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Stem cells in adult testes provide alternative to embryonic stem cells for organ regeneration
Date:9/19/2007

Douglas Scherr -- it is expected that routine retrieval of adult human testicular tissue could be performed safely and in a timely fashion.

Would such an approach work in the female ovary, which also contains a large population of germ cells" The Weill Cornell team says similar techniques might work there as well, although at this point it's just a theory.

"Our achievement using these testes-derived cells has taken us over a decade of painstaking investigation to achieve," says Dr. Rafii. "It points to the potential of this remarkable, but -- until now -- poorly accessed and understood stem cell."

"We hope this seminal paper will set the stage for designing clinical strategies for regenerating failing organs in patients with heart disease, Alzheimer's, Parkinson's, stroke, diabetes, arthritis, macular degeneration and infertility induced by chemotherapy and irradiation," Dr. Rafii adds. "Delivering stem cells derived from MASCs, loaded with toxic factors, to the tumor microenvironment may also provide a novel strategy to target tumor blood vessels and inhibit cancer growth and metastasis."


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Contact: Jonathan Weil
jweil@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

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