Navigation Links
Stem Cells Used for 'Biological Pacemaker'

In experiments with mice, researchers corrected electrical problems of the heart

WEDNESDAY, July 22 (HealthDay News) -- Stem cells from a type of human fat tissue may one day be able to reverse the electrical problems in the heart that pacemakers now correct, Japanese scientists report.

Researchers grew "beating" cells with properties similar to the heart's conductive tissue from stem cells taken from the brown fat tissue of mice. They then injected them into rodents with reduced heart rates caused by electrical signaling problems known as atrioventricular (AV) block.

After a week, the AV block was completely reversed or partially reversed in half of the test mice, according to the report scheduled to be presented Wednesday at the American Heart Association's Basic Cardiovascular Sciences Conference in Dallas. No change was observed in the control mice, they said.

The beating cells, which researchers colored green so they would be easy to see, were found to have attached near the section of the heart that manages its electrical conduction systems.

"Electronic pacemakers are often used as palliative therapy (helpful but not curative treatment) for people who have conduction problems with the electrical signals that govern the heart beat. However, that therapy has several shortcomings, including possible malfunction and the need for repeated replacement of the device's power packs and electrodes," study lead author Dr. Toshinao Takahashi, a research fellow at Chiba University Graduate School of Medicine in Chiba, Japan, said in an American Heart Association news release. "Cell therapy could overcome those problems and provide a possible cure for conductive disease. Our goal is to create a biological pacemaker."

Brown fat tissue is a source of mesenchymal stem cells, which previous studies have shown can develop into many different types of cells, such as bone, neuron, muscle, liver and fat cells. After isolating these cells in a laboratory, the Japanese team managed to grow groups of spontaneously beating cells. One tube-like group of cells resembled the heart's fine muscle fiber, while all contained two proteins, chemical markers and other similarities to the heart's own pacemaker-like cells.

"Our findings suggest that brown-fat-derived mesenchymal stem cells…may become a useful cell source for antiarrhythmic therapy," Takahashi said.

More information

The National Heart, Lung, and Blood Institute has more about pacemakers.

-- Kevin McKeever

SOURCE: American Heart Association, news release, July 22, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
2. Brain cells work differently than previously thought
3. Embryonic Stem Cells Repair Human Heart
4. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
5. Circulating fats kill transplanted pancreas cells, study shows
6. Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
7. Melanoma drug revs immune cells but cancer cells ignore it
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Embryonic stem cells used to grow cartilage
10. Molecular probe paints cancer cells in living animals, Stanford researchers find
11. USC researcher identifies stem cells in tendons that regenerate tissue in animal model
Post Your Comments:
Related Image:
Stem Cells Used for 'Biological Pacemaker'
(Date:11/26/2015)... ... November 26, 2015 , ... ... for mental health and wellness consultation, has collaborated with Women’s Web – ... their reader’s queries on topics on mental and emotional well-being relationship, life ...
(Date:11/25/2015)... , ... November 25, 2015 , ... ... where preparing the perfect dish and pleasing the palates of attendees is of ... bringing a dish to a seasonal get-together, give these recipes a try this ...
(Date:11/25/2015)... ... November 25, 2015 , ... Dr. John Pierce, Medical Director ... about hair loss treatment with the Capillus272™ Pro laser therapy cap. FDA cleared for ... and fuller hair, without the need for surgery, prescription pills, or topical foams. ...
(Date:11/25/2015)... ... November 25, 2015 , ... According to an article published November ... more widely heralded as a breakthrough for performing hernia repairs. The article explains that ... surgery is that it can greatly reduce the pain that a patient might otherwise ...
(Date:11/25/2015)... Raton, Florida (PRWEB) , ... November 25, 2015 ... ... diagnostic testing for physicians and athletic programs, launches new Wimbledon Athletics ... importance of testing young athletes for unsuspected cardiac abnormalities. About 2,000 people under ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , Nov. 25, 2015  Amgen (NASDAQ: ... License Application (BLA) with the United States ... ABP 501, a biosimilar candidate to Humira ® ... biosimilar application submitted to the FDA and represents Amgen,s ... Sean E. Harper , M.D., executive vice president ...
(Date:11/25/2015)... , Nov. 25, 2015  Linden Care, LLC, ... optimizing treatment outcomes for patients suffering from chronic pain, ... for a Temporary Restraining Order (TRO) enjoining Express Scripts ... two companies. --> --> ... all of its legal options. --> ...
(Date:11/25/2015)... 25, 2015 On Tuesday, November 24, ... trial against Wright Medical Technology, Inc. for product ... metal-on-metal hip implant device, awarded $11 million in ... week trial and three days of deliberations, the ... was defectively designed and unreasonably dangerous, and that ...
Breaking Medicine Technology: