Navigation Links
Stem cell mobilization therapy found to be safe for bone marrow donors
Date:8/11/2011

(WASHINGTON, August 11, 2011) According to a study published in Blood, the Journal of the American Society of Hematology (ASH), researchers have reported that administration of granulocyte colony-stimulating factor (G-CSF), a drug that releases stem cells from the bone marrow into the blood, is unlikely to put healthy stem cell donors at risk for later development of abnormalities involving loss or gains of chromosomes that have been linked to hematologic disorders such as myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML).

G-CSF therapy is given to healthy stem cell donors in order to move the donor's stem cells out of the bone marrow and into the blood stream, a process called mobilization. Once in the blood, large doses of stem cells can be collected safely and without surgery via a process called apheresis, avoiding bone marrow harvest in the operating room. Research has shown that the large doses of mobilized stem cells (called peripheral blood stem cells or PBSCs) can repopulate the bone marrow and create new blood cells faster than stem cells collected directly from the bone marrow, and a number of long-term follow-up studies have demonstrated that healthy donors are not at an increased risk of developing leukemia or other cancers following PBSC donation.

"In recent years, PBSCs have become the dominant source of stem cells for stem cell transplants and the number of transplants performed with PBSCs that have been mobilized with G-CSF has substantially increased. However, the potential for the therapy to cause DNA damage, mutations, or cancer had been suggested in a smaller and less comprehensive prior study, raising a serious concern within the transplant community and making a definitive study very important. Our study aimed at investigating potential effects of G-CSF on chromosomes in healthy donors," said Betsy Hirsch, PhD, first author of the study and Associate Professor in the Department of Laboratory Medicine and Pathology at the University of Minnesota Medical School.

In order to explore whether G-CSF therapy is indeed a potential cause of chromosome loss or gain in donors, a research team from the University of Minnesota Medical School conducted a study to determine whether there was any risk with short-term, low-dose usage of G-CSF on healthy PBSC donors. The study evaluated blood samples taken from 22 PBSC donors who had received G-CSF and 22 controls with no history of cancer or prior exposure to the therapy over a 12 month period.

Using fluorescence in situ hybridization (FISH), a technique that can detect specific targeted regions of DNA in an individual's cells to identify chromosomal abnormalities, the researchers evaluated the white blood cells of the study subjects for aneuploidy, a condition in which there is an abnormal number of chromosomes. Loss and gain of chromosomes represent one form of chromosome instability that is frequently a step in the development of cancer. Specifically, the researchers focused on chromosome 7 and a series of other chromosomal regions well documented to be associated with MDS and AML. The researchers also evaluated the cells to determine if both copies of a given chromosome replicated in synchrony or asynchronously, as asynchronous replication can also signal genomic instability and a higher risk of chromosomal abnormalities.

"Contrary to the previously published data, our study concludes that G-CSF stimulation does not result in replication asynchrony or induce the atypical levels of abnormality for chromosome 7 or other chromosomes that have been associated with MDS and AML, and we expect that these results can be generalized to all chromosomes," said Dr. Hirsch.

Jeffrey McCullough, MD, senior study author and Professor in the Department of Laboratory Medicine and Pathology at the University of Minnesota Medical School, added, "Furthermore, our data support the conclusion that G-CSF does not induce chromosomal instability through the PBSC mobilization process and remains a safe therapy for healthy stem cell donors."


'/>"/>

Contact: Lindsey Love
webmaster@hematology.org
202-552-4925
American Society of Hematology
Source:Eurekalert

Related medicine news :

1. CPAP Therapy Most Effective for Sleep Apnea, Experts Say
2. Hormone reduces risk of heart failure from chemotherapy
3. Stem Cell Therapy Holds Promise for Kidney Disease
4. Aggressive drug therapy aids superbug evolution
5. Combination of existing safety checks could greatly reduce radiotherapy errors
6. New therapy may help people with unexplained symptoms of pain, weakness and fatigue
7. Scientists developing new therapy for HER2-positive breast cancer
8. Hormone therapy may be hazardous for men with heart conditions
9. Penn receives $10 million to create center for orphan disease research and therapy
10. BUSM: Testosterone deficiency and replacement therapy in men
11. International AIDS Society to launch Virtual Media Centre in July to support opioid substitution therapy in Eastern Europe and Central Asia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... Nevada (PRWEB) , ... October 13, 2017 , ... ... Hemp CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil ... required and providing a CBD form that can be easily incorporated into liquid products, ...
(Date:10/13/2017)... ... ... Apple Rehab Shelton Lakes , which specializes in the delivery of sub-acute ... of a disaster drill on October 3rd. , Apple Rehab participated with the Shelton ... well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). The LTC-MAP ...
(Date:10/13/2017)... ... 2017 , ... Ellevate Network, the leading network for professional women, brought together ... equality at their inaugural Summit in New York City in June. The event was ... of over 3 million. To watch the Mobilize Women video, click here . ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob ... sciatica in a new episode of "Success Files," which is an award-winning educational ... and investigates each subject in-depth with passion and integrity. , Sciatica occurs when ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “America On The ... identity. “America On The Brink” is the creation of published author, William Nowers. ... great-grandchildren. As a WWII veteran, he spent thirty years in the Navy. ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... , Sept. 25, 2017   Montrium , ... File solutions, today—from the IQPC Trial Master Files ... , NL)—announced that EastHORN Clinical Services has selected ... programs and TMF management. EastHORN, a leading European ... platform to increase transparency to enable greater collaboration ...
(Date:9/22/2017)... 2017 AVACEN Medical (AVACEN) announced that its ... helping those with the widespread pain associated with fibromyalgia ... in Essex, England commented, "I ... experiencing no sleep at all, tremendous pain, with every ... recommend [the AVACEN 100] enough, how this has and ...
(Date:9/18/2017)... , Sept. 18, 2017 ... fields of bioinformatics and immune engineering, today ... protective avian influenza A (H7N9) vaccine. ... related to seasonal influenza and presents a ... on prior exposure to be effective. Using ...
Breaking Medicine Technology: