Navigation Links
Stem cells from cord blood could help repair damaged heart muscle
Date:10/13/2011

At least 20 million people survive heart attacks and strokes every year, according to World Health Organisation estimates, but many have poor life expectancy and require continual costly clinical care. The use of patient's own stem cells may repair heart attacks, although their benefit may be limited due to scarce availability and ageing. The researchers have found heart muscle-like cells grown using stem cells from human umbilical cord blood could help repair heart muscle cells damaged by a heart attack.

The study, led by Professor Raimondo Ascione, Chair of Cardiac Surgery & Translational Research in the School of Clinical Sciences at the University of Bristol, is published online in Stem Cell Reviews & Reports.

The study, funded by the British Heart Foundation (BHF) and the National Institute for Health Research (NIHR), found that it is possible to expand up to seven-fold, in vitro, rare stem cells (called CD133+) from human cord blood and then grow them into cardiac muscle cells.

The findings could have major implications on future treatment following a heart attack given that cells obtained from adults following a heart attack may be less functional due to ageing and risk factors.

Professor Ascione said: "We believe our study represents a significant advancement and overcomes the technical hurdle of deriving cardiac muscle-type cells from human cord blood. The method we have found has the attributes of simplicity and consistency. This will permit more robust manipulation of these cells towards better cell homing and cardiac repair in patients with myocardial infarction.

"Our research suggests that in the future stem cells derived from cord blood bank facilities might be used for repair after a heart attack."

The study focused on a rare type of stem cells, called CD133+, which is also present in adult bone marrow. There is also strong experimental evidence these cells derived from bone marrow may help with the regeneration of damaged heart muscle.

Professor Jeremy Pearson, Associate Medical Director at the British Heart Foundation, said: "Regenerative medicine research in the lab, alongside studies of patients, is absolutely crucial. Right now, the damage to the heart caused by heart attack cannot be reversed. Through research like this across the UK, we hope to bring our vision of mending broken hearts to reality.

"There has been interest for some time in the potential use of blood from the umbilical cord as a source of stem cells for therapy in a variety of diseases. This study has shown for the first time that it's possible to turn cord blood stem cells into cells that look like heart muscle, in the lab. The results are encouraging, but there are still lots of questions to answer before we'll know whether these cells can be used successfully for heart repair in patients."

In 2007, the British Heart Foundation (BHF) awarded Professor Ascione, over 200,000 for the world's first clinical trial, TransACT, to test whether bone marrow derived CD133+ stem cells can repair heart muscle cells damaged by a heart attack. Recently, funding for the trial has been extended to 2013.

The double blind placebo-controlled trial has successfully recruited 50 per cent of its patients with no safety concerns. Under Professor Ascione's leadership, 31 out of 60 patients, who have suffered a major heart attack, have been injected to date at the Bristol Heart Institute with stem cells from their own bone marrow or a placebo into their damaged hearts during routine coronary bypass surgery.


'/>"/>
Contact: Joanne Fryer
joanne.fryer@bristol.ac.uk
0044-117-331-8092
University of Bristol
Source:Eurekalert

Related medicine news :

1. New Study Uses Adult Stem Cells in Effort to Save Limbs of Patients with Peripheral Arterial Disease
2. New study suggests stem cells sabotage their own DNA to produce new tissues
3. Attacking cancer cells with hydrogel nanoparticles
4. UCR researcher identifies mechanism malaria parasite uses to spread in red blood cells
5. Pittsburgh Neurosurgeons Explore Use of Drug that Illuminates Brain Tumor Cells To Guide Surgery
6. New tool illuminates connections between stem cells and cancer
7. Bitter melon extract attacks breast cancer cells
8. Heart Stem Cells Move Closer to Human Treatments
9. Notch-blocking drugs kill brain cancer stem cells, yet multiple therapies may be needed
10. Cells of aggressive leukemia hijack normal protein to grow
11. Periodontal pathogens enhance HIV-1 promoter activation in T cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2017)... ... September 22, 2017 , ... PITTSBURGH...Defibrillators are used to treat ... if one isn’t accessible in certain locations, the risk of death can be ... with this idea," said an inventor from Ridgecrest, Calif. , The MOBILE AUTOMATED ...
(Date:9/22/2017)... , ... September 22, 2017 , ... ... SABRE Safe Is Smart Scholarship Sweepstakes.,  , Molli C., a graduate student from ... in Educational Leadership and Administration at St. Thomas University in Miami, Florida, was ...
(Date:9/22/2017)... ... September 22, 2017 , ... First Choice ... celebrating the one year anniversary of its Houston-Fallbrook facility. , “We are ... Facility Medical Director of First Choice Emergency Room Houston-Fallbrook. “It has been a ...
(Date:9/22/2017)... , ... September 22, 2017 , ... ... and more products at customers’ doorstep. According to Smart Mart, customers can now ... stated to offer wearable, and customers can find clothing at discounted prices. Apart ...
(Date:9/21/2017)... ... September 21, 2017 , ... Process Capability Indices for Medical ... p.m. ET, http://www.fdanews.com/processcapabilityindices      , Quality in device manufacturing ... The Quality System Regulation (§820.250), and Devicemakers find themselves staring at a warning ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... NuvoAir (formerly called Pond Healthcare Innovation), ... partnership with Novartis Pharma AG to distribute NuvoAir,s spirometry technology ... leading mobile spirometry platform and Novartis, commitment to address the ... ... ...
(Date:9/6/2017)... 6, 2017  Robert G. Szewc, M.D., is recognized ... in recognition of his contributions to the Medical field.  ... Nephrologist at the practice of Kidney and Hypertension Specialists, ... and hypertension solutions. He has worked in this position ... experience, as well as expertise in kidneys, hypertension, chronic ...
(Date:9/6/2017)... NeuroRx, a clinical stage biopharma company developing the first oral ... granted Fast Track status by the US Food and Drug ... by NRX-101 (D-cycloserine + lurasidone). The company will shortly begin ... targeting patients who are admitted to Emergency Departments with ASIB ... ...
Breaking Medicine Technology: