Navigation Links
Stem cell 'sticky spots' recreated by scientists
Date:12/13/2012

Randomly distributed sticky spots which are integral to the development of stem cells by maximising adhesion and acting as internal scaffolding have been artificially recreated by experts from the University of Sheffield for the first time.

Using synthetic foam type materials to mimic the natural process known as the extracellular matrix or ECM scientists, from the University of Sheffield and University of California San Diego, created the random stickiness required for stem cells to properly adhere.

The findings will better inform researchers across the world of how to make their biomaterials appropriately sticky for stem cells to grow.

Previous attempts to recreate the process have managed only a uniform spread of sticky cells meaning there isn't the maximum hindering the stem cells maturation into tissue cells.

Professor Giuseppe Battaglia of the University's Department of Biomedical Science said: "We used two polymers, one that is sticky and one that is not, which separate from each other in solution. Just like with balsamic vinaigrette, we shook these two polymers up sufficiently to form randomly distributed nano-scopic patches of the sticky material the balsamic vinegar in a non-sticky material, just like the olive oil. To put it another way, these two materials phase separate within the foam to give you regions distinctly of one material or the other."

At the appropriate ratio of sticky and non-sticky polymer, the researchers found that it is possible to tune the size and distribution of the foam's adhesive regions: having less sticky polymer in the foam made its adhesive patches smaller and more dispersed, just like in the human body with natural ECM.

Professor Battaglia and Priyalakshmi Viswanathan, who performed most of the experimental work, added: "What was surprising to the team was that when we allowed stem cells to adhere to the foams, we found that random stickiness versus uniform stickiness was required for stem cells to properly adhere. We also found that this is likely necessary for stem cell development into mature tissue cells. In this sense, stem cells are like Goldilocks: the scaffold should not be too sticky or not sticky enough, it must be just right to maximize adhesion, and later, maturation into tissue cells."


'/>"/>

Contact: Paul Mannion
p.f.mannion@sheffield.ac.uk
01-142-229-851
University of Sheffield
Source:Eurekalert

Related medicine news :

1. Heart Test Spots Sudden Death Risk in Young Athletes
2. Study Spots Early Warning Signal for Sudden Cardiac Death
3. Technique spots disease using immune cell DNA
4. Diseases of aging map to a few hotspots on the human genome
5. Gene Mutation Changed Cheetahs Spots to Stripes
6. Scientists solving the mystery of human consciousness
7. Scientists uncover multiple faces of deadly breast cancer
8. Scientists identify major source of cells defense against oxidative stress
9. Scientists tailor cell surface targeting system to hit organelle ZIP codes
10. Scientists rewrite rulebook on breast cancer in landmark global study
11. Warwick scientists uncover how checkpoint proteins bind chromosomes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ... (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along ... updates for the primary prevention of cardiovascular diseases during the 15th Annual ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains ... possible to save lost souls in the Philippines. “The Journey: From the Mountains to ... dedicated teacher of the Bible. She has taught all ages and currently teaches a ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... products to meet the demand of today’s consumer and regulatory authorities worldwide. From ... probiotic experts and tested to meet the highest standard. , These products ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... Hair Restoration, has recently contributed a medical article to the newly revamped ... Dr. Mohebi’s article spotlights the hair transplant procedure known as Follicular Unit ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Mich. , Oct. 2, 2017 Diplomat ... 8th Day Software and Consulting, LLC , and ... 8th Day Software, based in Tennessee ... LLC. 8th Day expands EnvoyHealth,s service offerings for health ... development. "In an ...
(Date:10/2/2017)... Oct. 2, 2017  AllianceRx Walgreens Prime, the combined ... Walgreens and pharmacy benefit manager Prime Therapeutics LLC (Prime), ... which included the unveiling of new signage at its ... well as at a few other company-owned facilities across ... to patients, some of whom will begin to see ...
(Date:10/2/2017)... Denmark , Oct. 2, 2017 The Rebound ... in the struggle to reverse the tide of prescription drug ... for regulating their medicine intake and stepping down their dosage ... set to launch in December 2017; the first 100,000 people ... Learn more at http://www.rebound-solution.com/ ...
Breaking Medicine Technology: