Navigation Links
Stem cell treatment may offer option for broken bones that don't heal
Date:6/5/2011

(Embargoed) CHAPEL HILL, N.C. Researchers at the University of North Carolina at Chapel Hill School of Medicine have shown in an animal study that transplantation of adult stem cells enriched with a bone-regenerating hormone can help mend bone fractures that are not healing properly.

The UNC study team led by Anna Spagnoli, MD, associate professor of pediatrics and biomedical engineering, demonstrated that stem cells manufactured with the regenerative hormone insulin-like growth factor (IGF-I) become bone cells and also help the cells within broken bones repair the fracture, thereby speeding the healing. The new findings are presented Sunday, June 5, 2011 at The Endocrine Society's 93rd Annual Meeting in Boston, Massachusetts.

A deficiency of fracture healing is a common problem affecting an estimated 600,000 people annually in North America. "This problem is even more serious in children with osteogenesis imperfecta, or brittle bone disease, and in elderly adults with osteoporosis, because their fragile bones can easily and repeatedly break, and bone graft surgical treatment is often not successful or feasible," Spagnoli said.

Approximately 7.9 million bone fractures occur every year in the United States alone, with an estimated cost of $70 billion. Of these, 10 to 20 percent fail to heal.

Fractures that do not mend within the normal timeframe are called non-union fractures. Using an animal model of a non-union fracture, a "knockout" mouse that lacks the ability to heal broken bones, Spagnoli and her colleagues studied the effects of transplanting adult stem cells enriched with IGF-I. They took mesenchymal stem cells (adult stem cells from bone marrow) of mice and engineered the cells to express IGF-I. Then they transplanted the treated cells into knockout mice with a fracture of the tibia, the long bone of the leg.

Using computed tomography (CT) scanning, the researchers showed that the treated mice had better
'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. Women More Likely to Fail Treatment for Atrial Fibrillation
3. Social Anxiety and Panic - Alternative Treatment to Drugs and Therapy
4. Neuroimaging study may pave way for effective Alzheimers treatments
5. Nanofilm Introduces Clarity Defog It™ Anti Fog Treatment and EcoClens™ Eco-Friendly Lens Cleaner at Vision Expo East
6. Many veterans not getting enough treatment for PTSD
7. Scott & White Memorial Hospital uses device to revolutionize treatment of traumatic aortic injury
8. Allegheny General Hospital Study Demonstrates Safety and Potential Efficacy of Oral Allergy Treatment
9. Charging less for more effective treatments could reduce health care costs while improving health
10. Added Drug Aids MS Treatment
11. PTSD Treatment Still Lacking for Veterans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Wild by Nature, a natural and organic supermarket owned by ... fifth store to be located in West Islip, NY very ... selections of wheat and gluten-free products available. With a growing ... become a one-stop shop for anyone who needs to be ... is a spectrum of disorders, including celiac disease, in which ...
(Date:7/11/2014)... LENEXA, Kan. (PRWEB) July 11, 2014 B. ... to healthcare providers, has been retained to lead a national ... Health System in Bend, Ore. The top executive ... has recently placed more than 900 healthcare executives into organizations. ... medical providers, St. Charles Health System is the largest provider ...
(Date:7/11/2014)... BellasDress, the experienced dressmaker in the ... suppliers when it comes to beach wedding dresses ... of beach wedding outfits in its online shop. Included ... outfits. , BellasDress has been considered as one ... to the company’s senior spokesman, BellasDress provides superb special ...
(Date:7/11/2014)... July 11, 2014 Wearing the school motto ... families, facility and staff came together this past Saturday morning ... Everest community in the Homer Township Independence Day Parade. ... Old Glory. , Everest community recognized the theme ... in red, white and blue. The blue Everest balloons ...
(Date:7/11/2014)... 2014 Growing old was thought of as a ... recent studies, it was shown that many of the “myths” ... As it turns out, the elderly can still live quite as ... with all the time in the world, older people also need ... their passions in the twilight of their lives. This is why ...
Breaking Medicine News(10 mins):Health News:Wild by Nature Opens New Location 2Health News:St. Charles Health System Retains B. E. Smith to Recruit New CNO 2Health News:St. Charles Health System Retains B. E. Smith to Recruit New CNO 3Health News:BellasDress Emerges As Popular Online Supplier Of 2014 Beach Wedding Dresses 2Health News:Everest Academy Participates in the Homer Township Independence Day Parade 2Health News:It’s All Free For Seniors Review, How To Take Advantage of What Life Has to Offer In Old Age – Vinamy.com 2Health News:It’s All Free For Seniors Review, How To Take Advantage of What Life Has to Offer In Old Age – Vinamy.com 3
... IL, Oct. 8 /PRNewswire-FirstCall/ - SXC Health Solutions ... TSX: SXC), a leading provider of,pharmacy benefits management ... recertified to provide PBM services to members,of the ... up of more than 60 large employers, representing ...
... adults seek prescription for,savings amid ailing economy, FRANKLIN LAKES, ... hit the hardest when it comes to the recent,economic crisis, ... MHS ),reveals that the sting in paying for health care ... young adults., According to the new national survey "Feeling ...
... satisfaction thanks to revolutionary computer imaging for http://www.parkercenter.net/plastic_surgery_procedures_rhinoplasty.html ... M. Parker, says "A nose should not draw attention to ... to your overall appearance, gender and ethnicity." , ... ...
... will host the 6th Canadian Annual Meeting (November 5-7; ... issues facing Health Canada, the pharmaceutical industry, health academia, ... ... Horsham, PA (PRWEB) October 8, ...
... as a technological leader in cosmetic skin treatments in New York City. ... one of the latest skin resurfacing treatments to receive FDA approval, to ... ... October 8, 2008 -- The cosmetic surgery and laser treatment industry is ...
... LAKE SUCCESS, N.Y., Oct. 7 IPRO, ... evaluation organizations, has,created a Limited Liability Company ... audit oversight and consulting contracts with managed ... (http://www.logiqual.com ), is now,officially incorporated in New ...
Cached Medicine News:Health News:SXC Health Solutions announces PBM certification from the HR Policy Association 2Health News:SXC Health Solutions announces PBM certification from the HR Policy Association 3Health News:New Survey: Painful Economy Puts Health Care Pinch on Young Adults 2Health News:New Survey: Painful Economy Puts Health Care Pinch on Young Adults 3Health News:New Survey: Painful Economy Puts Health Care Pinch on Young Adults 4Health News:New Survey: Painful Economy Puts Health Care Pinch on Young Adults 5Health News:New Jersey Rhinoplasty Patients Can Now See the Future at The Parker Center for Plastic Surgery New Jersey 2Health News:New Jersey Rhinoplasty Patients Can Now See the Future at The Parker Center for Plastic Surgery New Jersey 3Health News:New Jersey Rhinoplasty Patients Can Now See the Future at The Parker Center for Plastic Surgery New Jersey 4Health News:DIA 6th Canadian Annual Meeting Benefit and Risk Management: An Evolution in Progress 2Health News:Upscale New York City Skin Care Center Juva Offering FDA Approved Fraxel re:fine System 2Health News:IPRO Spins Off Managed Care Review Affiliate 2
(Date:7/10/2014)... Calif. , July 10, 2014 Integrated ... leader in advanced memory and analog IC solutions, today ... on Thursday, July 24, 2014, at 7:00 a.m. Pacific ... financial results for the fiscal 2014 third quarter ended ... call via telephone, dial 1-888-556-4997 before 6:50 a.m. Pacific ...
(Date:7/10/2014)... , July 10, 2014  BC Technical, the largest ... MiE America , Inc., a leading provider of Siemens ... a long-term agreement naming BC Technical as the authorized ... MiE and BC Technical announced today that ... establish BC Technical as the service and systems provider ...
(Date:7/10/2014)... 10, 2014  Decision Resources Group finds that ... (ID) specialists are willing to prescribe Durata,s Dalvance ... use as OPAT, approximately two-thirds of the respondents ... their hospital inpatients. However, our findings indicate that ... initiated on OPAT following hospital discharge, and most ...
Breaking Medicine Technology:BC Technical Partners With MiE America To Be Authorized Provider Of Systems & Service 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3
... for Vidaza versus 26.2 for ... patients on Vidaza compared to ... compared to conventional ... Only epigenetic modifier to show survival benefit in cancer Stratified log-rank p-value = ...
... trial of AKIi-5 as the first human clinical study ... involving the systemic ... Quark Pharmaceuticals, Inc., a,clinical-stage biopharmaceutical company focused on discovering ... positive results from preclinical efficacy studies for its,proprietary systemically-administered, ...
Cached Medicine Technology:Vidaza Significantly Extends Overall Survival by 74% in Phase 3 Trial in Myelodysplastic Syndromes (MDS) 2Vidaza Significantly Extends Overall Survival by 74% in Phase 3 Trial in Myelodysplastic Syndromes (MDS) 3Vidaza Significantly Extends Overall Survival by 74% in Phase 3 Trial in Myelodysplastic Syndromes (MDS) 4Vidaza Significantly Extends Overall Survival by 74% in Phase 3 Trial in Myelodysplastic Syndromes (MDS) 5Vidaza Significantly Extends Overall Survival by 74% in Phase 3 Trial in Myelodysplastic Syndromes (MDS) 6Vidaza Significantly Extends Overall Survival by 74% in Phase 3 Trial in Myelodysplastic Syndromes (MDS) 7Vidaza Significantly Extends Overall Survival by 74% in Phase 3 Trial in Myelodysplastic Syndromes (MDS) 8Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF) 2Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF) 3Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF) 4
The Aaron 800-EU is designed and engineered to be the most reliable and durable desiccator available today....
Sabre 180 is a powerful niche generator....
The Sabre 2400 provides high power performance and key user features to meet today's demanding electrosurgical needs. It is an ideal general-purpose electrosurgical generator....
The Sabre 2400 provides high power performance and key user features to meet today's demanding electrosurgical needs. It is an ideal general-purpose electrosurgical generator....
Medicine Products: