Navigation Links
Stem cell transplant can grow new immune system in certain mice, Stanford researchers find
Date:11/22/2007

STANFORD, Calif. - Researchers at the Stanford University School of Medicine have taken a small but significant step, in mouse studies, toward the goal of transplanting adult stem cells to create a new immune system for people with autoimmune or genetic blood diseases.

The researchers found a way to transplant new blood-forming stem cells into the bone marrow of mice, effectively replacing their immune systems. Many aspects of the technique would need to be adapted before it can be tested in humans, said Irving Weissman, MD, a co-senior author of the study and director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine. The work was done on a particular group of mice that are a poor mimic for the human immune system. Still, Weissman suggested the remaining hurdles could eventually be overcome.

When those barriers are surmounted, the benefits are potentially big. The study will be published in the Nov. 23 issue of Science.

A person with an autoimmune disease such as multiple sclerosis has a defective immune system in which immune cells attack the person's own body. An immune system transplant, much like a liver or heart transplant, would give the person a new system that might not attack the body.

The way to get a new immune system is to transplant new blood-forming stem cells into the bone marrow, where they generate all the cells of the blood. But before transplanting new stem cells, the old ones first must be removed, which is currently done by intensive chemotherapy or radiation. Those processes eliminate the cells of the bone marrow, but also damage other tissue and can cause lasting effects including infertility, brain damage and an increased risk of cancer. A treatment for M.S. at the expense of brain function is hardly an ideal therapy.

Weissman and co-first author Deepta Bhattacharya, PhD, a postdoctoral scholar in Weissman's lab, thought one way around this problem would be to elimi
'/>"/>

Contact: Amy Adams
amyadams@stanford.edu
650-723-3900
Stanford University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Preclinical study suggests organ-transplant drug may aid in lupus fight
2. Study provides hope that some transplant patients could live free of antirejection drugs
3. Study provides hope that some transplant patients could live free of anti-rejection drugs
4. Advanced Age No Bar to Liver Transplant
5. Circulating fats kill transplanted pancreas cells, study shows
6. Sexual function affected by stem cell transplant according to long-term study
7. Dallas-Area Transplant Meeting Puts Spotlight on Key Issues
8. American Society of Transplantations Past President Testifies Before Congress at Forum on Organ Donation
9. Scientists Spot Key to Kidney Transplant Success
10. Fetal cell transplant could be a hidden link between childbirth and reduced risk of breast cancer
11. Patients over age 60 do well after liver transplantation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2015)... Illinois (PRWEB) April 24, 2015 Multi ... includes septic tank pumping ( http://www.zeitersseptics.com/multi-customer-discount.html ) of 1000-1500 ... to start the program. This does not include any ... applicable. Save $25-$65 per person. If someone is part ... or two tanks totaling approximately 2500 gallons or more, ...
(Date:4/24/2015)... 24, 2015 Carvers' goal is ... a successful biking day in Breck. , Conveniently ... minutes walking distance from Breckenridge, this family-owned place ... both Breckenridge bike rentals ( http://www.breckenridgeskishop.com/en/rent-equipment ) and ... extensive bike rentals in May 2015. With style ...
(Date:4/24/2015)... (PRWEB) April 24, 2015 The 1975 ... toured almost constantly across the globe to theaters, festivals and ... in Manchester, they’ve partnered with their label, Dirty Hit Records, ... Teaming up with the newly launched Cadence & Cause ... their debut LP on vinyl and a signed photo card. ...
(Date:4/24/2015)... Lowcostcarinsuranceprice.com has released a new blog post explaining ... senior citizens . , Senior citizens may be ... that they cannot find affordable coverage. By comparing online ... right coverage for their cars at the best prices. ... provides free leads from various agencies that are ...
(Date:4/24/2015)... 24, 2015 Integrative Therapeutics has ... pathways: immunity and cognition. , A unique combination ... set ProThrivers™ Wellness Flavonoid Complex apart from other ... of ingredients to support antioxidation versus the use ... curcumin, green tea extract, Resveratrol, Alpha-Glycosyl Isoquercitrin, and ...
Breaking Medicine News(10 mins):Health News:Zeiter's Septics Inc. Offers Multi Customer Septic Tank Cleaning Program in Cook, Putnam & Will Counties in May 2015 2Health News:Zeiter's Septics Inc. Offers Multi Customer Septic Tank Cleaning Program in Cook, Putnam & Will Counties in May 2015 3Health News:Carvers Breckenridge Bike Rentals Offers Demo Mountain, Tandem, Bike Path Cruiser & JR. Bikes in May 2015 2Health News:Internationally Recognized British Indie Rock Outfit The 1975 Partner with Cadence & Cause to Provide Clean Drinking Water to Those in Need 2Health News:Low Cost Auto Insurance Quotes for Senior Citizens 2Health News:Integrative Therapeutics Introduces Two ProThrivers™ Wellness Supplements with Specialty Ingredients from Kyowa Hakko USA 2Health News:Integrative Therapeutics Introduces Two ProThrivers™ Wellness Supplements with Specialty Ingredients from Kyowa Hakko USA 3Health News:Integrative Therapeutics Introduces Two ProThrivers™ Wellness Supplements with Specialty Ingredients from Kyowa Hakko USA 4
... he begins with the dramatic story of Mariana Bridi da ... January after amputation of both her hands and feet failed ... in allergy, pulmonary and critical care medicine, is part of ... with a high-tech approach to combat this deadly illness, which ...
... Radio" Host Interviews CPF Co-Founder, PF Advocate, and Top PF Researcher ... Coalition for Pulmonary Fibrosis (CPF) today announced its co-founder and other ... XM Satellite Radio Show "Doctor Radio" on Tuesday, June 16th from ... show can be heard via a free pass available on the ...
... heads West, driving home the importance of year-round parasite prevention ... Md., June 15 Temperate climates, high pet populations and ... States an ideal location for the upcoming second annual Companion ... July 11. , , During eight stops in four ...
... be safer for some older patients, researchers say, , ... colon cancer may be too risky for some elderly ... screening methods for colon cancer, a colonoscopy is considered ... also removes, cancerous and precancerous lesions. However, risks such ...
... Cardiovascular Institute open their doors to expose young women to ... , CHICAGO, June 15 Victoria Horsley is ... of high school. Though for her, learning the intricacies of ... (CSA) at Northwestern Memorial Hospital,s Bluhm Cardiovascular Institute will rank ...
... problems, new advisory says , MONDAY, June 15 ... are at greater risk of heart problems, wound ... to a Scientific Advisory from the American Heart ... other health-care providers underestimate the seriousness of the ...
Cached Medicine News:Health News:Vanderbilt researchers pioneer an advanced sepsis detection and management system 2Health News:Vanderbilt researchers pioneer an advanced sepsis detection and management system 3Health News:Vanderbilt researchers pioneer an advanced sepsis detection and management system 4Health News:Vanderbilt researchers pioneer an advanced sepsis detection and management system 5Health News:CPF, Pulmonary Fibrosis Experts Guests on Sirius and XM Satellite Radio Show June 16th 2Health News:Nonprofit Goes RVing to Promote Pet and Human Health 2Health News:Nonprofit Goes RVing to Promote Pet and Human Health 3Health News:Colonoscopy Risks Increase With Age and Illness 2Health News:Colonoscopy Risks Increase With Age and Illness 3Health News:Teens as Cardiologists in Training: Program Swaps Backpacks for Stethoscopes 2Health News:Teens as Cardiologists in Training: Program Swaps Backpacks for Stethoscopes 3Health News:Teens as Cardiologists in Training: Program Swaps Backpacks for Stethoscopes 4Health News:Heart Association Warns of Surgery Risks in Obese 2
(Date:4/23/2015)... NORTH CHICAGO, Ill. , April 24, 2015 /PRNewswire/ ... U.S. Food and Drug Administration (FDA) has accepted its ... the company,s, all-oral, interferon-free, two direct-acting antiviral treatment of ... is for the treatment of adults with chronic genotype ... AbbVie,s regimen is the first all-oral, interferon-free therapy being ...
(Date:4/23/2015)... Once again, BeaconMedaes is meeting healthcare facilities, ... safety. BeaconMedaes, priority is to partner with ... The next generation Zone Valve Box assembly strengthens ... mounted in the assembly, allowing for ease of sensor ... potentially releasing dust spores and other bacteria within the ...
(Date:4/23/2015)... April 23, 2015 Nektar Therapeutics (Nasdaq: NKTR ... ended March 31, 2015 on Thursday, April 30, 2015, after ... president and chief executive officer, will host a conference call ... (ET)/2:00 p.m. Pacific Time (PT). The press ... can be accessed through a link that is posted on ...
Breaking Medicine Technology:U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 2U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 3U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 4U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 5U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 6U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 7BeaconMedaes launches new Zone Valve Box Assembly 2Nektar to Announce Financial Results for the First Quarter 2015 on Thursday, April 30, 2015, After Close of U.S.-Based Financial Markets 2
... NEW YORK, April 7, 2011 Reportlinker.com announces ... in its catalogue: European ... http://www.reportlinker.com/p0470760/European-Markets-for-Interventional-Cardiology-Devices-2011-15-Countries.html ... cardiology devices were valued at over euro1.5 billion. ...
... Reportlinker.com announces that a new market research report ... Global: Pharmaceuticals Industry Guide ... Guide is an essential resource for top-level data ... includes detailed data on market size and segmentation, ...
Cached Medicine Technology:Reportlinker Adds European Markets for Interventional Cardiology Devices 2011 (15 Countries) 2Reportlinker Adds European Markets for Interventional Cardiology Devices 2011 (15 Countries) 3Reportlinker Adds European Markets for Interventional Cardiology Devices 2011 (15 Countries) 4Reportlinker Adds European Markets for Interventional Cardiology Devices 2011 (15 Countries) 5Reportlinker Adds European Markets for Interventional Cardiology Devices 2011 (15 Countries) 6Reportlinker Adds European Markets for Interventional Cardiology Devices 2011 (15 Countries) 7Reportlinker Adds European Markets for Interventional Cardiology Devices 2011 (15 Countries) 8Reportlinker Adds European Markets for Interventional Cardiology Devices 2011 (15 Countries) 9Reportlinker Adds European Markets for Interventional Cardiology Devices 2011 (15 Countries) 10Reportlinker Adds European Markets for Interventional Cardiology Devices 2011 (15 Countries) 11Reportlinker Adds European Markets for Interventional Cardiology Devices 2011 (15 Countries) 12Reportlinker Adds European Markets for Interventional Cardiology Devices 2011 (15 Countries) 13Reportlinker Adds European Markets for Interventional Cardiology Devices 2011 (15 Countries) 14Reportlinker Adds European Markets for Interventional Cardiology Devices 2011 (15 Countries) 15Reportlinker Adds European Markets for Interventional Cardiology Devices 2011 (15 Countries) 16Reportlinker Adds European Markets for Interventional Cardiology Devices 2011 (15 Countries) 17Reportlinker Adds European Markets for Interventional Cardiology Devices 2011 (15 Countries) 18Reportlinker Adds European Markets for Interventional Cardiology Devices 2011 (15 Countries) 19Reportlinker Adds European Markets for Interventional Cardiology Devices 2011 (15 Countries) 20Reportlinker Adds European Markets for Interventional Cardiology Devices 2011 (15 Countries) 21Reportlinker Adds Global: Pharmaceuticals Industry Guide 2Reportlinker Adds Global: Pharmaceuticals Industry Guide 3Reportlinker Adds Global: Pharmaceuticals Industry Guide 4Reportlinker Adds Global: Pharmaceuticals Industry Guide 5Reportlinker Adds Global: Pharmaceuticals Industry Guide 6Reportlinker Adds Global: Pharmaceuticals Industry Guide 7Reportlinker Adds Global: Pharmaceuticals Industry Guide 8
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: