Navigation Links
Stem cell breakthrough: Bone marrow cells are the answer
Date:1/28/2010

Using cells from mice, scientists from Iowa and Iran have discovered a new strategy for making embryonic stem cell transplants less likely to be rejected by a recipient's immune system. This strategy, described in a new research report appearing in the February 2010 print issue of The FASEB Journal (http://www.fasebj.org), involves fusing bone marrow cells to embryonic stem cells. Once fused, the hybrid cells have DNA from both the donor and recipient, raising hopes that immune rejection of embryonic stem cell therapies can be avoided without drugs.

"Our study shows that transplanted bone marrow cells fuse not only with bone marrow cells of the recipient, but with non-hematopoietic cells, suggesting that if we can understand the process of cell fusion better, we may be able to target certain organ injuries with the patient's own bone marrow cells and repair the tissues," said Nicholas Zavazava, M.D., Ph.D., a University of Iowa researcher involved in the work.

Although the study holds great promise for future embryonic stem cell therapies, the results may be even more far reaching. Zavazava and colleagues used two different mouse strains, one as the donor and the other as the recipient. When bone marrow cells were engrafted into the recipient, they tested for the presence of both donor and recipient cells and found three different types of cells: donor cells, recipient cells, and fused cells that had DNA from the donor and recipient. They then discovered that these cells could fuse with many different types of cells in addition to embryonic stem cells, including those from the liver, kidney, heart, and gut. Although more work is necessary to determine the exact clinical outcomes, the discovery raises the possibility that bone marrow cells could be fused to transplant organs to reduce the likelihood of rejection. They could also be fused to failing organs to support regeneration.

"Unlike machines where the same part can be used for several different makes and models, each of us is custom built, and our immune system does the quality control," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "As a result, human replacement parts, or organs, need to closely match the tissue of the recipient. This research uses bone marrow cells to fuse with a patient tissues so that nothing transplanted is rejected by our immune systems, and brings universal graft survival closer to reality."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. Medical Breakthrough: Drug Free Strategy Shows Promise for Reversing or Halting Osteoporosis for Michigan Men and Women
2. Hypnotherapy Breakthrough: Renowned Smoking Cessation Specialist Helps To Stop Smoking In One Session
3. Oosight Imaging System Enables a Breakthrough: The Viable Transfer of Genetic Material for Stem Cell Nuclear Reprogramming in Primates
4. Mayo Clinic Proceedings: Researchers find evidence of survival gains in bone marrow disease
5. Bone Marrow Transplants May Cure Sickle Cell in Adults
6. Missing Gene Tied to Bone Marrow Transplant Problems
7. High-sensitivity bone marrow aspiration technology enhances leukemia cell detection
8. Van Andel Institute researchers find gene that could lead to new therapies for bone marrow disease
9. Save a Life: Join the Kiel Mortgage Marrow-thon on September 23
10. Help Save a Life - Bone Marrow Donor Registry Drive Sept. 2 at the Karmanos Cancer Center
11. ThermoGenesis Announces Launch of Res-Q System; New Device Expands Companys Presence in Bone Marrow Sector
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... ... , ... A July 5th article on Reuters Health News discusses ... a body contouring procedure reported experiencing a better quality of life, compared to other ... both types of procedures, notes that this report jibes with what they regularly hear ...
(Date:7/18/2017)... ... July 18, 2017 , ... Cognition ... just announced two more sessions of its “From the Helm” Webinar Series. ... Led by David Cronin, Cognition’s CEO, the half-hour public webinars will take an ...
(Date:7/18/2017)... , ... July 18, 2017 , ... An inventor from ... quick and easy way to clean, scrub and moisturize the back and other hard-to-reach ... had surgery that limited movement in my upper body, particularly my shoulders. I found ...
(Date:7/17/2017)... ... July 18, 2017 , ... ... ps pulse width and a new published paper entitled ‘Pattern analysis of ... phantom’ featured in Nature’s specialty journal Scientific Reports May 08, 2017. The ...
(Date:7/17/2017)... ... July 17, 2017 , ... Western University ... the Chronicle of Higher Education for the sixth consecutive year, and also made ... in Pomona, California and Lebanon, Oregon, was recognized in seven categories: Collaborative Governance, ...
Breaking Medicine News(10 mins):
(Date:7/5/2017)... MANCHESTER, England , July 5, 2017 ... the perfect answer as physics and manufacturing combine to progress ... the thyroid, existing SPECT systems are unable to accurately quantify ... consequence, only limited information regarding the success of this radiotherapy ... ...
(Date:6/30/2017)... Md. , June 30, 2017 In ... since the start of May, at least ten diagnostic ... include private investments, public offerings and a loan facility.  ... million to almost $80 million.  Kalorama Information provides a ... of its Diagnostics Knowledge Center. ...
(Date:6/20/2017)... ROTTERDAM, Netherlands and LAGUNA HILLS, ... announced the presentation of new data that validate the ... to risk stratify patients with multiple myeloma (MM). In ... of the European Hematology Association (EHA) in ... prognostic value of MMprofiler for identifying high-risk elderly patients. ...
Breaking Medicine Technology: