Navigation Links
Stem cells and cancer: Scientists investigate a fine balancing act
Date:4/11/2008

Speaking today at the UK National Stem Cell Network Annual Science Meeting in Edinburgh, Professor Silvia Marino shows how the mechanisms normally involved in balancing different functions of stem cells may also contribute to cancer. Her team from Barts and the London School of Medicine and Dentistry is currently delving into these mechanisms to understand how stem cells are normally regulated and what role they may play in malignant brain tumours. This work has been funded by Cancer Research UK, Oncosuisse, Barts and the London Charity, Ali's Dream and Charlie's Challenge.

Professor Marino said: "Stem cells are present in the adult brain where they normally play a role in repair and regeneration. We want to know whether brain cancer can originate from problems in the regulation of these cells. Moreover, it is becoming increasingly clear that tumours maintain themselves with mechanisms similar to the ones used by stem cells. We want to understand whether differences can be identified between normal stem cells and cancer stem cells. If this is the case, new drugs can be developed to specifically kill the cells maintaining and propagating the tumour without harming normal stem cells."

In the body it is vital that a balance is struck between maintaining numbers of stem cells with making new stem cell derived tissues. This is important in embryonic development and also in preserving healthy adult tissues. If the balance is wrong then disease can arise. Cancer can result from stem cells dividing too much, leading to an excess of new cells. But if stem cells do not divide to replenish the stocks for renewal and repair then the result can be ageing and possibly degenerative diseases.

Professor Marino's group works to identify the mechanisms involved in maintaining this balance and assess whether similar mechanisms can possibly contribute to the formation and maintenance of malignant brain tumours. For example, research to date shows that a gene called Bmi1 is important for maintaining stocks of stem cells and without it the stocks of stem cells are depleted. And importantly this gene is overactive in various cancers including brain tumours.


'/>"/>

Contact: Matt Goode
ukpo@uknscn.org
01-793-413-355
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Related medicine news :

1. Embryonic stem cells could help to overcome immune rejection problems
2. Blood vessels: The pied piper for growing nerve cells
3. Cells on path to becoming mature T-cells more flexible than commonly thought
4. Module map links embryonic stem cells and cancer stem cells
5. Cancer Stem Cells Created in Lab
6. Scientists Block Prostate Cancer Cells Spread
7. Blocking the effect of inflammation-causing cells lowered prostate cancer cells invasion
8. Reprogrammed Cells Reduce Parkinsons Symptoms
9. Identification of dopamine mother cells could lead to future Parkinsons treatments
10. Leaky blood vessels open up nerve cells to toxic assault in Lou Gehrigs disease
11. Nanomachine Releases Anticancer Drugs Inside Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... February 05, 2016 , ... Love is in the air at King ... colors, assortments and packaging. This staple for Valentine’s Day is a must-have, and can ... For Valentine’s Day, not only are long-stem roses available, but also other flower bouquets, ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... stage for new clinical and scientific initiatives have all marked the last 12 ... appointed President and CEO of the nation’s oldest cancer center, Candace S. Johnson, ...
(Date:2/5/2016)... ... February 05, 2016 , ... Francisco ... micro-needling services in their Napa Valley office. The technique utilizes the body’s own ... Dr. Canales and Dr. Furnas, are part of only a select few cosmetic ...
(Date:2/5/2016)... ... ... After years as an active staff surgeon and having served as the director ... transitioned to chief of the Division of Plastic Surgery at what is now known ... began a second three-year term in January of 2016. , The original selection was ...
(Date:2/5/2016)... ... February 05, 2016 , ... In the fourth quarter ... gathered at the La Valencia Hotel in San Diego, California to discuss changes ... the year’s most outstanding franchise, walking away with the coveted David Wright Award ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... India , February 5, 2016 ... a new market research report "Fetal (Labor & Delivery) ... & Antepartum), Warmer, Incubator, Pulse Oximeter, Phototherapy/Jaundice Management Devices, ... published by MarketsandMarkets, This report studies the global market ... market is estimated at USD 6.28 Billion in 2015 ...
(Date:2/4/2016)... 2016 For hospitals considering enrollment in the ... in the program, the Health Resources and Services Administration,s ... , Mega-Guidance , could have significant impact on plans ... September 2016. Essential Insights , Daniel ... summarizes the Mega-Guidance,s key proposed changes, including a new ...
(Date:2/4/2016)... , Feb. 4, 2016  SciClone Pharmaceuticals, ... announced it has entered into a settlement agreement ... (SEC) fully resolving the SEC,s investigation into possible ... Under the terms of the settlement agreement, SciClone ... million, including disgorgement, pre-judgment interest and a penalty.  ...
Breaking Medicine Technology: