Navigation Links
Stem cells linked to cognitive gain after brain injury in preclinical study
Date:11/4/2013

HOUSTON (Nov. 4, 2013) A stem cell therapy previously shown to reduce inflammation in the critical time window after traumatic brain injury also promotes lasting cognitive improvement, according to preclinical research led by Charles Cox, M.D., at The University of Texas Health Science Center at Houston (UTHealth) Medical School.

The research was published in today's issue of STEM CELLS Translational Medicine.

Cellular damage in the brain after traumatic injury can cause severe, ongoing neurological impairment and inflammation. Few pharmaceutical options exist to treat the problem. About half of patients with severe head injuries need surgery to remove or repair ruptured blood vessels or bruised brain tissue.

A stem cell treatment known as multipotent adult progenitor cell (MAPC) therapy has been found to reduce inflammation in mice immediately after traumatic brain injury, but no one had been able to gauge its usefulness over time.

The research team led by Cox, the Children's Fund, Inc. Distinguished Professor of Pediatric Surgery at the UTHealth Medical School, injected two groups of brain-injured mice with MAPCs two hours after the mice were injured and again 24 hours later. One group received a dose of 2 million cells per kilogram and the other a dose five times stronger.

After four months, the mice receiving the stronger dose not only continued to have less inflammationthey also made significant gains in cognitive function. A laboratory examination of the rodents' brains confirmed that those receiving the higher dose of MAPCs had better brain function than those receiving the lower dose.

"Based on our data, we saw improved spatial learning, improved motor deficits and fewer active antibodies in the mice that were given the stronger concentration of MAPCs," Cox said.

The study indicates that intravenous injection of MAPCs may in the future become a viable treatment for people with traumatic brain injury, he said.

Cox, who directs the Pediatric Surgical Translational Laboratories and Pediatric Program in Regenerative Medicine at UTHealth, is a leader in the field of autologous and blood cord stem cells for traumatic brain injury in children and adults. Results from a Phase I study were published in a March 2011 issue of Neurosurgery, the journal of the Congress of Neurological Surgeons. Cox also directs the Pediatric Trauma Program at Children's Memorial Hermann Hospital.


'/>"/>

Contact: Deborah Lake
deborah.m.lake@uth.tmc.edu
713-500-3304
University of Texas Health Science Center at Houston
Source:Eurekalert  

Related medicine news :

1. UC develops unique nano carrier to target drug delivery to cancer cells
2. Cell nucleus protein in brown fat cells governs daily control of body temperature
3. SmartCells Fall Protection Products Featured at LeadingAge -- Idea House, Interface, Best Bath
4. Study of sister stem cells uncovers new cancer clue
5. Johns Hopkins researchers erase human brain tumor cells in mice
6. Targeting memory T-cells in Type 1 diabetes
7. Diet Doc Weight Loss Plans Announces New Enteric-Coated 700 mg Pure Fish Oil Capsules, Shown to Strengthen Brain Cells
8. Direct Methanol Fuel Cells (DMFC) Unit Shipments to Grow at CAGR of 45.3% from 2011 to 2016 - New Report by MarketsandMarkets
9. Mount Sinai Researchers Show Stem Cells Are Wired for Cooperation, Down to the DNA
10. Study Indicates Benefits of Stem Cells in Treating MS Declines With Donor’s Age
11. Inflammatory protein converts glioblastoma cells into most aggressive version
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stem cells linked to cognitive gain after brain injury in preclinical study
(Date:5/6/2016)... ... May 06, 2016 , ... The International Yoga Teacher Training schoo ... the island close to the town famous for its sunsets, Oia. This all inclusive ... continue to have an amazing experience in Greece, we just can’t stay away” says ...
(Date:5/6/2016)... ... May 06, 2016 , ... In honor ... education and corporate training, and the National Military Family Association, a nonprofit that ... as the second full-tuition scholarship recipient of 2016. , “Being awarded this ...
(Date:5/5/2016)... Viejo, CA (PRWEB) , ... May 05, 2016 , ... ... in Final Cut Pro X. Drag and drop a TransWipe preset between two video ... Choose from smooth corner wipes to colored panels with customizable color and orientation options. ...
(Date:5/5/2016)... ... May 05, 2016 , ... The U.S. Food ... requiring e-cigarette manufacturers to submit their products through an arduous federal approval process. ... products that entered the market since February 15, 2007. That would essentially ban ...
(Date:5/5/2016)... FRANCISCO (PRWEB) , ... May 05, 2016 , ... ... the Unites States to promise successful results with IVF and with egg freezing, ... to deliver the most patient-centric and highest quality fertility care, Spring Fertility offers ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... -- Research and Markets has announced the addition ... USA"  report to their offering.  ,     (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ... Positron Emission Tomography (PET) scanner and cyclotron install base ... with the current known number of PET scanners and ... report also contains a detailed breakdown of this equipment ...
(Date:5/5/2016)... DUBLIN , May 5, 2016 ... Markets has announced the addition of the  ... Highlights - 2016"  report to their ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,The latest ... Landscape Highlights - 2016, provides comprehensive ...
(Date:5/4/2016)... 2016  Compass Diversified Holdings (NYSE: CODI ... of leading middle market businesses, announced today its consolidated ... 2016. First Quarter 2016 Highlights , ... or "Cash Flow") of $13.6 million for the first ... $15.0 million for the first quarter of 2016; ...
Breaking Medicine Technology: