Navigation Links
Stem cells could halt osteoporosis, promote bone growth
Date:3/4/2009

This release is available in French.

Montreal, March 4th, 2009 While interferon gamma sounds like an outer space weapon, it's actually a hormone produced by our own bodies, and it holds great promise to repair bones affected by osteoporosis. In a new study published in the journal Stem Cells, researchers from the Research Institute of the McGill University Health Centre explain that tweaking a certain group of multipotent stem cells (called mesenchymal stem cells) with interferon (IFN) gamma may promote bone growth.

"We have identified a new pathway, centered on IFN gamma, that controls the bone remodelling process both in-vivo and in-vitro," explains Dr. Kremer, the study's lead author and co-director of the Musculoskeletal Axis of the McGill University Health Centre. "More studies are required to describe it more precisely, but we are hopeful that it could lead to a better understanding of the underlying causes of osteoporosis, as well as to innovative treatments."

From cell culture to animal model

"First, we stimulated cultured mesenchymal stem cells to turn into bone cells (osteoblasts) in-vitro," says Dr Richard Kremer, a Professor with the McGill's Faculty of medicine. "We realised that this differentiation process involved IFN gamma-related genes, but also that these bone cells precursors could both be stimulated by IFN gamma and produced IFN gamma."

The next step was to move to an animal model where IFN gamma effect is blocked by inactivating its receptor, a model called IFN gamma receptor knock-out. Bone density tests, comparable to those used to diagnose people with osteoporosis, were conducted. The results revealed that these animals have significantly lower bone mass than their healthy counterparts In addition, their mesenchymal stem cells have a decreased ability to make bone. "These finding
'/>"/>

Contact: Isabelle Kling
isabelle.kling@muhc.mcgill.ca
514-843-1560
McGill University Health Centre
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
2. Brain cells work differently than previously thought
3. Embryonic Stem Cells Repair Human Heart
4. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
5. Circulating fats kill transplanted pancreas cells, study shows
6. Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
7. Melanoma drug revs immune cells but cancer cells ignore it
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Embryonic stem cells used to grow cartilage
10. Molecular probe paints cancer cells in living animals, Stanford researchers find
11. USC researcher identifies stem cells in tendons that regenerate tissue in animal model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2015)... (PRWEB) , ... July 28, 2015 , ... ... announced today that the company is in full support of National Immunization Awareness ... sometimes deadly diseases. To stay protected against serious illnesses like the flu, measles, ...
(Date:7/28/2015)... ... July 16, 2015 (PRWEB) July 28, 2015 , ... ... providing Health insurance quotes to its clients, recently announced the launch of Commercial, ... best suits their specific needs. , Liability automobile insurance policies are one ...
(Date:7/28/2015)... , ... July 28, 2015 , ... ... first fitness studio to measure and produce health outcomes associated with its training ... , Focusing on a small group pre-post study, conducted in early 2015, training ...
(Date:7/28/2015)... ... 28, 2015 , ... OrthAlign, Inc., a privately held medical ... a palm-sized, single-use navigation device for Total Hip Arthroplasty (cup placement, leg length, ... a revolutionary way for Total Knee Arthroplasty surgeries and is now doing it ...
(Date:7/28/2015)... ... ... According to Kxan on June 24th a previously FDA approved blood ... study involving isradipine has garnered national attention and is making drug and alcohol rehabilitation ... alcohol addictions. The study was conducted by the University of Texas. Human trials may ...
Breaking Medicine News(10 mins):Health News:CareMed Urgent & Primary Care Supports National Immunization Awareness Month 2Health News:CareMed Urgent & Primary Care Supports National Immunization Awareness Month 3Health News:Nations Insurance Solutions Announces Auto, Motorcycle, and Commercial Business Insurance Quotes. 2Health News:opaJUMP Launches First Case Study in Thyroid Health: How Rebounding Helped One Woman Stabilize Her Thyroid in Seven Weeks 2Health News:opaJUMP Launches First Case Study in Thyroid Health: How Rebounding Helped One Woman Stabilize Her Thyroid in Seven Weeks 3Health News:opaJUMP Launches First Case Study in Thyroid Health: How Rebounding Helped One Woman Stabilize Her Thyroid in Seven Weeks 4Health News:opaJUMP Launches First Case Study in Thyroid Health: How Rebounding Helped One Woman Stabilize Her Thyroid in Seven Weeks 5Health News:opaJUMP Launches First Case Study in Thyroid Health: How Rebounding Helped One Woman Stabilize Her Thyroid in Seven Weeks 6Health News:opaJUMP Launches First Case Study in Thyroid Health: How Rebounding Helped One Woman Stabilize Her Thyroid in Seven Weeks 7Health News:OrthAlign, Inc. Announces U.S. Commercial Launch of ORTHALIGN PLUS®, the most complete handheld navigation device for use in Total Hip Arthroplasty Surgery 2Health News:OrthAlign, Inc. Announces U.S. Commercial Launch of ORTHALIGN PLUS®, the most complete handheld navigation device for use in Total Hip Arthroplasty Surgery 3Health News:Blood Pressure Medication May be the Key to Treating Addiction 2Health News:Blood Pressure Medication May be the Key to Treating Addiction 3
... Spa Company Taps World,s #1 Aquatic Fitness Expert to, Create Underwater Workout ... ... for AFS, SAN DIEGO, March 7 Dimension One ... its Aquatic,Fitness System, the world,s first underwater gym, at the International,Health, Racquet ...
... Corgenix Medical Corporation,(OTC Bulletin Board: CONX), a worldwide ... exhibiting its AspirinWorks(R) Test at the,American College of ... conference is being held March 12-14 at the ... be on-hand at booth #807 during ACOFP to,answer ...
... body imaging -- positron emission tomography (PET) and magnetic ... first time in a single scanner. , MRI scans ... PET scans -- which follow a radioactive tracer in ... structures, said Simon Cherry, professor and chair of biomedical ...
... anyone over 60 to predict their individual risk of bone ... by the Sydney-based Garvan Institute of Medical Research. , The ... at www.fractureriskcalculator.com , Each person has a unique ... weight, history of prior fracture, number of falls in the ...
... study says; a healthy lifestyle is even better, doctor adds ... start drinking moderate amounts of alcohol in middle age, particularly ... up to 68 percent, compared to nondrinkers, a new study ... consumption was good for the heart, it hadn,t been clear ...
... MGT Capital Investments,Inc. (Amex: MGT ), ... ("HCIT") sector, today commented on the American Cancer,Society,s ... its colon cancer screening guidelines. MGT Capital Investment,s,Medicsight ... exchange under,"MDST," is an industry leader in the ...
Cached Medicine News:Health News:D1 Spas Unveils World's First Underwater Gym at IHRSA 2008 2Health News:D1 Spas Unveils World's First Underwater Gym at IHRSA 2008 3Health News:D1 Spas Unveils World's First Underwater Gym at IHRSA 2008 4Health News:Corgenix to Exhibit AspirinWorks(R) Test at 2008 ACOFP Meeting in Denver 2Health News:Corgenix to Exhibit AspirinWorks(R) Test at 2008 ACOFP Meeting in Denver 3Health News:Launch of Web-based tool to predict risk of bone fracture 2Health News:Even in Middle Age, Starting to Drink May Lower Heart Risks 2Health News:Even in Middle Age, Starting to Drink May Lower Heart Risks 3Health News:MGT Comments on American Cancer Society's Decision to Endorse CT Colonography 2Health News:MGT Comments on American Cancer Society's Decision to Endorse CT Colonography 3Health News:MGT Comments on American Cancer Society's Decision to Endorse CT Colonography 4
(Date:7/28/2015)... ALBANY, New York , July 28, 2015 ... of a new report, titled " Cancer Diagnostics ... Forecast, 2014 - 2020 " . According to this ... at a CAGR of 7.6% during the forecast period of ... was valued at US$100,994.5 million and is expected to be ...
(Date:7/28/2015)... -- Mike Rowe , spokesperson and reality television personality, ... 2015 ThoughtSpot conference and tradeshow, which runs ... Vegas, Nev. Best known for ... Discovery Channel,s, "Dirty Jobs," Mr. Rowe spent a decade traveling ... people whose hard work, sacrifice and value aren,t always recognized. ...
(Date:7/28/2015)... ROCHESTER, N.Y. , July 28, 2015 ... of clinical trial imaging solutions, today announced that it ... the 4:00 p.m. ET market close on Tuesday, August ... chief executive officer, and Jim Groff , chief ... to discuss the company,s financial results and provide a ...
Breaking Medicine Technology:Cancer Diagnostics Market is Expected to Grow at CAGR of 7.6% From 2014 to 2020, to be Worth US$168,649.3 Million by 2020: Transparency Market Research 2Cancer Diagnostics Market is Expected to Grow at CAGR of 7.6% From 2014 to 2020, to be Worth US$168,649.3 Million by 2020: Transparency Market Research 3Cancer Diagnostics Market is Expected to Grow at CAGR of 7.6% From 2014 to 2020, to be Worth US$168,649.3 Million by 2020: Transparency Market Research 4Mike Rowe to Address Community Pharmacists at ThoughtSpot 2015 2VirtualScopics, Inc. Schedules Second Quarter 2015 Financial Results Press Release, Conference Call And Webcast 2VirtualScopics, Inc. Schedules Second Quarter 2015 Financial Results Press Release, Conference Call And Webcast 3
... Even with a steadily improving economy, 130,000 children and families ... meet. This spring, Shire Pharmaceuticals is issuing a "call to action" for ... regional donation drive to benefit Cradles to Crayons. , ... Most Cradles to Crayons recipients have incomes ...
... LOVELAND, Colo. , May 10 Heska Corporation (Nasdaq: HSKA ... Conference on Wednesday, May 12, 2010 .  The presentation will be at The ... City and is scheduled to begin at 9:55 a.m. Eastern Time . ... (Logo:   http://www.newscom.com/cgi-bin/prnh/20000622/HESKALOGO ) , ...
Cached Medicine Technology:Area Residents Can Give a Little, Help A Lot at Shire's BIG GIVE 2
... first identified in 1980 (1) and has only ... appetite (2). PYY is produced by the gut ... and is found to decrease appetite. The main ... circulation is PYY3-36, the N-terminal truncated form of ...
... is the glucuronide conjugate of 3alpha-androstanediol, ... [1,2]. 3alpha-diol G has strong androgenic ... bioactivity of testosterone [2]. Serum 3alpha-diol ... reduction of DHT, and in addition, ...
... as bone Gla protein, is a vitamin ... major component of the noncollagenous bone matrix ... bone, with a small amount produced by ... During bone formation, newly synthesized osteocalcin is ...
... growth factor binding protein 4 (IGFBP-4) is a ... the actions of IGF-I and IGF-II. It is ... molecular weight of 28 kDa. IGFBP-4 has been ... in numerous cell types, including fibroblasts, neuroblastoma, prostate ...
Medicine Products: