Navigation Links
Stem cells help doctors restore woman’s smile, regenerating bone to hold dental implants
Date:11/5/2014

Durham, NC (PRWEB) November 05, 2014

Half of all traumatic injuries to the face result in a loss of teeth and the surrounding tissue and bone that once supported them, which in turn makes these types of injuries very debilitating and difficult to treat. But in a new study published in the latest issue of STEM CELLS Translational Medicine, doctors at the University of Michigan School of Dentistry (UMSoD), Ann Arbor, have found a new way to regenerate a patient’s jawbone through the use of stem cells.

The procedure, done under local anesthesia, significantly speeds up the healing time relative to that of traditional bone grafting while allowing a patient to experience only a minimal amount of pain.

Part of a larger clinical trial, the findings highlighted in this issue focus on a 45-year-old woman missing seven front teeth plus 75 percent of the bone that once supported them, the result of a blow to her face five years earlier. She was left with severe functional and cosmetic deficiencies, since the missing bone made it impossible for her to have dental implant-based teeth replacements.

Darnell Kaigler, DDS, MS, PhD, an assistant professor of dentistry in the Department of Periodontics and Oral Medicine, was a lead member of the study team. "In small jawbone defects of the mouth created after teeth were extracted, we have placed gelatin sponges populated with stem cells into these areas to successfully grow bone."

Since the sponge material is soft, it does not work in larger areas. Thus, he and his team of researchers decided to try b-tricalcium phosphate (b-TCP) as a scaffold upon which to place the cells instead. "For treating larger jawbone defects, it is important to have a scaffold material that is rigid and more stable to support bone growth," he explained.

They then placed the b-TCP scaffold, which had been seeded with a mixed population of bone marrow-derived autologous stem and progenitor cells 30 minutes prior to treatment at room temperature, into the defective area of the patient’s mouth during a procedure that requires only local anesthesia. Four months later, 80 percent of her missing jawbone had been regenerated, allowing them to proceed with placing oral implants that supported a dental prosthesis to once again give her a complete set of teeth.

Study team member Sharon Aronovich, DMD, FRCD(C), a clinical assistant professor of dentistry in the Department of Oral and Maxillofacial Surgery at the UMSoD, said, “I am very grateful to all the patients and researchers that participated in this study. Thanks to everyone's efforts, we are one step closer to providing patients with a minimally invasive option for implant-based tooth replacement.”

“As the first report to describe a cell therapy for craniofacial trauma reconstruction, this research serves as the foundation for expanded studies using this approach,” said Anthony Atala, M.D., Editor-in-Chief of STEM CELLS Translational Medicine and director of the Wake Forest Institute for Regenerative Medicine.

###

The article, “Optimized Cell Survival and Seeding Efficiency for Craniofacial Tissue Engineering Using Clinical Stem Cell Therapy,” can be accessed at http://www.stemcellstm.com.

About STEM CELLS Translational Medicine: STEM CELLS TRANSLATIONAL MEDICINE (SCTM), published by AlphaMed Press, is a monthly peer-reviewed publication dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology. By bridging stem cell research and clinical trials, SCTM will help move applications of these critical investigations closer to accepted best practices.

About AlphaMed Press: Established in 1983, AlphaMed Press with offices in Durham, NC, San Francisco, CA, and Belfast, Northern Ireland, publishes two other internationally renowned peer-reviewed journals: STEM CELLS® (http://www.StemCells.com), celebrating its 32nd year, is the world's first journal devoted to this fast paced field of research. The Oncologist® (http://www.TheOncologist.com), also a monthly peer-reviewed publication, entering its 19th year, is devoted to community and hospital-based oncologists and physicians entrusted with cancer patient care. All three journals are premier periodicals with globally recognized editorial boards dedicated to advancing knowledge and education in their focused disciplines.

Read the full story at http://www.prweb.com/releases/2014/11/prweb12303402.htm.


'/>"/>
Source: PRWeb
Copyright©2014 Vocus, Inc.
All rights reserved

Related medicine news :

1. NSAIDs prevent colon cancer by inducing death of intestinal stem cells that have mutation
2. Phayronet Research of Drug Delivery Medicines to Sick Cells
3. Cell division, minus the cells
4. Decoding the emergence of metastatic cancer stem cells
5. Scientists trigger self-destruct switch in lung cancer cells
6. Scientists Create Tiny Stomachs From Stem Cells
7. Study gives new view on how cells control what comes in and out
8. Bio-inspired nano-cocoons offer targeted drug delivery against cancer cells
9. Experts from CNIO discover shining cells responsible for developing tumors
10. New Mount Sinai Research Indicates Cells From Placentas are Safe for Patients with Multiple Sclerosis
11. Biochemists solve address problem in cells that leads to lethal kidney disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/9/2020)... BOSTON (PRWEB) , ... August 10, 2020 , ... Dr. ... New England College of Optometry (NECO). Dr. Abraham will be leading the drive to ... has also signed on to the 13% Promise, a new initiative led by Black ...
(Date:8/7/2020)... Mich. (PRWEB) , ... August 07, 2020 , ... As ... the COVID-19 pandemic during this past spring, The Bengtson Center team decided to temporarily ... may be seen on an individual basis. With the offices now open again, the ...
(Date:8/7/2020)... ... August 07, 2020 , ... ... the Physician Fee Schedule proposed rule for the 2021 calendar year. The proposal ... devaluing the procedures they perform which help return patients suffering from joint disease ...
(Date:8/5/2020)... , ... August 05, 2020 , ... ... Emotional Learning (SEL) program, has been named to the inaugural list of Best ... (AASL). , This recognition honors electronic resources that provide enhanced learning and ...
(Date:8/5/2020)... , ... August 05, 2020 , ... AdventHealth Carrollwood has ... safely reopening for class on Monday, August 12, 2020. AdventHealth provided the school with ... of COVID-19 in the classroom setting. , “We are taking extra steps in ...
Breaking Medicine News(10 mins):
(Date:8/7/2020)... ... August 07, 2020 , ... Death Midwifery returns death to its ... Death Midwife shepherds individuals toward a conscious dying experience; guides loved ones in ... a vigil and funeral at home. They offer compassionate support to individuals and their ...
(Date:8/5/2020)... ... August 04, 2020 , ... Alpine ... and has continued to refine their medical device assessment and penetration testing ... device manufacturing facilities to provide testing onsite, at client facilities. Due to ...
(Date:8/5/2020)... ... 2020 , ... The Pulmonary Wellness Foundation (PWF), a New York City-based nonprofit ... three decades, today announced the launch of the nation’s first online COVID Rehabilitation & ... Sunday, August 2 and meets on Wednesday and Sunday evenings at 7 pm ET. ...
Breaking Medicine Technology: