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Stem cell transplant in mouse embryo yields heart protection in adulthood
Date:5/14/2009

failure in the adult," the authors state. In utero therapy was introduced 30 years ago to treat congenital defects and has been used successfully since then to improve outcomes after birth, but this study takes the concept one step further.

"In this way, prenatal transplantation of embryonic stem cells expands the scope of traditional retrospective therapy to the previously unexplored prospective protection," the authors note. They conclude that beyond reconstructive surgery, stem cell transplantation in prenatal development could offer an innovative approach for preventing disease.

"This study expands the scope of stem cell therapy including traditional retrospective and preventive cell therapy," says Miodrag Stojković, co-editor of the journal. "Therefore, Stem Cells is very proud to publish this pioneering work which is the very first proof of principle for prevention of adult heart stress intolerance to ischemic injury through preemptive cell based intervention."


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Contact: Sean Wagner
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781-388-8550
Wiley-Blackwell
Source:Eurekalert

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