Navigation Links
Stem cells give clues to understanding cancer and make breakthrough in childhood leukaemia
Date:2/13/2008

ake tumour samples and grow them in a variety of ways, said Professor Ruiz i Altaba. When we treat them with inhibitors that block the Shh-Gli pathway, they all respond, demonstrating that every tumour we have tested requires this signalling pathway.

Professor Ruiz i Altaba added, Hedgehog signalling appears to be involved in many kinds of stem cells and many kinds of cancers. Specifically, Gli-1 seems to be important for the proliferation of tumour cells and especially for the proliferation and perpetuation of cancer stem cells. We think the Gli code, the sum of all Gli activities, is locked in a hyperactivating state in cancer, and if we can revert it to a repressive state, this could provide a possible therapeutic approach.

Meanwhile Dr Manel Esteller of the Spanish National Cancer Research Centre (CNIO) in Madrid has been investigating the way that genes in cancer cells and stem cells are modified by a process called methylation[2].

In a cell not all of the genes are active. Some are rendered silent by the attachment of chemical entities called methyl groups. This is one of the mechanisms by which a cell can switch genes on and off. It has become clear that the pattern of DNA methylation is one key difference between a cell that has become specialised that is differentiated and one that remains undifferentiated.

We have studied plant DNA and have seen that in undifferentiated tissue one particular region of the DNA is always unmethylated, Dr Esteller told the meeting. In differentiated tissue this same region is methylated. If we take the undifferentiated cell and add the methylated gene we get differentiation.

A similar system appears to operate in human cells. And in some cancer cells there are particular patterns of DNA methylation. We have seen that in some leukaemias there is a gene involved in differentiation that is methylated, Dr Esteller said. In cultured cells we see that if we put the unmethylated gene b
'/>"/>

Contact: Dr. Fiona Kernan
fkernan@esf.org
33-388-762-180
European Science Foundation
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
2. Brain cells work differently than previously thought
3. Embryonic Stem Cells Repair Human Heart
4. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
5. Circulating fats kill transplanted pancreas cells, study shows
6. Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
7. Melanoma drug revs immune cells but cancer cells ignore it
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Embryonic stem cells used to grow cartilage
10. Molecular probe paints cancer cells in living animals, Stanford researchers find
11. USC researcher identifies stem cells in tendons that regenerate tissue in animal model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... WASHINGTON (May 22, 2013)Today the George Washington ... Health Services (SPHHS) announced the launch of ... Immigrant/Refugee Health, a collaboration between SPHHS, the ... and other community partners. This university-community partnership ... disproportionately affect Latino communities through research, mutual ...
(Date:5/21/2013)... 21, 2013 Patients of Dr. Michael Shenk ... lost teeth due to gum disease and would like permanent ... disease treatment with laser gum surgery. Gum disease ... highest success rate out of all tooth replacement options. ... relatively new procedure cleared by the Food and Drug Administration ...
(Date:5/21/2013)... practice transformation on a large scale is the ... at achieving better outcomes, better value and better ... toward the patient-centered medical home model offers a ... U.S. Department of Health and Human Services, Agency ... to learn more about the processes and determinants ...
(Date:5/21/2013)... New York, New York (PRWEB) May 21, 2013 ... dedicated to protecting the rights of victims injured by ... the Journal of Bone & Joint Surgery on May ... (MRI) can be used to identify complications that occur ... have any symptoms of failure. ( http://www.jbjs.org/article.aspx?articleid=1684770 ) ...
(Date:5/21/2013)... Artisan Business Group is to ... Conference in Long Beach, California on May 30, ... alternative finance through EB-5 immigrant investors program. The ... economic information, and updates to project developers, regional ... EB-5 industry. , "Our goal is to ...
Breaking Medicine News(10 mins):Health News:GW launches center to address health disparities in the Latino immigrant community 2Health News:GW launches center to address health disparities in the Latino immigrant community 3Health News:Shenk Dental Care Stimulates Bone Growth for Gum Disease Patients Seeking Dental Implants with Laser Gum Surgery in Atlanta, GA 2Health News:AHRQ-funded journal supplement offers lessons on primary care practice transformation 2Health News:AHRQ-funded journal supplement offers lessons on primary care practice transformation 3Health News:AHRQ-funded journal supplement offers lessons on primary care practice transformation 4Health News:AHRQ-funded journal supplement offers lessons on primary care practice transformation 5Health News:AHRQ-funded journal supplement offers lessons on primary care practice transformation 6Health News:Parker Waichman LLP Comments on New Study Showing that MRI is Useful for Predicting Failure of Metal-on-Metal Hip Implants 2Health News:Parker Waichman LLP Comments on New Study Showing that MRI is Useful for Predicting Failure of Metal-on-Metal Hip Implants 3Health News:Artisan Business Group to Host EB-5 Investment Conference in Long Beach, California 2
... When people receive brief telephone-based psychotherapy soon after starting ... months after their first session. So concludes a Group ... Clinical Psychology. ,This paper describes one more ... American Medical Association (JAMA) report on the same random ...
... Nursing found that 33% of women in UK experience painful intercourse ... had some kind of sex related problems after child birth. ... in Asian women, older women and in women who had larger ... women who had a Caesarean, 34% who had a normal birth ...
... with Amyotrophic Lateral Sclerosis (ALS), most often spouses, are ... not the case for the people they are caring ... there’s evidence a caregiver’s mental status greatly influences ALS ... psychological condition should not be overlooked when planning ALS ...
... has been found to help reduce the high incidence of ... study. ,The two-year study involved 242 elderly men ... received the drug risedronate and vitamin D2. The remaining men ... found the men taking risedronate were three times less likely ...
... Guillermo Caravotta, whose AIDS documentary "Second Life" was released ... attached// to the disease than the disease itself. ... only to South Africa. However, the stigma and discrimination ... Mumbai-based Caravotta, an Italian doctor of Argentine origin. ...
... have an ultra-modern hospital in the campus with financial aid ... Embassy of Saudi Arabia Tuesday signed an agreement to set ... an investment of Rs.22.5 million. ,The memorandum of ... and the Saudi embassy authorities at the university here. ...
Cached Medicine News:Health News:Phone-based Therapy Eases Depression Long Term 2Health News:Phone-based Therapy Eases Depression Long Term 3Health News:Increased Depression, Burden, Reported in Family Caregivers of ALS Patients 2Health News:Doctor's AIDS Documentary Focus on Stigma and Discrimination 2
(Date:5/21/2013)... RICHLAND, Wash. , May 21, 2013  IsoRay, ... announced today that it has entered into an exclusive ... of IsoRay,s complete product line in Greece ... innovator in seed brachytherapy and medical radioisotope applications for ... cancer and gynecologic ("gyn") cancer. IASIS ...
(Date:5/21/2013)... MOUNTAIN VIEW, Calif. , May 21, 2013 ... the design and manufacture of wireless personal healthcare ... to broaden its reach, announcing the release of ... of wireless blood pressure monitors and scales: the ... Tracker. (Photo: http://photos.prnewswire.com/prnh/20130521/SF17618 ) ...
(Date:5/21/2013)... FOREST HILLS, N.Y. , May 21, 2013 /PRNewswire/ ... video monitoring system used to measure hand-washing compliance at ... , by introducing cameras in operating rooms at ... (Photo: http://photos.prnewswire.com/prnh/20130521/NY17810 ) The new ... real-time feedback in their operating rooms (ORs), the first ...
Breaking Medicine Technology:IsoRay Announces A New International Distributor For Greece 2IsoRay Announces A New International Distributor For Greece 3iHealth Lab adds new products and partners to mobile personal healthcare offering 2iHealth Lab adds new products and partners to mobile personal healthcare offering 3North Shore-LIJ Extends Use of 3rd Party Remote Video Auditing into ORs 2North Shore-LIJ Extends Use of 3rd Party Remote Video Auditing into ORs 3North Shore-LIJ Extends Use of 3rd Party Remote Video Auditing into ORs 4
... , THE WOODLANDS, Texas , Feb. ... ), a biopharmaceutical company focused on discovering and developing breakthrough treatments ... Ph.D. , Lexicon,s president and chief executive officer, will present at ... on Monday, February 8, 2010 at 9:30 ...
... , BATESVILLE, Ind. , Feb. 3 , ... , Reported diluted earnings per share were $0.31 ... share of $0.23 in the prior year , ... , Company updates annual guidance for fiscal year 2010:  Reaffirms ...
Cached Medicine Technology:Lexicon Pharmaceuticals to Present at the 12th Annual BIO CEO & Investor Conference 2Lexicon Pharmaceuticals to Present at the 12th Annual BIO CEO & Investor Conference 3Hill-Rom Reports Double Digit Earnings Per Share Growth for First Quarter 2Hill-Rom Reports Double Digit Earnings Per Share Growth for First Quarter 3Hill-Rom Reports Double Digit Earnings Per Share Growth for First Quarter 4Hill-Rom Reports Double Digit Earnings Per Share Growth for First Quarter 5Hill-Rom Reports Double Digit Earnings Per Share Growth for First Quarter 6Hill-Rom Reports Double Digit Earnings Per Share Growth for First Quarter 7Hill-Rom Reports Double Digit Earnings Per Share Growth for First Quarter 8Hill-Rom Reports Double Digit Earnings Per Share Growth for First Quarter 9Hill-Rom Reports Double Digit Earnings Per Share Growth for First Quarter 10Hill-Rom Reports Double Digit Earnings Per Share Growth for First Quarter 11Hill-Rom Reports Double Digit Earnings Per Share Growth for First Quarter 12Hill-Rom Reports Double Digit Earnings Per Share Growth for First Quarter 13Hill-Rom Reports Double Digit Earnings Per Share Growth for First Quarter 14Hill-Rom Reports Double Digit Earnings Per Share Growth for First Quarter 15Hill-Rom Reports Double Digit Earnings Per Share Growth for First Quarter 16
Single-Piece PMMA Intraocular Lenses....
Single Piece PMMA Lens (Refractive and Bifocal). Anterior chamber Lens....
Hydrophilic Acrylic Intraocular Lens (Refractive and Bifocal). Anterior Chamber Lens....
STABIBAG Hydrophilic Acrylic Lens....
Medicine Products: