Navigation Links
Stem cell breakthrough: Bone marrow cells are the answer
Date:1/28/2010

Using cells from mice, scientists from Iowa and Iran have discovered a new strategy for making embryonic stem cell transplants less likely to be rejected by a recipient's immune system. This strategy, described in a new research report appearing in the February 2010 print issue of The FASEB Journal (http://www.fasebj.org), involves fusing bone marrow cells to embryonic stem cells. Once fused, the hybrid cells have DNA from both the donor and recipient, raising hopes that immune rejection of embryonic stem cell therapies can be avoided without drugs.

"Our study shows that transplanted bone marrow cells fuse not only with bone marrow cells of the recipient, but with non-hematopoietic cells, suggesting that if we can understand the process of cell fusion better, we may be able to target certain organ injuries with the patient's own bone marrow cells and repair the tissues," said Nicholas Zavazava, M.D., Ph.D., a University of Iowa researcher involved in the work.

Although the study holds great promise for future embryonic stem cell therapies, the results may be even more far reaching. Zavazava and colleagues used two different mouse strains, one as the donor and the other as the recipient. When bone marrow cells were engrafted into the recipient, they tested for the presence of both donor and recipient cells and found three different types of cells: donor cells, recipient cells, and fused cells that had DNA from the donor and recipient. They then discovered that these cells could fuse with many different types of cells in addition to embryonic stem cells, including those from the liver, kidney, heart, and gut. Although more work is necessary to determine the exact clinical outcomes, the discovery raises the possibility that bone marrow cells could be fused to transplant organs to reduce the likelihood of rejection. They could also be fused to failing organs to support regeneration.

"Unlike machines where the same part can be used for several different makes and models, each of us is custom built, and our immune system does the quality control," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "As a result, human replacement parts, or organs, need to closely match the tissue of the recipient. This research uses bone marrow cells to fuse with a patient tissues so that nothing transplanted is rejected by our immune systems, and brings universal graft survival closer to reality."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. Medical Breakthrough: Drug Free Strategy Shows Promise for Reversing or Halting Osteoporosis for Michigan Men and Women
2. Hypnotherapy Breakthrough: Renowned Smoking Cessation Specialist Helps To Stop Smoking In One Session
3. Oosight Imaging System Enables a Breakthrough: The Viable Transfer of Genetic Material for Stem Cell Nuclear Reprogramming in Primates
4. Mayo Clinic Proceedings: Researchers find evidence of survival gains in bone marrow disease
5. Bone Marrow Transplants May Cure Sickle Cell in Adults
6. Missing Gene Tied to Bone Marrow Transplant Problems
7. High-sensitivity bone marrow aspiration technology enhances leukemia cell detection
8. Van Andel Institute researchers find gene that could lead to new therapies for bone marrow disease
9. Save a Life: Join the Kiel Mortgage Marrow-thon on September 23
10. Help Save a Life - Bone Marrow Donor Registry Drive Sept. 2 at the Karmanos Cancer Center
11. ThermoGenesis Announces Launch of Res-Q System; New Device Expands Companys Presence in Bone Marrow Sector
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... March 24, 2017 , ... ... (ONS) wanted to create a communications platform that positions them as the go-to ... and ONS reinvented their online publication as an always-on, always-fresh news, views and ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... the Advanced ERISA Benefit Claims Litigation seminar in Chicago, Illinois. She will ... The majority of cases litigated under ERISA involve claims for long-term disability benefits. ...
(Date:3/24/2017)... ... ... Viewers who like to educate themselves on current issues and who enjoy gaining ... issues tend to appreciate and love the "Informed" series, hosted by Rob Lowe. ... causes around the world. , Running for charity has become a multi-million ...
(Date:3/24/2017)... Texas (PRWEB) , ... March 24, 2017 , ... ... 2017 the year of enhancements, upgrading their training and leads programs. , In ... University. Reserved for elite sales agents, Performance Partners is designed to teach how ...
(Date:3/24/2017)... ... , ... “Finding Christ Through Social Media: Year One #A365DayJourney ... writer’s path toward true communion with God. “Finding Christ Through Social Media: Year ... of published author Lea Michelle Johnson, a follower of Christ, wife and mother ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... , Mar 24, 2017 Research and Markets ... Discovery and Diagnostics, 2017 - 2035" report to their offering. ... The Deep Learning: ... and future outlook of the growing market of deep learning solutions ... deep learning algorithms have emerged as a novel solution to generate ...
(Date:3/24/2017)... , Mar 24, 2017 Research and Markets ... Global Strategic Business Report" report to their offering. ... The report provides separate comprehensive analytics for ... Europe , Asia-Pacific , ... are provided for the period 2015 through 2022. Also, a six-year historic ...
(Date:3/24/2017)... 2017  Mirabilis Medical, a Seattle ... non-invasive surgery, announced today CE Mark authorization for ... uterine fibroids throughout the European Union.  The company ... the US Food and Drug Administration to begin ... the United States.  The Mirabilis System combines high-speed ...
Breaking Medicine Technology: