Navigation Links
Stem cell 'sticky spots' recreated by scientists
Date:12/13/2012

Randomly distributed sticky spots which are integral to the development of stem cells by maximising adhesion and acting as internal scaffolding have been artificially recreated by experts from the University of Sheffield for the first time.

Using synthetic foam type materials to mimic the natural process known as the extracellular matrix or ECM scientists, from the University of Sheffield and University of California San Diego, created the random stickiness required for stem cells to properly adhere.

The findings will better inform researchers across the world of how to make their biomaterials appropriately sticky for stem cells to grow.

Previous attempts to recreate the process have managed only a uniform spread of sticky cells meaning there isn't the maximum hindering the stem cells maturation into tissue cells.

Professor Giuseppe Battaglia of the University's Department of Biomedical Science said: "We used two polymers, one that is sticky and one that is not, which separate from each other in solution. Just like with balsamic vinaigrette, we shook these two polymers up sufficiently to form randomly distributed nano-scopic patches of the sticky material the balsamic vinegar in a non-sticky material, just like the olive oil. To put it another way, these two materials phase separate within the foam to give you regions distinctly of one material or the other."

At the appropriate ratio of sticky and non-sticky polymer, the researchers found that it is possible to tune the size and distribution of the foam's adhesive regions: having less sticky polymer in the foam made its adhesive patches smaller and more dispersed, just like in the human body with natural ECM.

Professor Battaglia and Priyalakshmi Viswanathan, who performed most of the experimental work, added: "What was surprising to the team was that when we allowed stem cells to adhere to the foams, we found that random stickiness versus uniform stickiness was required for stem cells to properly adhere. We also found that this is likely necessary for stem cell development into mature tissue cells. In this sense, stem cells are like Goldilocks: the scaffold should not be too sticky or not sticky enough, it must be just right to maximize adhesion, and later, maturation into tissue cells."


'/>"/>

Contact: Paul Mannion
p.f.mannion@sheffield.ac.uk
01-142-229-851
University of Sheffield
Source:Eurekalert

Related medicine news :

1. Heart Test Spots Sudden Death Risk in Young Athletes
2. Study Spots Early Warning Signal for Sudden Cardiac Death
3. Technique spots disease using immune cell DNA
4. Diseases of aging map to a few hotspots on the human genome
5. Gene Mutation Changed Cheetahs Spots to Stripes
6. Scientists solving the mystery of human consciousness
7. Scientists uncover multiple faces of deadly breast cancer
8. Scientists identify major source of cells defense against oxidative stress
9. Scientists tailor cell surface targeting system to hit organelle ZIP codes
10. Scientists rewrite rulebook on breast cancer in landmark global study
11. Warwick scientists uncover how checkpoint proteins bind chromosomes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... ... Digital Scientists, a software innovation lab specializing in web design and app ... location. The lab has set up shop at the renowned NEXT Innovation Center, ... clients for years from our office here in Atlanta,” explains Digital Scientists’ CEO, Bob ...
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... According to ... score is invalid because it does not obey the rules Congress has directed the ... equivalent jobs, which the GOP reform would restore. Yet, it estimates a reduction in ...
(Date:3/24/2017)... ... ... The iaedp Foundation, the premier provider of educational programs and training standards for ... spectrum of disordered eating, announced today that the 2017 Symposium set a new attendance ... several countries converged on the Green Valley Resort in Las Vegas. , “We ...
(Date:3/24/2017)... ... 24, 2017 , ... Shamanic healer and teacher Anahata Ananda ... Spiritual Awakening, proudly presents her Sacred Peru retreat with world famous shaman ... journey during the Summer Solstice will also be her final international retreat, Anahata ...
(Date:3/24/2017)... ... March 24, 2017 , ... As the standards ... a communications platform that positions them as the go-to thought leader in all ... online publication as an always-on, always-fresh news, views and advocacy engine, called ONS ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... 23, 2017 Research and Markets has announced ... - Industry Forecast to 2025" report to their offering. ... The Global Cryostat ... over the next decade to reach approximately $3.5 billion by 2025. ... for all the given segments on global as well as regional ...
(Date:3/23/2017)... LONDON , March 23, 2017 ... comprehensive research report created through extensive primary research ... research, the report aims to present the analysis ... basis of Procedure (Replacement and Repair); Replacement Procedure ... (TAVR)), Repair By Technique (Surgical Devices, Balloon Valvuloplasty, ...
(Date:3/23/2017)... , March 23, 2017   BioSpace , the ... has partnered with Indiana Biosciences Research Institute ... organizations and educational institutions to bring the state,s life ... BioIndiana Hotbed map, an artistic representation of the region,s ... presented to Vice President Mike Pence , a ...
Breaking Medicine Technology: