Navigation Links
Stem Cells Might Treat Tough Fractures
Date:6/17/2008

In some cases, bones don't heal as they should, experts note

TUESDAY, June 17 (HealthDay News) -- Adult stem cell transplants can help improve healing of fractures, a finding that may lead to new treatments for the 10 percent to 20 percent of people whose broken bones fail to mend, say researchers at the University of North Carolina at Chapel Hill.

Adult stems cells are specialized cells that can regenerate damaged tissue, but many patients lack sufficient numbers of these cells, which means they can't heal properly, the researchers explained.

The UNC team used adult stem cells to heal fractures of the tibia (the long bone of the leg) in mice. The bone marrow-derived stem cells were engineered to express insulin-like growth factor 1 (IGF-1), which help bones grow in strength and size. The transplanted stem cells migrated to the site of the fracture and improved healing by increasing the bone and cartilage that bridged the break.

The bone at the fracture site of the mice that received stem cell transplants was three time stronger than healed fractures in untreated mice, the team reported.

The study was to have been presented Monday at the annual meeting of the Endocrine Society, in San Francisco.

"This finding is critical to patients who lack the proper healing process and to individuals prone to broken bones, such as those with osteoporosis and the rare genetic condition known as brittle bone disease," senior author Dr. Anna Spagnoli, associate professor of pediatrics and biomedical engineering in the UNC School of Medicine, said in a prepared statement.

During normal fracture healing, stem cells travel to the site of the break and form the cartilage and bone required to mend broken bones. But each year in the United States, doctors treat about 600,000 patients wherein this process doesn't occur as it should, and the bones don't heal. This can lead to long periods of immobilization, pain, bone deformities and even death.

Current therapies include multiple surgeries with bone autografts and artificial prosthetic materials. But these often fail to help patients.

"Man-made materials do not address the normal bone's function, and recurrent fractures, wear and toxicity are a real problem," Spagnoli said. "There is clearly a need to develop alternative therapies to enhance fracture healing in patients with bone union failure."

More information

The American Academy of Orthopaedic Surgeons has more about fractures.



-- Robert Preidt



SOURCE: University of North Carolina at Chapel Hill, news release, June 16, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Penn researchers find key developmental pathway activates lung stem cells
2. Team discovers new inhibitors of estrogen-dependent breast cancer cells
3. New therapy shows promise for fighting treatment-resistant cancer cells
4. Ability to track stem cells in tumors could advance cancer treatments
5. Primary Tumors Fuel Growth of Cancer Cells
6. Solid tumor cells not killed by radiation and chemotherapy become stronger
7. Finding the source: Cells that initiate a common infant tumor identified
8. Brain Stem Cells Reverse Myelin Deficiency in Mice
9. A new way to think about Earths first cells
10. Researchers ID Inflammation-Fighting Pathway in Fat Cells
11. Gene that magnetically labels cells shows potential as imaging tool
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stem Cells Might Treat Tough Fractures
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... ... Talented host, actor Rob Lowe, is introducing a segment ... of "Success Files," which is an award-winning educational program broadcasted on PBS Member ... with passion and integrity. , Sciatica occurs when the sciatic nerve in the ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and the loss ... author, William Nowers. Captain Nowers and his wife, Millie, have six children, ten ... the Navy. Following his career as a naval aviator and carrier pilot, he ...
(Date:10/12/2017)... ... 2017 , ... Planet Fitness, one of the largest and fastest growing franchisors ... a flagship location in Covington, LA at 401 N. U.S. Highway 190, in January ... Office Depot in the Holiday Square shopping center. Its location allows it to serve ...
(Date:10/12/2017)... , ... October 12, 2017 , ... The American College ... to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in ... , In honor of Morris F. Collen, a pioneer in the field of medical ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Lilly and Company (NYSE: LLY ) will ... 2017 on Tuesday, October 24, 2017. Lilly will also ... investment community and media to further detail the company,s ... at 9 a.m. Eastern time. Investors, media and the ... conference call through a link that will be posted ...
(Date:9/28/2017)... Sept. 28, 2017 Cohen Veterans Bioscience and ... use of wearable and home sensors for real-time monitoring ... Signal Foundation, a nonprofit organization focused on disruptive health ... an affordable analytical system to record and integrate behavioral, ... ...
(Date:9/23/2017)... , Sept. 22, 2017 Janssen Biotech, Inc. ... response letter from the U.S. Food and Drug Administration ... of sirukumab for the treatment of moderately to severely ... additional clinical data are needed to further evaluate the ... severely active RA. ...
Breaking Medicine Technology: