Navigation Links
Stem cell model offers clues to cause of inherited ALS
Date:6/21/2011

An international team of scientists led by researchers at the University of California, San Diego School of Medicine have used induced pluripotent stem cells (iPSCs) derived from patients with amyotrophic lateral sclerosis (ALS) to reveal for the first time how reduced levels of a specific protein may play a central role in causing at least one inherited form of the disease.

The work, published in the June 2011 online issue of the journal Human Molecular Genetics, could help scientists overcome a major hurdle in the study and treatment of ALS, an incurable neuromuscular disorder also known as Lou Gehrig's disease. ALS is universally fatal, with a median age of onset of 55 years and survival of two to five years after symptoms appear. Past research efforts have long been stymied by difficulties in translating successful drug tests in animal models of ALS to humans.

"There is an urgent need for ALS human models that can be translated into clinical trials to verify therapeutic targets in the human genetic background," said Alysson R. Muotri, PhD, assistant professor in the UCSD Departments of Pediatrics and Cellular and Molecular Medicine, and one of the study's senior authors. "Rodents have been used in the past and still have a critical impact in unveiling the complexity of ALS, but the vast majority of drugs that have demonstrated efficacy in rodent models have not done the same in preclinical and clinical human trials."

In the new work, Muotri and colleagues turned to iPSCs derived from the skin cells of patients with a familial form of ALS called ALS8 to create motor neurons that provided a novel in vitro model of the disease. iPSCs from ALS patients have been described before, but finding cellular and molecular phenotypes has proved to be a continuing challenge. The use of a familial form of ALS offered an advantage since the mutated gene could be tracked during motor neuron differentiation.

"We don't know what
'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. New book shines light on French versus British models of humanitarian aid
2. Teens look to parents more than friends for sexual role models
3. Internal bleeding higher with popular heart device than earlier model
4. Scientists create humanized mouse model for hepatitis C
5. Using simulation to model the implementation of electronic health records
6. Breaking the fracture cycle through effective and coordinated models of care
7. Pitt researchers build a better mouse model to study depression
8. New model taps tiny, common tropical fish for large-scale drug screening to combat Cushing disease
9. Model developed to improve combination vaccine accessibility worldwide
10. INFORMS health care conference highlights increased role of math modeling in health systems
11. Virtual lung models set to personalize asthma and COPD treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stem cell model offers clues to cause of inherited ALS
(Date:9/2/2015)... ... September 02, 2015 , ... ... endpoint data collection, cloud analytics and workflow solutions today announced the September ... pharmaceutical researchers to participate in interactive programs in which ERT scientists and ...
(Date:9/2/2015)... ... September 02, 2015 , ... RxNT , ... launch of its enhanced, cloud-based mobile ePrescribing application. The release of this enhanced ... prescriber usability. A leader in health technology, RxNT was one of the first ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... Affairs Officer following the departure of Kristen Dietz, former Chief Operations Officer. ... released the following statement welcoming Mr. Salot: “ Stanley H. Salot Jr , ...
(Date:9/2/2015)... ... September 02, 2015 , ... Splashtop Inc., the worldwide leader ... screen mirroring and extending product line -- Splashtop Wired XDisplay . ... WIFI setting, the new Splashtop Wired XDisplay delivers enhanced performance and reliability for ...
(Date:9/2/2015)... ... September 02, 2015 , ... Care Providers and their ... documents that include EOBs, payments, and payment related documents. AD-EOB A/R helps them ... reconcile their billing, with one efficient process and interface,“ stated Rich Caproni, AliusDoc’s ...
Breaking Medicine News(10 mins):Health News:ERT Announces Web Seminar Series on Optimizing Trial Data Collection & Gaining Real-Time Data Insights 2Health News:ERT Announces Web Seminar Series on Optimizing Trial Data Collection & Gaining Real-Time Data Insights 3Health News:RxNT Releases Enhanced ePrescribing iPhone App to Improve Prescriber Usability 2Health News:Healtec® Announces Executive Leadership Change 2Health News:Splashtop Launches Wired XDisplay, the Fastest Screen Sharing Solution for Extending and Mirroring Your Computer Screen to Mobile Devices 2Health News:Splashtop Launches Wired XDisplay, the Fastest Screen Sharing Solution for Extending and Mirroring Your Computer Screen to Mobile Devices 3Health News:AliusDoc Launches Enhanced AD-EOB A/R Data Capture Solution to Streamline Processing of Payment-Related Documents Together with EOBs 2
... groups were thought to be rare, but recent studies ... the thin beauty ideal. As a result, experts expect ... ethnic groups. It is also suspected that eating disorders ... boys. Although research has shown that eating disorders ...
... of the Charmin Restrooms to ... Times Square This Holiday Season, NEW YORK, Nov. ... free, fully-staffed public restrooms,in New York City as the Charmin(R) Restrooms ... Shannon will inaugurate the stalls,with the ceremonial "first flush" and ribbon ...
... Family Caregiver,s Month; Announces Availability ... More than 34 Million Caregivers, PALO ALTO, Calif., Nov. ... proud to support the more than 34 million,Americans caring for ... availability of its website. Designed to give caregivers the ...
... Flow Cytometry Portfolio Targeted at Fast Growing ... ... Nov. 19, Beckman Coulter, Inc. (NYSE: BEC ), a leading,developer ... A/S, a world leader in cancer diagnostics,announced today that Beckman Coulter ...
... REDWOOD CITY, Calif., Nov. 19 People grow ... is no different. SleepQuest, the leader in,at-home diagnostic ... growing pains which accompany rapid growth by moving ... INC. Magazine,s 5000 Fastest Growing Private,Companies in America, ...
... GNC is joining St. Jude Children,s,Research Hospital as ... is the fourth year for the national campaign and ... in the effort. Thanks and Giving was created ... Thomas and her siblings, Terre and Tony,Thomas, the children ...
Cached Medicine News:Health News:Eating disorders in adolescents 2Health News:Eating disorders in adolescents 3Health News:Video: Charmin's Gift That Keeps on Giving! 2Health News:Resource to Help Care for Aging Parents Now Available Nationwide 2Health News:Resource to Help Care for Aging Parents Now Available Nationwide 3Health News:Beckman Coulter to Acquire Flow Cytometry Instrumentation Business From Dako 2Health News:Beckman Coulter to Acquire Flow Cytometry Instrumentation Business From Dako 3Health News:SleepQuest Continues Growth, Moves Headquarters 2Health News:GNC Joins St. Jude Children's Research Hospital(R) to Kick Off Fourth Annual Thanks And Giving(R) Campaign, Asking America to Help Save Children's Lives While Shopping for the Holidays 2Health News:GNC Joins St. Jude Children's Research Hospital(R) to Kick Off Fourth Annual Thanks And Giving(R) Campaign, Asking America to Help Save Children's Lives While Shopping for the Holidays 3
(Date:9/2/2015)... , Sept. 2, 2015 Boston Scientific Corporation ... 2015 Morgan Stanley Global Healthcare Conference on September 17, in ... Mike Mahoney , chief executive officer, and Dan Brennan ... in a 30-minute question and answer session regarding the company ... A live webcast of the question and answer ...
(Date:9/2/2015)... , Sept. 2, 2015 China Biologic ... "Company"), a leading fully integrated plasma-based biopharmaceutical company ... that the Company,s subsidiary Guizhou Taibang Biological Products ... collaboration agreement (the "Agreement") with Xinjiang Deyuan Bioengineering ... The Agreement allows Guizhou Taibang to source no ...
(Date:9/2/2015)... PAUL, Minn. , Sept. 2, 2015  MGC ... today scheduled a conference call to discuss its financial ... July 31, 2015. The call will be at 4:30 ... will report financial results for the third quarter of ... 10, 2015. Participants can dial (877) ...
Breaking Medicine Technology:Boston Scientific To Participate In 2015 Morgan Stanley Global Healthcare Conference 2China Biologic Enters into Strategic Collaboration Agreement to Source Raw Materials 2China Biologic Enters into Strategic Collaboration Agreement to Source Raw Materials 3China Biologic Enters into Strategic Collaboration Agreement to Source Raw Materials 4China Biologic Enters into Strategic Collaboration Agreement to Source Raw Materials 5MGC Diagnostics Corporation to Report Third Quarter Fiscal 2015 Financial Results on Thursday, September 10, 2015 2
... , OXFORD, England ... ,EUSA Pharma, a transatlantic specialty pharmaceutical company focused ... it has granted,the Japanese development and commercialization rights to ... agreement represents,the first product partnership EUSA has established in ...
... ProUroCare Medical, Inc. (OTC Bulletin Board: PUMD) today announced ... certain outstanding warrants to provide additional consideration for the exercise ... are 1,752,760 publicly traded warrants and 2,752,947 unregistered warrants to ... 2009 and will expire on January 7, 2014 ...
Cached Medicine Technology:EUSA Pharma Grants Japanese Rights to Erwinase(R) Oncology Therapy to Ohara Pharmaceutical 2EUSA Pharma Grants Japanese Rights to Erwinase(R) Oncology Therapy to Ohara Pharmaceutical 3ProUroCare Medical Announces Offering of Replacement Warrants in Exchange for Early Exercise of Outstanding Warrants 2ProUroCare Medical Announces Offering of Replacement Warrants in Exchange for Early Exercise of Outstanding Warrants 3
Stryker Endoscopy offers a superior selection of probes and tips that interface with our suction and irrigation system....
The new PERIMOUNT Magna heart valve (bioprosthesis), with its true supra-annular design, offers optimal hemodynamics and flow characteristics for treatment of aortic heart valve disease....
... revolutionary flexibility to floor-mounted X-ray systems. ... move the C-arm around the exam ... optimal angle for cardiac and general ... cardiac flat panel detector that delivers ...
... pH.p Capsule passes through the GI tract, it ... frequencies to the SmartPill Data Receiver, a small, ... the patient (supported by either a belt or ... and pH measurement data, and elapsed and real ...
Medicine Products: