Navigation Links
Stem cells linked to cognitive gain after brain injury in preclinical study
Date:11/4/2013

HOUSTON (Nov. 4, 2013) A stem cell therapy previously shown to reduce inflammation in the critical time window after traumatic brain injury also promotes lasting cognitive improvement, according to preclinical research led by Charles Cox, M.D., at The University of Texas Health Science Center at Houston (UTHealth) Medical School.

The research was published in today's issue of STEM CELLS Translational Medicine.

Cellular damage in the brain after traumatic injury can cause severe, ongoing neurological impairment and inflammation. Few pharmaceutical options exist to treat the problem. About half of patients with severe head injuries need surgery to remove or repair ruptured blood vessels or bruised brain tissue.

A stem cell treatment known as multipotent adult progenitor cell (MAPC) therapy has been found to reduce inflammation in mice immediately after traumatic brain injury, but no one had been able to gauge its usefulness over time.

The research team led by Cox, the Children's Fund, Inc. Distinguished Professor of Pediatric Surgery at the UTHealth Medical School, injected two groups of brain-injured mice with MAPCs two hours after the mice were injured and again 24 hours later. One group received a dose of 2 million cells per kilogram and the other a dose five times stronger.

After four months, the mice receiving the stronger dose not only continued to have less inflammationthey also made significant gains in cognitive function. A laboratory examination of the rodents' brains confirmed that those receiving the higher dose of MAPCs had better brain function than those receiving the lower dose.

"Based on our data, we saw improved spatial learning, improved motor deficits and fewer active antibodies in the mice that were given the stronger concentration of MAPCs," Cox said.

The study indicates that intravenous injection of MAPCs may in the future become a viable treatment for people with traumatic brain injury, he said.

Cox, who directs the Pediatric Surgical Translational Laboratories and Pediatric Program in Regenerative Medicine at UTHealth, is a leader in the field of autologous and blood cord stem cells for traumatic brain injury in children and adults. Results from a Phase I study were published in a March 2011 issue of Neurosurgery, the journal of the Congress of Neurological Surgeons. Cox also directs the Pediatric Trauma Program at Children's Memorial Hermann Hospital.


'/>"/>

Contact: Deborah Lake
deborah.m.lake@uth.tmc.edu
713-500-3304
University of Texas Health Science Center at Houston
Source:Eurekalert  

Related medicine news :

1. UC develops unique nano carrier to target drug delivery to cancer cells
2. Cell nucleus protein in brown fat cells governs daily control of body temperature
3. SmartCells Fall Protection Products Featured at LeadingAge -- Idea House, Interface, Best Bath
4. Study of sister stem cells uncovers new cancer clue
5. Johns Hopkins researchers erase human brain tumor cells in mice
6. Targeting memory T-cells in Type 1 diabetes
7. Diet Doc Weight Loss Plans Announces New Enteric-Coated 700 mg Pure Fish Oil Capsules, Shown to Strengthen Brain Cells
8. Direct Methanol Fuel Cells (DMFC) Unit Shipments to Grow at CAGR of 45.3% from 2011 to 2016 - New Report by MarketsandMarkets
9. Mount Sinai Researchers Show Stem Cells Are Wired for Cooperation, Down to the DNA
10. Study Indicates Benefits of Stem Cells in Treating MS Declines With Donor’s Age
11. Inflammatory protein converts glioblastoma cells into most aggressive version
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stem cells linked to cognitive gain after brain injury in preclinical study
(Date:2/18/2017)... ... February 17, 2017 , ... CONTACT:, Glenn Vallecillos, MD, FACS, ... surgeon Dr. Glenn Vallecillos experiments SculpSure, the hot, new, aesthetic, non-surgical ... has been centered around that idea that to achieve ones desired results a ...
(Date:2/17/2017)... ... February 17, 2017 , ... ... pace. Enovate Medical has introduced an innovative workstation designed to reduce nursing fatigue ... the Encore Mobile EHR Workstation offers a lightweight, highly mobile, multi-functional alternative to ...
(Date:2/17/2017)... , ... February 17, 2017 , ... ... Dr. Carol Francis' goals for each and every seminar, session and ... Francis will demonstrate five different brainwave tools which help energize creativity, focus mental ...
(Date:2/17/2017)... ... February 17, 2017 , ... ... services, announced today that Karen Pilley has been promoted to Chief Executive Officer. ... today’s shifting healthcare paradigm – a shift that demands the transition from pay-for-service ...
(Date:2/17/2017)... ... February 17, 2017 , ... Top neuroendocrine cancer doctors, nurses and ... Summit from February 21 - 23 in Beaver Creek, CO. It was announced today ... Summit’s second year in Beaver Creek, hosting over 60 faculty members and addressing unmet ...
Breaking Medicine News(10 mins):
(Date:2/16/2017)... -- Absorption Systems, a global leader in nonclinical testing ... announce that its Chief Operating Officer, Sid Bhoopathy ... the 2017 Executive Management Award. The award is sponsored ... for their creative management vision, leadership philosophy, innovative strategy ... is on March 8, 2017 at the Ballroom at ...
(Date:2/16/2017)... N.J. , Feb. 16, 2017 Quest ... provider of diagnostic information services, today announced that it ... Companies" for 2017 by Fortune. The ... six companies in the "Health Care: Pharmacy and Other ... only diagnostic information services company to attain the designation. ...
(Date:2/16/2017)... , Feb. 16, 2017 The global ... USD 7.88 billion by 2021 from USD 5.49 billion ... On the basis of type, the preparative and ... preparative chromatography. In 2016, the process chromatography segment is ... global preparative and process chromatography. Growth in this segment ...
Breaking Medicine Technology: