Navigation Links
Stem Cells Show Promise as Heart Failure Treatment
Date:7/23/2012

MONDAY, July 23 (HealthDay News) -- Scientists who used modified stem cells to rejuvenate damaged and aged heart cells from elderly heart failure patients say their research could one day lead to new treatments for the illness.

"Since patients with heart failure are normally elderly, their cardiac stem cells aren't very healthy," Sadia Mohsin, one of the study authors and a postdoctoral research scholar at San Diego State University's Heart Institute, explained in a news release from the American Heart Association (AHA). "We modified these biopsied stem cells and made them healthier. It is like turning back the clock so these cells can thrive again."

The study was to be presented Monday at an AHA meeting, in New Orleans, and published simultaneously in the Journal of the American College of Cardiology.

The stem cells taken from the patients were modified with a protein called PIM-1, which promotes cells survival and growth. The modified stem cells helped the signaling and structure of the patients' heart cells by boosting the activity of an enzyme called telomerase, which elongates telomeres.

Telomeres are the caps on the ends of chromosomes that are involved in cell replication. Aging and disease occur when telomeres break off.

"There is no doubt that stem cells can be used to counter the aging process of cardiac cells caused by telomere degradation," Mohsin said.

While the study did use human heart cells, it was conducted in the laboratory and remains in its early stages. However, tests conducted in mice and pigs also found that telomere lengthening resulted in new heart tissue growth in just four weeks.

"Modifying aged human cardiac cells from elderly patients adds to the cell's ability to regenerate damaged heart muscle, making stem cell engineering a viable option," Mohsin said. "This is an especially exciting finding for heart failure patients. Right now we can only offer medication, heart transplantation or stem cell therapies with modest regenerative potential, but PIM-1 modification offers a significant advance for clinical treatment."

One expert called the research "exciting."

The stem cell technique "is enabling endogenous [the body's own] cardiac repair mechanisms to work more effectively," said Dr. Hina Chaudhry, director of cardiovascular regenerative medicine at the Mount Sinai School of Medicine, in New York City.

"Cell division does not normally occur at a clinically significant level in humans beyond birth and infancy," Chaudhry pointed out. "Given the somewhat marginal results of transplanting various stem cells into diseased hearts, the search for factors such as PIM-1 -- which appears to promote cell division and cell survival of native heart cells -- is a critical area of research."

More information

The U.S. National Heart, Lung, and Blood Institute has more about heart failure treatment.

-- Robert Preidt

SOURCES: Hina Chaudhry, M.D, director, cardiovascular regenerative medicine, Mount Sinai School of Medicine, New York City; American Heart Association, news release, July 23, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New drug prevents spread of human prostate cancer cells
2. Tiny hitchhikers attack cancer cells
3. To prevent leukemias dreaded return, go for the stem cells
4. Scientists identify major source of cells defense against oxidative stress
5. Therapy exploits addiction of leukemia cells
6. IBN discovers human neural stem cells with tumor targeting ability
7. Leukaemia cells have a remembrance of things past
8. Small molecular bodyguards kill HPV-infected cancer cells by protecting tumor-suppressor
9. Research yields new clues to how brain cancer cells migrate and invade
10. Presence of fetal cells in women lowers risk of breast cancer but raises risk of colon cancer
11. Researchers Rejuvenate Blood-Forming Stem Cells in Mice
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stem Cells Show Promise as Heart Failure Treatment
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House ... most popular and least understood books in the Holy Scriptures, Revelation. The Book of ... baffled scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), ... will showcase a range of technology and learning solutions at the 68th Annual ... Expo to be held October 14–18, 2017 at the Mandalay Bay Resort in ...
(Date:10/12/2017)... Bethesda, MD (PRWEB) , ... October 12, 2017 , ... ... Award of Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s ... 4 – 8. , In honor of Morris F. Collen, a pioneer in the ...
(Date:10/12/2017)... Washington, D.C. (PRWEB) , ... October 12, 2017 , ... ... of their peers in Washington, D.C., for the 49th Congress of the International ... Ph.D ., Vice President of the Center for Cancer and Blood Disorders ...
(Date:10/12/2017)... ... October 12, 2017 , ... Vohra Chief ... advancements to physician colleagues, skilled nursing facility medical directors and other clinicians at ... of Wound Care." , "At many of these conferences we get to educate ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)...  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided ... Piedras, Puerto Rico , where the ... Following a comprehensive onsite ... structural damage, temporary loss of power and minimal water ... manufacturing operations have resumed, and the company expects to ...
(Date:10/10/2017)... , Oct. 10, 2017   West Pharmaceutical ... innovative solutions for injectable drug administration, today shared the ... ID Adapter for improving the intradermal administration of polio ... Skin Vaccination Summit in May 2017 by Dr. ... Polio Department, World Health Organization (WHO), and recently published ...
(Date:10/5/2017)... Ill. , Oct. 5, 2017  In ... Association of Oral and Maxillofacial Surgeons (AAOMS) released ... opioids – to be used as a first-line ... pain. Recognizing ... the AAOMS White Paper "Opioid Prescribing: Acute and ...
Breaking Medicine Technology: