Navigation Links
Stem cell transplant in mouse embryo yields heart protection in adulthood
Date:5/14/2009

Rochester, Minn. May 14, 2009 - Stem cells play a role in heart muscle rejuvenation by attracting cells from the body that develop into heart muscle cells. They have been successfully used to halt or reverse cardiac injury following heart attack, but not to prevent injury before it occurs.

A new study that delivered embryonic stem cells to mouse embryos in the earliest stages of development found that the resulting mice demonstrated a capacity to recover from cardiac injury in adulthood. The study, which provides the first evidence that preventive regenerative medicine can successfully be used to treat myocardial infarction through prophylactic intervention, is published in Stem Cells.

Led by Dr. Andre Terzic of the Mayo Clinic, researchers injected mouse embryos with embryonic stem cells that had been used to successfully treat ischemic heart disease following heart attack. The resulting animals incorporated between five and 20 percent of labeled stem cell-derived tissue. They were born with no apparent abnormalities, and the tested and control groups had similar overall baseline cardiac disease risk profiles. They also demonstrated similar cardiac performance during the one year follow-up.

Researchers induced cardiac injury in both groups by tying off the left anterior artery, causing complete coronary blockage. The group that had received the embryonic stem cell treatment recovered cardiac function, while the other group deteriorated, demonstrating ischemic myopathy, myocardial scarring and significant pulmonary congestion, which are typically seen in the progression towards heart failure. Overall, the group treated with stem cells displayed a favorable disease course, with superior exercise workload capacity and stress test performance, as well as increased survival.

"Preemptive stem cell-based intervention in utero thus provides a strategy to engineer tolerance, and prevent incidence of life-threatening organ failure in the adult," the authors state. In utero therapy was introduced 30 years ago to treat congenital defects and has been used successfully since then to improve outcomes after birth, but this study takes the concept one step further.

"In this way, prenatal transplantation of embryonic stem cells expands the scope of traditional retrospective therapy to the previously unexplored prospective protection," the authors note. They conclude that beyond reconstructive surgery, stem cell transplantation in prenatal development could offer an innovative approach for preventing disease.

"This study expands the scope of stem cell therapy including traditional retrospective and preventive cell therapy," says Miodrag Stojković, co-editor of the journal. "Therefore, Stem Cells is very proud to publish this pioneering work which is the very first proof of principle for prevention of adult heart stress intolerance to ischemic injury through preemptive cell based intervention."


'/>"/>

Contact: Sean Wagner
journalnews@bos.blackwellpublishing.net
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. INTERMACS: Total Artificial Heart Bridge-to-Transplant Rate 2x Higher at 6 Months Than BiVADS and LVADs
2. Bone marrow stem cell co-transplantation prevents embryonic stem cell transplant-associated tumors
3. United Spinal Association Reports Positive Results of Stem Cell Transplantation to Treat Multiple Sclerosis: Study May be Key to Unlocking a Cure
4. First U.S. Face Transplant Recipient Recounts Ordeal
5. Total Artificial Heart Patient 3rd in the World to Receive Dual Transplants
6. Hair Transplant Office Expands Serviceable Area
7. American Transplant Congress 2009: New Investigator Forum Presents Cutting Edge Research
8. Organ Donor Families, Transplant Recipients Journey to State Capitol to Urge Passage of Key Donor Designation Legislation
9. HIV positive and HIV negative patients have similar survival rates following liver transplant
10. UBC research finds molecular "key" to successful blood stem cell transplants
11. Majority of doctors skeptical of organ transplantation practices in China
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from ... at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center ... care topics including advance care planning, healthcare costs and patient and family engagement. ...
(Date:6/25/2016)... TX (PRWEB) , ... June 25, 2016 , ... ... the United States, named Dr. Sesan Ogunleye, as the Medical Director of its new ... the facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the ... In terms of the latter, setting the bar too high can result in disappointment, ... just slow progress toward their goal. , Research from PsychTests.com reveals ...
(Date:6/24/2016)... ... ... crisis. Her son James, eight, was out of control. Prone to extreme mood shifts and ... him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife on ... say he was going to kill them. If we were driving on the freeway, ...
(Date:6/24/2016)... ... 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited to ... Recovery® program to drive cancer patients to and from their cancer treatments. Comfort ... quality of life and ongoing independence. Getting to and from medical treatments is ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SOUTH SAN FRANCISCO, Calif. , June 24, ... GBT ), a biopharmaceutical company developing novel ... with significant unmet needs, today announced the closing ... 6,400,000 shares of common stock, at the public ... the shares in the offering were offered by ...
(Date:6/24/2016)... 24, 2016 ... the addition of the " Global Markets for ... This report focuses on ... updated review, including its applications in various applications. The ... which includes three main industries: pharmaceutical and biotechnology, food ...
(Date:6/24/2016)... ALEXANDRIA, Va. , June 24, 2016 ... a set of recommendations that would allow ... information (HCEI) with entities that make formulary and coverage ... determine the "value" of new medicines. The ... that does not appear on the drug label, a ...
Breaking Medicine Technology: