Navigation Links
Stem Cells Might Reverse Heart Damage From Chemo
Date:12/30/2009

Cancer patients could one day take potent therapies, get heart fixed later, researchers say ,,

WEDNESDAY, Dec. 30 (HealthDay News) -- Certain types of chemotherapy can damage the heart while thwarting cancer, a dilemma that has vexed scientists for years. But a new study in rats finds that injecting the heart with stem cells can reverse the damage caused by a potent anti-cancer drug.

The findings could one day mean that cancer patients could safely take higher doses of a powerful class of chemotherapy drugs and have any resulting damage to their hearts repaired later on using their own cardiac stem cells, the researchers said.

The study was published online Dec. 28 in advance of print publication in the journal Circulation.

Doxorubicin is a common chemotherapy drug used to treat many types of cancer, including breast, ovarian, lung, thyroid, neuroblastoma, lymphoma and leukemia.

But the drug can have serious side effects, including heart damage that can lead to congestive failure years after cancer treatment ends.

In the study, researchers removed cardiac stem cells from rodents before chemotherapy. The stem cells were isolated and expanded in the lab.

Rats were then given the chemo drug doxorubicin, inducing heart failure. Afterward, the rats' stem cells were re-injected into their hearts, and the damage was reversed.

"Theoretically, patients could be rescued using their own stem cells," said study author Dr. Piero Anversa, director of the Center for Regenerative Medicine at Brigham and Women's Hospital in Boston.

A Phase 1 clinical trial using a similar procedure in people is already under way, said Dr. Roberto Bolli, chief of cardiology and director of the Institute of Molecular Cardiology at the University of Louisville in Kentucky, who is heading the trial.

His lab has U.S. Food and Drug Administration approval to treat 30 patients who have
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
2. Brain cells work differently than previously thought
3. Embryonic Stem Cells Repair Human Heart
4. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
5. Circulating fats kill transplanted pancreas cells, study shows
6. Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
7. Melanoma drug revs immune cells but cancer cells ignore it
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Embryonic stem cells used to grow cartilage
10. Molecular probe paints cancer cells in living animals, Stanford researchers find
11. USC researcher identifies stem cells in tendons that regenerate tissue in animal model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... is a famous wedding dress company offering many trendy designs. ... Facebook, Twitter, and Pinterest. The fans will have an opportunity ... every week. , Moreover, the company has extended its 2015 ... homepage for more information. , Angelweddingdress is a ...
(Date:1/22/2015)... Juvent Sports ( http://www.juventsports.com ) and David Leadbetter ... to bestow a Juvent Sports Achievement award upon an ... The award commemorated and congratulated McKitrick for her record ... her first amateur tournament in 1979 and most recently ...
(Date:1/22/2015)... For over 20 years, Dr. David Cruz of Cruz Chiropractic ... treated just about every type of injury that can result from ... same twenty-plus years, the team at Doctors on Liens ... possible doctor. With the combined breadth of experience between ...
(Date:1/22/2015)... Jolla, Calif. (PRWEB) January 22, 2015 ... Assemblymembers Susan Bonilla (D-Concord) and Kristin Olsen (R-Modesto) ... for their leadership in advancing biotechnology, biomedical science, ... Bonilla and Olsen each received the “2014 Life ...
(Date:1/22/2015)... DC (PRWEB) January 22, 2015 Payday ... in vulnerable communities and cause financial distress to the ... by analysts at Howard University’s Center on Race and ... dollars in economic activity, payday loans at the same ...
Breaking Medicine News(10 mins):Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2
... HUNTSVILLE, TX -- Texas employers can learn about the ... an inaugural program being held at Sam Houston State ... be available to all Texas employers after Sept. 1, ... Transportation (TxDOT), will target 600 Texas employers, including human ...
... , Montreal, June 13, 2011 Exposure to secondhand smoke ... to a new study from Concordia University and the University ... Nicotine & Tobacco Research , the study also found that ... consuming cigarettes are more likely to light up themselves as ...
... cancer survivors. On average, their medical care costs $4,000 to ... never had cancer, according to Penn State researchers. ... to later health complications and their total medical expenses average ... the moment they are diagnosed through the end of their ...
... Large corporations could save millions of dollars in lost ... sleep apnea, suggests a research abstract that will be ... 2011, the 25th Anniversary Meeting of the Associated Professional ... corporation in Florida could save an estimated $136 million ...
... Sleep apnea is associated with an increased risk of ... be presented Monday, June 13, in Minneapolis, Minn., at ... Professional Sleep Societies LLC (APSS). Results show that ... of adverse pregnancy outcomes. This increased prevalence was ...
... Storey, Professor of Cardiology at the University of Sheffield,s ... one in five deaths in the year following a ... ticagrelor, was used instead of the standard treatment, clopidogrel. ... British Cardiovascular Society annual scientific conference in Manchester today ...
Cached Medicine News:Health News:Drug recognition program available for Texas employers 2Health News:Preteens surrounded by smokers get hooked on nicotine 2Health News:Cancer survivors spend more on health care 2Health News:Screening high-risk employees for sleep apnea could save a corporation millions of dollars 2Health News:Screening high-risk employees for sleep apnea could save a corporation millions of dollars 3Health News:Sleep apnea may increase the risk of adverse pregnancy outcomes 2Health News:1 in 5 heart-attack deaths could be prevented with new drug 2Health News:1 in 5 heart-attack deaths could be prevented with new drug 3
(Date:1/23/2015)... N.Y. , Jan. 23, 2015  Lixte Biotechnology Holdings, Inc. ... its Phase I trial of Lixte,s lead compound, LB‑100, is ... John S. Kovach , M.D., the founder ... planned to be completed at a single site. Accrual of ...
(Date:1/23/2015)... , Jan. 23, 2015   Leatt Corporation  (OTCQB: ... protective equipment for all forms of sports, including extreme ... neck brace, announced today that the UISP Lega Motociclismo ... requires all riders to wear a neck brace during ...
(Date:1/23/2015)... 23, 2015  Mallinckrodt plc (NYSE: MNK ) ... a share repurchase program. The open-ended authorization permits the ... plc ordinary shares. "Funding additional initiatives ... as we continue to pursue a range of focused ...
Breaking Medicine Technology:Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 2Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 3Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 3Mallinckrodt plc Announces Share Repurchase Program 2Mallinckrodt plc Announces Share Repurchase Program 3Mallinckrodt plc Announces Share Repurchase Program 4
... WASHINGTON, Aug. 30, 2011 Public Citizen filed a petition ... the FDA should revise its rules that bar generic drug ... drug makers should be allowed to ask the FDA to ... to patients who take their drugs. Reporters developing a story ...
... 29, 2011 Laboratory Supply Company (LABSCO), the largest ... products to hospitals, physician office laboratories, reference labs and ... to expand its executive leadership team with the new ... financial officer. Willett,s career has included over ...
Cached Medicine Technology:LABSCO Hires George Willett as New Vice President and Chief Financial Officer 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: