Navigation Links
Stem Cells Modified to Home in Where They're Needed
Date:1/14/2008

Routing cue works like a Zip code helps deliver mail, researchers say

MONDAY, Jan. 14 (HealthDay News) -- U.S. researchers have found a way to modify the surface of stem cells to direct them to where they're needed, an advance that may prove useful in many areas of stem cell therapy.

Researchers at the Biomedical Research Institute at Brigham and Women's Hospital in Boston modified the surface of human mesenchymal stem cells -- a type of adult stem cell that's a precursor of bone-forming osteoblast cells. This modification directed the stem cells through the bloodstream into bone, where they matured into new bone cells.

"Without genetically reprogramming a stem cell, which could cause adverse effects, we were able to navigate the cell to a predetermined location -- a necessary first step toward achieving tissue regeneration," study lead author Dr. Robert Sackstein, a bone marrow transplant physician, said in a prepared statement.

"Stem cells must have a routing cue to traffic to where they're needed, just like you need a Zip code to deliver mail," Sackstein added.

In this study, he and his colleagues modified the surface of the stem cells to express the molecule HCELL, which is a homing receptor that seeks out the adhesion molecule E-selectin found on the lining of certain blood vessels, including those found in bone, the researchers said.

The modified stem cells were injected into mice, where they migrated to bone and made patches of human bone within the mouse bone.

The study was published online Jan. 13 and was expected to be in the February print issue of the journal Nature Medicine.

More information

The U.S. National Institutes of Health has more about stem cells.



-- Robert Preidt



SOURCE: Brigham and Women's Hospital, news release, Jan. 13, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
2. Brain cells work differently than previously thought
3. Embryonic Stem Cells Repair Human Heart
4. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
5. Circulating fats kill transplanted pancreas cells, study shows
6. Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
7. Melanoma drug revs immune cells but cancer cells ignore it
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Embryonic stem cells used to grow cartilage
10. Molecular probe paints cancer cells in living animals, Stanford researchers find
11. USC researcher identifies stem cells in tendons that regenerate tissue in animal model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: