Navigation Links
Stem cells and cancer: Scientists investigate a fine balancing act
Date:4/11/2008

Speaking today at the UK National Stem Cell Network Annual Science Meeting in Edinburgh, Professor Silvia Marino shows how the mechanisms normally involved in balancing different functions of stem cells may also contribute to cancer. Her team from Barts and the London School of Medicine and Dentistry is currently delving into these mechanisms to understand how stem cells are normally regulated and what role they may play in malignant brain tumours. This work has been funded by Cancer Research UK, Oncosuisse, Barts and the London Charity, Ali's Dream and Charlie's Challenge.

Professor Marino said: "Stem cells are present in the adult brain where they normally play a role in repair and regeneration. We want to know whether brain cancer can originate from problems in the regulation of these cells. Moreover, it is becoming increasingly clear that tumours maintain themselves with mechanisms similar to the ones used by stem cells. We want to understand whether differences can be identified between normal stem cells and cancer stem cells. If this is the case, new drugs can be developed to specifically kill the cells maintaining and propagating the tumour without harming normal stem cells."

In the body it is vital that a balance is struck between maintaining numbers of stem cells with making new stem cell derived tissues. This is important in embryonic development and also in preserving healthy adult tissues. If the balance is wrong then disease can arise. Cancer can result from stem cells dividing too much, leading to an excess of new cells. But if stem cells do not divide to replenish the stocks for renewal and repair then the result can be ageing and possibly degenerative diseases.

Professor Marino's group works to identify the mechanisms involved in maintaining this balance and assess whether similar mechanisms can possibly contribute to the formation and maintenance of malignant brain tumours. For example, research to date shows that a gene called Bmi1 is important for maintaining stocks of stem cells and without it the stocks of stem cells are depleted. And importantly this gene is overactive in various cancers including brain tumours.


'/>"/>

Contact: Matt Goode
ukpo@uknscn.org
01-793-413-355
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Related medicine news :

1. Embryonic stem cells could help to overcome immune rejection problems
2. Blood vessels: The pied piper for growing nerve cells
3. Cells on path to becoming mature T-cells more flexible than commonly thought
4. Module map links embryonic stem cells and cancer stem cells
5. Cancer Stem Cells Created in Lab
6. Scientists Block Prostate Cancer Cells Spread
7. Blocking the effect of inflammation-causing cells lowered prostate cancer cells invasion
8. Reprogrammed Cells Reduce Parkinsons Symptoms
9. Identification of dopamine mother cells could lead to future Parkinsons treatments
10. Leaky blood vessels open up nerve cells to toxic assault in Lou Gehrigs disease
11. Nanomachine Releases Anticancer Drugs Inside Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... U.S. Surgeon General, Dr. Vivek Murthy, ... Murthy explains how he was inspired to practice medicine at an early age by ... about more than making diagnoses and prescribing medicine,” he states. “It is about building ...
(Date:12/2/2016)... York, NY (PRWEB) , ... December 02, 2016 , ... ... high school and while 84 percent of parents report speaking with their child about ... pornography and sexually transmitted diseases. , Mediaplanet is proud to announce the launch of ...
(Date:12/2/2016)... ... December 02, 2016 , ... Universal Medical Systems, ... and the first company to offer robotic imaging to veterinary medicine is sponsoring ... # 941 for the American Association of Equine Practitioners 62nd Annual Convention from ...
(Date:12/2/2016)... ... December 02, 2016 , ... "Pro3rd Accents Volume 2 is a ... versatile lower third titles with just a few clicks of the mouse," said Christina ... 30 lower third animations. Choose from various styles with accented animations, rigid boxes, simplistic ...
(Date:12/2/2016)... ... December 02, 2016 , ... Date aired: ... of Type 2 Diabetes: The Owner’s Manual, http://realtimepressrelease.com/press-releases-tagged-with/daryl-wein , Sharon ... of Water, Global Climate Change and Your Health radio program syndicated on Voice ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... bioLytical Laboratories, ein Weltführer bei schnellen Tests für Infektionskrankheiten, hat sein ... eingeführt. Continue Reading ... ... , ... ) bioLytical wurde durch die Clinton Health Access ...
(Date:12/2/2016)... Dec. 2, 2016 Boston Scientific Corporation (NYSE: ... to acquire certain manufacturing assets and capabilities of the ... advanced biological tissue business, as well as a 15% ... million in cash. The Neovasc advanced biological tissue business ... Boston Scientific Lotus™ Valve System. * Upon completion ...
(Date:12/2/2016)... Lianluo Smart Limited (Nasdaq: ... develops, markets and sells medical devices and wearable ... and international markets, recently attended the 2016 ... Progress Forum, co-hosted by the Institute of Interventional ... Guangdong Provincial People,s Hospital and Cardiology Department of ...
Breaking Medicine Technology: