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Stem cell transplantation of therapy-resistant chronic leukemia successful
Date:7/12/2010

The transplantation of stem cells from a healthy donor (allogeneic) offers the chance of cure for patients with an aggressive form of chronic lymphocytic leukemia (CLL), irrespective of genetic prognostic factors and the prior course of the disease. The German CLL Study Group proved this in a multicentric clinical phase II study led by Professor Dr. Peter Dreger, senior consultant and head of the division of stem cell transplantation at the Department of Internal Medicine V at Heidelberg University Hospital. The results were published online in the prominent journal "Blood" at the beginning of July.

CLL is the most frequent form of leukemia in western countries. In many cases, it has a rather benign course. However, there are patients in whom the disease does not respond to the standard treatment with chemotherapy or antibodies. Patients with this high-risk CLL often die within a few years of the diagnosis. For some of these patients, the unfavorable course can be predicted based on the presence of typical chromosomal mutations in leukemia cells (deletion 17p-).

High-risk CLL can be controlled in the long term by allogeneic stem cell transplantation

Investigators at 16 different treatment centers in Germany included a total of 90 patients with high-risk CLL in the current study. For conditioning for transplantation, patients were given a reduced dosage of chemotherapy so that the acute tolerance of the transplantation was very good.

For a large percentage of patients, highly sensitive tests were conducted regularly to detect any remaining leukemia cells after the transplantation. In about half of these patients, no remaining CLL cells were detected in the blood in the long term, which was highly predictive for the lack of recurrence for the follow-up period (up to eight years, on average about four years). This positive result was independent of the genetic risk profile and resistance to certain chemotherapeu
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Contact: Dr. Peter Dreger
peter.dreger@med.uni-heidelberg.de
062-215-68008
University Hospital Heidelberg
Source:Eurekalert

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