eventually be history; after all it is ... same for everyone. For patients with nonsmall cell lung ... people annually, the treatment currently available is basically the same ... respond to treatment while others may not. New biological markers ...
... effects linked to taking too much supplemental calcium are ... an upcoming issue of the Journal of the ... so-called milk-alkali or calcium-alkali syndrome is growing in large ... vitamin D supplements. The milk-alkali syndrome arose in ...
Cached Medicine News:Health News:The Harley Medical group launches exclusive treatment for stretch marks and scars 2Health News:The Harley Medical group launches exclusive treatment for stretch marks and scars 3Health News:Backyard Poultry A Growing Trend Throughout US - USDA Offers Pointers on Keeping them Safe, 2Health News:Backyard Poultry A Growing Trend Throughout US - USDA Offers Pointers on Keeping them Safe, 3Health News:PC Encryption Compliance Delivered Through The Cloud Now Available As Simple Monthly Service For Business 2Health News:PC Encryption Compliance Delivered Through The Cloud Now Available As Simple Monthly Service For Business 3Health News:UT Southwestern investigators perform head-to-head comparison of incontinence treatments 2Health News:A prognostic and predictive biomarker for nonsmall cell lung cancer 2Health News:Calcium supplements: too much of a good thing? 2
(Date:5/17/2013)...  Sony Biotechnology Inc. ("Sony") today announced the launch of ... sorting chip.  Sony will also be exhibiting its newly rebranded ... Sorter, the EC800 flow cytometer, and new SP6800 Spectral Analyzer ... will be held at the San Diego ... , from May 20 - 22.  The ...
(Date:5/17/2013)... , May 17, 2013  TechAtlas Group has ... their competitive landscape map for the Chronic Kidney ... 90 international companies with drugs and devices currently ... and its sequelae. (Logo:  ... , hypertension - renal denervation , ...
(Date:5/17/2013)... 2013 Fuse Science, Inc. (OTCQB: DROP), ( www.fusescience.com ... developing new, patent-pending technologies poised to redefine how consumers receive ... hold a business update teleconference and webcast for shareholders and ... at 4:30 PM ET. Fuse Science, Inc. ... call and will be joined by Rubin Hanan ...
Breaking Medicine Technology:Sony Delivers New Technology for Science to CYTO 2013 2TechAtlas Group Releases Innovative Chronic Kidney Disease Landscape Map 2Fuse Science, Inc. to Hold Business Update Webcast and Teleconference on May 22nd 2
... Chance, as international counsel, has advised Pfizer on the conditional ... The clearance was issued by the Ministry of Commerce (MOFCOM) ... authorities was one of the key conditions of the Pfizer/Wyeth ... deal; decisions are awaited from the Australian, Canadian and US ...
... EMD Serono, Inc. an affiliate of Merck ... New Drug Application (NDA) to the US Food and ... investigational oral formulation of cladribine, as a therapy for ... sclerosis (MS). Cladribine Tablets has the potential to be ...
Cached Medicine Technology:Clifford Chance Advises Pfizer on Conditional Clearance in China of Its Merger with Wyeth 2EMD Serono Submits Application for Cladribine Tablets as a Potential Oral Short-Course Multiple Sclerosis Therapy in the United States 2EMD Serono Submits Application for Cladribine Tablets as a Potential Oral Short-Course Multiple Sclerosis Therapy in the United States 3EMD Serono Submits Application for Cladribine Tablets as a Potential Oral Short-Course Multiple Sclerosis Therapy in the United States 4
... GORE SEAMGUARD® Staple Line Reinforcement ... in reducing postoperative pulmonary air leaks ... hospital care. This inert, biocompatible, ePTFE ... non-biological.,It is easy to load and ...
... for the repair of abdominal hernias. It ... two distinct sides. One side of ... of sodium hyaluronate and carboxymethylcellulose (similar to ... side is bioresorbable, providing a temporary physical ...
... Company, we recognize that there are circumstances ... in-growth between the prosthesis and the repair ... all the products in Bards complete line ... proven, versatile repair.,The Reconix Patch is Bards ...
... PLUS Biomaterial is the first hernia ... controlling potential operative contamination of the ... two antimicrobial preservative agents, silver carbonate ... inhibit bacterial colonization on the patch ...
Medicine Products: