Navigation Links
Stem cell regeneration repairs congenital heart defect
Date:9/11/2008

ROCHESTER, Minn. -- Mayo Clinic investigators have demonstrated that stem cells can be used to regenerate heart tissue to treat dilated cardiomyopathy, a congenital defect. Publication of the discovery was expedited by the editors of Stem Cells and appeared online in the "express" section of the journal's Web site at http://stemcells.alphamedpress.org/.

The study expands on the use of embryonic stem cells to regenerate tissue and repair damage after heart attacks and demonstrates that stem cells also can repair the inherited causes of heart failure.

"We've shown in this transgenic animal model that embryonic stem cells may offer an option in repairing genetic heart problems," says Satsuki Yamada, M.D., Ph.D., cardiovascular researcher and first author of the study. "Close evaluation of genetic variations among individuals to identify optimal disease targets and customize stem cells for therapy opens a new era of personalized regenerative medicine," adds Andre Terzic, M.D., Ph.D., Mayo Clinic cardiologist and senior author and principal investigator.

How They Did It

The team reproduced prominent features of human malignant heart failure in a series of genetically altered mice. Specifically, the "knockout" of a critical heart-protective protein known as the KATP channel compromised heart contractions and caused ventricular dilation or heart enlargement. The condition, including poor survival, is typical of patients with heritable dilated cardiomyopathy.

Researchers transplanted 200,000 embryonic stem cells into the wall of the left ventricle of the knockout mice. After one month the treatment improved heart performance, synchronized electrical impulses and stopped heart deterioration, ultimately saving the animal's life. Stem cells had grafted into the heart and formed new cardiac tissue. Additionally, the stem cell transplantation restarted cell cycle activity and halved the fibrosis that had been developing after the initial damage. Stem cell therapy also increased stamina and removed fluid buildup in the body, so characteristic in heart failure.

The researchers say their findings show that stem cells can achieve functional repair in non-ischemic (cases other than blood-flow blockages) genetic cardiomyopathy. Further testing is underway.


'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. Sound Pharmaceuticals Receives Additional DoD Funding for Its Hearing Regeneration Product
2. Novel hydrogel systems for dentin regeneration
3. George to receive Pulp Biology and Regeneration Award
4. Saving teeth by using periodontal ligament regeneration
5. Cartilage regeneration 20,000 Leagues Under the Sea
6. Protein key to neuro-regeneration
7. An international first at the CHUM - Promising treatment in regeneration of the myocardium through the use of stem cells
8. Transplanted Bone Marrow Cells Aid Nerve Regeneration
9. Neurotransmitters in biopolymers stimulate nerve regeneration
10. Bone marrow cell transplants help nerve regeneration
11. Ellex Announces New Retina Regeneration Therapy to be Presented at the AAO
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... Using the power of the internet, ... online checklist. Over a period of just 24 months, thousands of individuals interested in ... checklist called T.A.D. , “The internet is not getting quieter. In fact it’s becoming ...
(Date:2/22/2017)... ... 22, 2017 , ... Bellus Medical, a leader in medical ... delivery of Platelet Rich Plasma (PRP). PRP systems are used by physicians in ... synthesis and provide a faster and more efficient healing process. There are many ...
(Date:2/22/2017)... ... February 22, 2017 , ... Super-Sod will attend the Athens ... in Athens, Georgia. , A shift from Super-Sod’s simple Athens Home Show booth of ... the booth, grass seed plant manager Chris Roquemore constructed furniture from recycled pallet wood ...
(Date:2/22/2017)... ... February 22, 2017 , ... In ... many different solutions on the market, it is easy to start feeling frustrated ... Locksmith offers a complimentary security consultation. , Home Security Hardware Choices, There ...
(Date:2/21/2017)... , ... February 22, 2017 , ... Author Michèle Wolff ... valuable for every household and family to know all about it for optimal health. ... with the release of “ Detox, Digestive and Wellness Solutions ” (published by Balboa ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... , Feb. 22, 2017   Protein Sciences Corporation ... Flublok® Influenza Vaccine , announced today that they ... Influenza Vaccine Introduction (PIVI) and the Mongolian Ministry of ... of the flu.  The doses of Flublok have been ... Mongolia for health care workers, pregnant women, ...
(Date:2/22/2017)... 22, 2017 The Senior Care Pharmacy Coalition ... and House of Representatives that will curtail the ability ... -- from extracting retroactive direct and indirect remuneration (DIR) ... pharmacies and the Medicare program. S. 413, ... and Jon Tester (D-MT), and House companion ...
(Date:2/22/2017)... , Feb 22, 2017 Research ... Temperature Monitoring Devices Market (Thermometers - Digital, Infrared, Mercury; Trend Indicator):Analysis ... ... Monitoring Devices Market is forecasted to grow at a CAGR of ... the rising prevalence of infectious diseases along with surging demand of ...
Breaking Medicine Technology: