Navigation Links
Stem cells and leukemia battle for marrow microenvironment
Date:12/18/2008

Learning how leukemia takes over privileged "niches" within the bone marrow is helping researchers develop treatment strategies that could protect healthy blood-forming stem cells and improve the outcomes of bone marrow transplantation for leukemia and other types of cancer.

In a paper in the journal Science, available early online Dec. 19, 2008, researchers from the University of Chicago Medical Center show that by blocking one of the chemical signals that leukemic cells release, they could help prevent the cells that mature to become red and white blood cells from being shut down by the cancerous invader.

"We found an approach, in our mouse model, that could help protect the cells that give rise to healthy blood cells, and improve their accessibility for use in autologous transplantation," said study author Dorothy Sipkins, MD, PhD, assistant professor of medicine at the University of Chicago Medical Center. "The next step is to confirm this in human studies."

Sipkins and colleagues study the molecular characteristics of tissue microenvironments, or "niches," within the bone marrow where normal, healthy bone marrow stem cells divide and mature. From these niches, the stem cells produce all the different types of blood cells involved in transporting oxygen from the lungs to the rest of the body, fighting off infections and controlling blood clotting.

In patients with leukemia, however, these stem cells lose their powers. Part of the problem is that they are being crowded out by the rapid multiplication and spread of diseased cells as they take over the bone marrow, but this isn't always the explanation.

Sipkins and colleagues have shown that the process is far more complicated, and focused, than simply overcrowding. Using sophisticated microscopy tools, they developed systems to monitor the movements of leukemia cells and hematopoietic progenitor cells (HPCs)--a group of cells that includes stem cells as wel
'/>"/>

Contact: John Easton
john.easton@uchospitals.edu
773-702-6241
University of Chicago Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Low Levels of 2 Enzymes in Ovarian Cancer Cells Shortened Survival
2. Molecular marker identifies normal stem cells as intestinal tumor source
3. Newly discovered esophagus stem cells grow into transplantable tissue, Penn study finds
4. An Achilles heel in cancer cells
5. Special Immune Cells May Be Key to HIV Resistance
6. Moms Cells Prime Fetal Immune System
7. Bone Marrow-Derived Stem Cells May Offer Novel Therapeutic Option for Skin Disorder
8. Bone marrow-derived stem cells may offer novel therapeutic option for skin disorder
9. Dormant stem cells for emergencies
10. UCLA scientists prove endothelial cells give rise to blood stem cells
11. Interferon needed for cells to remember how to defeat a virus, UT Southwestern researchers report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... iFitDress.com, the well-known wedding dress manufacturer and retailer, ... evening gowns . All items in the fresh collection ... $100. , iFitDress.com is among the hardest working ... best to help clients worldwide to keep pace with ... and professional. According to its development manager, all its ...
(Date:8/20/2014)... August 20, 2014 The ... (IBCCES) , an organization recognizing professionals dedicated to ... has announced that with a certificate in ... people on the Autism Spectrum have a way ... quality care. This, in turn, say IBCCES representatives, ...
(Date:8/20/2014)... 20, 2014 Ticket Down is a ... in NYC. In just a week, the U.S. Open Tennis ... Center. The event was originally founded in 1881 and features grass ... was forced to withdrawal from the event because of a wrist ... and will return to New York City with hopes of winning ...
(Date:8/20/2014)... Line: A study in Australia examined patient and ... (a marker of tumor cell growth) in an ... cancer in patients. , Author: ... Victoria, Australia, and colleagues. , Background: The ... cell division) has been connected with prognosis and ...
(Date:8/20/2014)... deploy Ebola vaccines is now, Free content, The ... to a commentary being published early online today in ... authors from Yale School of Public Health write that ... current Ebola outbreak represent a public health crisis that ... Ebola vaccines have been developed in the last decade, ...
Breaking Medicine News(10 mins):Health News:iFitDress.com Releases a New Range of Cheap Evening Gowns 2Health News:National Autism Certificate Credentialing Board IBCCES Increases Job Placement Opportunities for Those Dedicated to Working Within the Autism Spectrum 2Health News:National Autism Certificate Credentialing Board IBCCES Increases Job Placement Opportunities for Those Dedicated to Working Within the Autism Spectrum 3Health News:2014 U.S. Open Tennis Tickets: Ticket Down Slashes Ticket Prices on All US Open Tennis Championship Sessions in New York at Arthur Ashe Stadium 2Health News:2014 U.S. Open Tennis Tickets: Ticket Down Slashes Ticket Prices on All US Open Tennis Championship Sessions in New York at Arthur Ashe Stadium 3Health News:2014 U.S. Open Tennis Tickets: Ticket Down Slashes Ticket Prices on All US Open Tennis Championship Sessions in New York at Arthur Ashe Stadium 4Health News:2014 U.S. Open Tennis Tickets: Ticket Down Slashes Ticket Prices on All US Open Tennis Championship Sessions in New York at Arthur Ashe Stadium 5Health News:Patient, tumor characteristics for high-mitotic rate melanoma 2Health News:News from Annals of Internal Medicine 2
... Taking serious note of doctors using advertisements to lure ... Monday asked the state's medical council to take steps ... education and research minister Tikshan Sood said here that ... but also a violation of the Medical Council Act. ...
... say that they have developed a faster, less expensive ... stretches of DNA. The development of the new technique ... mutant genes, but also from mutations of other DNA ... occur as a consequence of deleting non-gene DNA sequences, ...
... that playing with candy cigarettes may favorably set the ... . , The study, reported in the ... nationally representative sample of 25,887 US adults, the percentages ... current and former smokers vs. 22% in never smokers, ...
... discovery by Fox Chase Cancer Center researchers helps explain ... viral diseases. The research shows lymph nodes are not ... also are the sites where a major fight against ... ,After becoming sick from many viruses, the body becomes ...
... dogs are at risk of suffering broken bones, torn ... owner and pet, there are veterinarians who can ... feet. James Roush, an orthopedic surgeon at the Veterinary ... such veterinarian. ,Roush frequently performs orthopedic surgeries ...
... a team of Emory University scientists have found a ... mutations recently identified in Parkinson disease development. These new findings ... provide a target for drug therapies to treat the disease. ... central nervous system resulting from the loss of neurons in ...
Cached Medicine News:Health News:Boffins Develop New Technique to Hunt Illness-causing Mutants in Non-gene DNA 2Health News:The Danger in Candy Cigarettes 2Health News:Memory T Cells Protect the Body from Viruses 2Health News:Some Common Human Injuries Also Common in Dogs 2Health News:Some Common Human Injuries Also Common in Dogs 3Health News:Parkinsons Disease Protein Pathway Identified 2
(Date:8/20/2014)... YORK , Aug. 20, 2014 ... is available in its catalogue: Global ... http://www.reportlinker.com/p01375204/Global-Coatings-for-Medical-Devices-Industry.html This report ... Devices in US$ Million by the following Product ... Nanotechnology Coatings. The report provides separate comprehensive analytics ...
(Date:8/20/2014)... PHOENIX , Aug. 20, 2014 ... cutting-edge next-generation sequencing and proteomic diagnostics and biomarker ... a collaboration with TESARO, Inc.  Paradigm will use ... samples from clinical trials to better predict which ... TSR-011.  This may lead to more successful clinical trial ...
(Date:8/20/2014)... ApolloDx™ today announced it will unveil and ... event at the company,s office in Salt ... The event, which will start at 10:00 a.m., will ... .    "We believe our mobile diagnostic ... , Co-Founder and Managing Partner of ApolloDx. In addition ...
Breaking Medicine Technology:Global Coatings for Medical Devices Industry 2Global Coatings for Medical Devices Industry 3Global Coatings for Medical Devices Industry 4Global Coatings for Medical Devices Industry 5Global Coatings for Medical Devices Industry 6Global Coatings for Medical Devices Industry 7Global Coatings for Medical Devices Industry 8Global Coatings for Medical Devices Industry 9Global Coatings for Medical Devices Industry 10Global Coatings for Medical Devices Industry 11Global Coatings for Medical Devices Industry 12Global Coatings for Medical Devices Industry 13Global Coatings for Medical Devices Industry 14Global Coatings for Medical Devices Industry 15Global Coatings for Medical Devices Industry 16Global Coatings for Medical Devices Industry 17Global Coatings for Medical Devices Industry 18Global Coatings for Medical Devices Industry 19Global Coatings for Medical Devices Industry 20Global Coatings for Medical Devices Industry 21Paradigm Announces Molecular Profiling Collaboration with TESARO, Inc. 2
... WuXi PharmaTech (Cayman) Inc. (NYSE: WX ), ... company with operations in China and the United States, ... the third quarter of 2011 after the New York ... will be Friday morning, November 11, 2011 Shanghai time). ...
... 2011 Philips Respironics, a unit of Royal Philips ... treating and managing the full spectrum of sleep and ... kind at Medtrade 2011. The largest national educational and ... (HME) industry kicks off this week at Georgia World ...
Cached Medicine Technology:WuXi PharmaTech Schedules Third-Quarter 2011 Earnings Release 2Philips Respironics Unveils "Pathway to Better Outcomes" for Home Health Care 2Philips Respironics Unveils "Pathway to Better Outcomes" for Home Health Care 3Philips Respironics Unveils "Pathway to Better Outcomes" for Home Health Care 4
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: