Navigation Links
Stem cells could halt osteoporosis, promote bone growth
Date:3/4/2009

This release is available in French.

Montreal, March 4th, 2009 While interferon gamma sounds like an outer space weapon, it's actually a hormone produced by our own bodies, and it holds great promise to repair bones affected by osteoporosis. In a new study published in the journal Stem Cells, researchers from the Research Institute of the McGill University Health Centre explain that tweaking a certain group of multipotent stem cells (called mesenchymal stem cells) with interferon (IFN) gamma may promote bone growth.

"We have identified a new pathway, centered on IFN gamma, that controls the bone remodelling process both in-vivo and in-vitro," explains Dr. Kremer, the study's lead author and co-director of the Musculoskeletal Axis of the McGill University Health Centre. "More studies are required to describe it more precisely, but we are hopeful that it could lead to a better understanding of the underlying causes of osteoporosis, as well as to innovative treatments."

From cell culture to animal model

"First, we stimulated cultured mesenchymal stem cells to turn into bone cells (osteoblasts) in-vitro," says Dr Richard Kremer, a Professor with the McGill's Faculty of medicine. "We realised that this differentiation process involved IFN gamma-related genes, but also that these bone cells precursors could both be stimulated by IFN gamma and produced IFN gamma."

The next step was to move to an animal model where IFN gamma effect is blocked by inactivating its receptor, a model called IFN gamma receptor knock-out. Bone density tests, comparable to those used to diagnose people with osteoporosis, were conducted. The results revealed that these animals have significantly lower bone mass than their healthy counterparts In addition, their mesenchymal stem cells have a decreased ability to make bone. "These finding
'/>"/>

Contact: Isabelle Kling
isabelle.kling@muhc.mcgill.ca
514-843-1560
McGill University Health Centre
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
2. Brain cells work differently than previously thought
3. Embryonic Stem Cells Repair Human Heart
4. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
5. Circulating fats kill transplanted pancreas cells, study shows
6. Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
7. Melanoma drug revs immune cells but cancer cells ignore it
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Embryonic stem cells used to grow cartilage
10. Molecular probe paints cancer cells in living animals, Stanford researchers find
11. USC researcher identifies stem cells in tendons that regenerate tissue in animal model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... by volunteering are getting more out of it than ... health boost! , A new study, led ... and published online this week in Psychological Bulletin ... at all the available peer-reviewed evidence regarding the psychosocial ... Lead investigator Dr. Nicole Anderson, together with scientists from ...
(Date:8/29/2014)... New York, NY (PRWEB) August 29, 2014 ... industry experienced sparse revenue growth over the ... instability. During the recession, consumers had less disposable ... from grocery stores and visited restaurants less frequently. ... fast food establishments declined, hindering revenue growth. “After ...
(Date:8/29/2014)... September yoga month was created by the Yoga Health ... benefits. To support this Ekhart Yoga is offering those ... , This 4 week guided online yoga program is ... yoga regularly from their own home. Led by Esther ... for all levels, and the dynamic classes will help ...
(Date:8/29/2014)... Work is the recipient of a ... Drug Abuse (NIDA) at the National Institutes of Health (NIH) ... use. Additionally, the grant provides resources to create the infrastructure ... use has increased steadily since 2007 according to NIDA, as ... and more available opioid. , A primary project at ...
(Date:8/29/2014)... Lincoln, R.I. (PRWEB) August 29, 2014 A home ... can crop up if unaddressed. That’s why Amica Insurance is sharing ... The National Safety Council suggests taking the following safety measures: , ... and disinfectants – in their original containers, and keep them away ... on a wall bracket near an exit. , Bathroom ...
Breaking Medicine News(10 mins):Health News:Evidence mounting that older adults who volunteer are happier, healthier 2Health News:Fruit and Vegetable Wholesaling in Canada Industry Market Research Report Now Available from IBISWorld 2Health News:Fruit and Vegetable Wholesaling in Canada Industry Market Research Report Now Available from IBISWorld 3Health News:Ekhart Yoga Launches the Yoga Month Challenge 2Health News:$1.25 million NIH grant to aid research on impact of heroin use 2Health News:Improve Home Safety with Tips from Amica Insurance 2
... answer in ensuring safe patient use of opioid medications ... prescribing and dispensing medications may fail to protect patients ... best be accomplished by conducting a failure mode and ... designing systems for preventing medication errors, told a public ...
... WASHINGTON, May 28 A new statewide poll ... Congress passing a bill to give the U.S. Food and ... The U.S. Senate is expected to debate this issue next ... role in determining whether Congress will finally pass this life-saving ...
... plays a key role in visualization, study finds , , ... activate areas of the brain triggered when people look ... process information about objects using different types of sensory ... the University of Birmingham in the United Kingdom studied ...
... 20 pounds , , THURSDAY, May 28 (HealthDay News) -- ... to between 11 and 20 pounds to safeguard their ... updated expert guidelines. , That level of gestational weight ... women and reflects the concern over the rising number ...
... supplier data to the Global Data Synchronization Network ... other data subscribers; market adoption of the healthcare-focused ... /PRNewswire/ -- GHX, LLC has ... healthcare-focused data pool certified by GS1,s Global Data ...
... available in French . , Montreal, May ... four times per week increases the risk of binge drinking, ... in the journal Addiction . Researchers from the Universit ... drinking habits of Canadians and found that frequent alcohol consumption ...
Cached Medicine News:Health News:Process for Planning Safe Pain Treatment Outlined in Presentation at FDA Meeting 2Health News:New Mississippi Poll: Voters Strongly Support FDA Regulation of Tobacco Products 2Health News:New Mississippi Poll: Voters Strongly Support FDA Regulation of Tobacco Products 3Health News:Brain Can 'See' Objects Through Touch 2Health News:Experts Urge Less Weight Gain for Obese Women in Pregnancy 2Health News:Experts Urge Less Weight Gain for Obese Women in Pregnancy 3Health News:GHX Launches the Health ConneXion(TM) GDSN-Certified Data Pool to Accelerate Use of GS1 Standards in Healthcare 2Health News:GHX Launches the Health ConneXion(TM) GDSN-Certified Data Pool to Accelerate Use of GS1 Standards in Healthcare 3Health News:Daily alcohol intake can lead to binge drinking 2
(Date:8/28/2014)... -- Rigrodsky & Long, P.A.: , Do you, or ... )? , Did you purchase your shares before September ... inclusive? , Did you lose money in your investment ... discuss your rights? Rigrodsky & Long, ... J. MacFall , announces that a complaint has been filed in ...
(Date:8/28/2014)... YORK , Aug. 28, 2014 ... is available in its catalogue: North ... http://www.reportlinker.com/p02343464/North-America-Laparoscopes-Market-Outlook-to-2020.html North America ... GlobalData,s new report, "North America Laparoscopes Market Outlook ... North America Laparoscopes market. The report provides value, ...
(Date:8/28/2014)... Aug. 28, 2014 /PRNewswire-iReach/ -- EDGE Orthopaedics, a ... is excited to announce they have received their ... System and REDUCE Fracture Plating System. ... to support multiple indications within the mid-foot. The ... Metatarsophalangeal (MTP), Calcaneal-Cuboid (CC), Talonavicular (TN) and Evans ...
Breaking Medicine Technology:Rigrodsky & Long, P.A. Announces A Securities Fraud Class Action Lawsuit Has Been Filed Against Lannett Company, Inc. 2Rigrodsky & Long, P.A. Announces A Securities Fraud Class Action Lawsuit Has Been Filed Against Lannett Company, Inc. 3North America Laparoscopes Market Outlook to 2020 2North America Laparoscopes Market Outlook to 2020 3North America Laparoscopes Market Outlook to 2020 4North America Laparoscopes Market Outlook to 2020 5North America Laparoscopes Market Outlook to 2020 6North America Laparoscopes Market Outlook to 2020 7North America Laparoscopes Market Outlook to 2020 8North America Laparoscopes Market Outlook to 2020 9North America Laparoscopes Market Outlook to 2020 10North America Laparoscopes Market Outlook to 2020 11EDGE Orthopaedics Receives Second FDA Clearance 2
...  Communication channels are becoming increasingly plentiful in today,s ... drive efficient performance, increase profitability and raise consumer ... companies need to identify which external and internal ... best use them. Best Practices, ...
... 2012  Par Pharmaceutical Companies, Inc. (NYSE: ... the acquisition of privately-held Edict Pharmaceuticals Private Limited, ... Par paid $20.5 million at closing and $4.4 ... Edict is a Chennai, India-based developer and manufacturer ...
Cached Medicine Technology:Effective Communication Options to Increase Organizational Effectiveness 2Par Pharmaceutical Completes Acquisition of Edict Pharmaceuticals 2
... (CDN) closed dilution nebulizer allows the clinician to ... additional gas into the side port for precise ... ,The P31000N, for normal flow patients, delivers 8-12 ... in the side port. For your high flow ...
Rotary Piston Mini Nebulizer...
... is a disposable lighting system that provides ... and deep surgical incisions. The system features ... light rod designed to illuminate the tip ... The system can be connected to existing ...
... HELION family consists of four models in ... - to ensure you find the right ... singly or in a combination of two ... the standard design with an on/off switch ...
Medicine Products: