Navigation Links
Stem Cells Show Early Promise for Heart Problems
Date:11/7/2007

But far more research is needed to benefit heart attack patients, studies show

WEDNESDAY, Nov. 7 (HealthDay News) -- Scientists are edging toward a better understanding of how stem cells might one day restore function to damaged hearts.

Several studies presented Wednesday at the American Heart Association annual meeting, in Orlando, Fla., addressed different aspects of this promise.

One study found that patients' own stem cells, when injected into the heart after treatment for a heart attack, improved the heart's ability to pump effectively. But this finding is fairly preliminary.

"We're still learning. The area of stem cells still needs lots of understanding," said Dr. Robert Bonow, immediate past president of the heart association and chief of cardiology at Northwestern Memorial Hospital in Chicago. "What are the right kinds of cells? How do we train them into cells that are viable and make people better? What are the right kinds of patients? We really don't know that. We're waiting for more data."

The first study involved 80 patients who had recently received treatment (clot-busting drugs and angioplasty) for an ST elevation heart attack (STEMI), the more serious type of heart attack. The patients were randomly assigned to receive either injections of their own bone marrow cells or a placebo.

After six months, patients who had received bone marrow cell therapy saw their global ejection fraction, a measure of the heart's pumping function, improve from 59 percent to 67 percent. The ejection fraction remained unchanged in the placebo group.

"In conclusion, intracoronary injection of autologous [from the patient] bone marrow cells improves left ventricular systolic function in STEMI patients who are treated initially with thrombolytic therapy followed by [angioplasty] two to six days after a heart attack," said Dr. Heikki Huikuri, lead investigator of the trial and professor of medicine and director of the cardiology sector at the University of Oulu Hospital in Finland. "This appears to be a safe therapy."

Bonow added: "The findings are interesting but preliminary. The ejection fraction showed a meaningful increase, but they were normal to begin with. We need more time and more information."

The study was funded by the Finnish Academy of Science and Boston Scientific Inc.

Two other studies presented Wednesday in late-breaking sessions at the AHA meeting showed less convincing results. These studies looked at a different population than the Finnish study: patients with chronic scar tissue from a prior heart attack.

The first study involved injecting patients' own skeletal muscle stem cells directly into the heart. The trial, in 23 heart-failure patients, was primarily designed to assess safety, but the researchers also looked at effectiveness.

"These cells are not designed to be heart tissue, but they do contract and have some electrical activity," Bonow explained.

At one year, the procedure proved safe and, the study authors said, resulted in improvements in pumping function and better quality of life.

The study, however, was not "blinded," meaning that any improvements could be due to a placebo effect. Decreases in the heart's size were minimal, Bonow said.

"This doesn't lead anywhere right now," Bonow said.

The study was funded by Mytogen Inc., a biotech company developing cell-based therapies.

The final study, which involved injecting patients' own stem cells into heart scar tissue, found that it did not affect heart muscle functioning.

"It was safe but didn't improve systolic function, didn't reduce infarct size and didn't influence global left ventricular function," said study lead author Dr. Manuel Galinanes, professor of cardiac surgery at the University of Leicester in England.

More information

Basic facts about stem cell therapy are provided by the U.S. National Institutes of Health.



SOURCES: Robert Bonow, M.D., immediate past president, American Heart Association, and Goldberg Distinguished Professor, Northwestern University Feinberg School of Medicine, and chief, division of cardiology, Northwestern Memorial Hospital, Chicago; Nov. 7, 2007, presentation, American Heart Association annual meeting, Orlando, Fla., with Heikki Huikuri, M.D., professor of medicine and director of the cardiology sector at the University of Oulu Hospital, Oulu, Finland, and Manuel Galinanes, M.D., professor of cardiac surgery, University of Leicester, U.K.


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
2. Brain cells work differently than previously thought
3. Embryonic Stem Cells Repair Human Heart
4. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
5. Circulating fats kill transplanted pancreas cells, study shows
6. Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
7. Melanoma drug revs immune cells but cancer cells ignore it
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Embryonic stem cells used to grow cartilage
10. Molecular probe paints cancer cells in living animals, Stanford researchers find
11. USC researcher identifies stem cells in tendons that regenerate tissue in animal model
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stem Cells Show Early Promise for Heart Problems
(Date:5/26/2016)... ... 2016 , ... Georgia State University College of Law is ... Answering to the increasing demand for curricular specializations, the Certificate in Intellectual Property ... land use law. ,  , “The demand for lawyers with specific knowledge in ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cardiac arrhythmia is a ... on long-term patient survival, reports a team of UPMC researchers in the largest ... the Journal of Thoracic and Cardiovascular Surgery, provide critical information that will hopefully ...
(Date:5/26/2016)... , ... May 26, 2016 , ... ... Degeneration” for the Foundation Fighting Blindness, Long Island Chapter on June 4, 2016, ... public. , Dr. Maisel, founder of Retina Group of New York , ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... of healthcare supply chain solutions, today announced the organization has earned its ISO ... international standards and is compliant with all rules and policies associated with ISO ...
(Date:5/26/2016)... San Rafael, CA (PRWEB) , ... May 26, ... ... Studio will be offering campers a multitude of activities from daily practices, arts ... and self-confidence. , Camp Directors Amber East-D’Anna and Christy Evans have combined backgrounds ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... VMS BioMarketing as senior vice president of sales, announced Andrea Heslin Smiley , ... the company,s business development and sales team, exploring new opportunities for VMS to empower ... ... ... ...
(Date:5/24/2016)... 24, 2016 ... , la première endoprothèse à double thérapie ... l,intervention portant sur les membres inférieurs et ... OrbusNeich, entreprise mondiale spécialisée dans la fourniture ... vie, a élargi son portefeuille pour inclure ...
(Date:5/24/2016)... , May 24, 2016 ... elkaar verbindt, zodat zij collectief patiënten kunnen behandelen, hun ... is het idee achter de nieuwe en revolutionaire MDLinking ... van de Nederlandse vaatchirurg dr. Hans Flu en oncologisch ... app, die inmiddels beschikbaar is, wordt op dinsdag 24 ...
Breaking Medicine Technology: