Navigation Links
Stem Cells Might One Day Treat Severe Asthma
Date:3/15/2010

Mouse study suggests treatment aimed at immune system could work in humans

MONDAY, March 15 (HealthDay News) -- Stem cells may one day be a viable treatment for people suffering from severe asthma, researchers say.

A new study published online in the March 15-19 early edition of the Proceedings of the National Academy of Sciences borrowed its idea from the field of organ transplantation, where multipotent stem cells in the form of bone marrow transplants are already used to reduce the risk of rejection in patients who have received donated organs.

Senior study author Dr. Eva Mezey, head of the adult stem cell unit at the National Institute of Dental and Craniofacial Research (NIDCR), cautioned that this was an early-stage experiment conducted only in mice, and humans shouldn't get too excited just yet.

"On the one hand, people should be cautious that it might not be just as good in people. However, there are many human studies that have proven that these cells are able to modulate the immune system and tip the balance back to normal when the balance is gone," she said. "It's very likely that the intervention would work in humans."

But clinical trials will depend on working out numerous details, including how the therapy would be delivered. In the mice, the stem cells were injected but aerosol administration might work better in humans, producing a more local result instead of systemic effects and, probably, fewer side effects, she noted.

And this stem cell therapy, if it ever reaches patients, is likely to be reserved for those who haven't responded to other therapies. "Basically, you would think of this therapy in cases where patients are resistant to existing treatment," Mezey explained.

Some 16 million people in the United States have asthma, and the incidence seems to be on the rise.

Because bone marrow transplants quell immune responses in transplant patients, the idea was that it might be beneficial in individuals with other immune-based diseases such as asthma.

Here, the investigators used mice that had been engineered to be allergic to ragweed and injected them with multipotent stem cells known as bone marrow stromal cells. Multipotent stem cells are cells that can develop into many different cell types.

Indeed, animals injected with the compound had fewer allergy and asthma symptoms when exposed to the allergen, ragweed.

"We gave the mice intravenous injections of stem cells and, after four days, we assessed different mediators of the inflammatory response and that's how we could pick up the beneficial effects of the stem cells," said study first author Dr. Krisztian Nemeth, a research fellow with the adult stem cell unit of NIDCR.

After that, he added, "we went into more accurate details and tried to explore what anti-inflammatory molecules were synthesized by our cells and how they mediated the anti-inflammatory response."

It turned out that the stem cells righted the balance of certain white blood cells that are out of sync in those with asthma.

More information

The U.S. National Heart, Lung, and Blood Institute has more on asthma.



SOURCES: Eva Mezey, M.D., Ph.D., head, adult stem cell unit, National Institute of Dental and Craniofacial Research (NIDCR); Krisztian Nemeth, M.D., Ph.D., research fellow, adult stem cell unit, NIDCR; March 15-19, 2010, Proceedings of the National Academy of Sciences, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. 3-D cell culture: Making cells feel right at home
2. Amniotic fluid cells more efficiently reprogrammed to pluripotency than adult cells
3. Scientists Find Stem Cells in Hair That Can Become Skin
4. Autologous Bone Marrow Stem Cells Transplant into Parkinson's Disease Patients is Safe and May Improve Their Quality of Life
5. University of Michigan scientists discover bone marrow can harbor HIV-infected cells
6. HIV Hides Out in Bone Marrow Cells
7. Periodontal pathogens enhance HIV-1 promoter activation in T cells
8. Cells of aggressive leukemia hijack normal protein to grow
9. Notch-blocking drugs kill brain cancer stem cells, yet multiple therapies may be needed
10. Heart Stem Cells Move Closer to Human Treatments
11. Bitter melon extract attacks breast cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... June 19, ... the dangers associated with chronic pain and the benefits of holistic treatments, Serenity ... who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a ...
(Date:6/24/2016)... ... 2016 , ... The Pulmonary Hypertension Association (PHA) learned during ... two significant new grants to support its work to advance research and patient ... recognizing patients, medical professionals and scientists for their work in fighting pulmonary hypertension ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be ...
(Date:6/24/2016)... ... ... makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum ... by 2020 and then adjusting it yearly to increase at the same rate as the ... wage floor does not erode again, and make future increases more predictable. , The company ...
(Date:6/24/2016)... ... 24, 2016 , ... EB Medicine presented its first-ever “Issue ... conference in Ponte Vedra Beach, FL. The awards honor the outstanding work of ... and Pediatric Emergency Medicine Practice. , “With this award, we recognize the ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... Markets has announced the addition of the " ... offering. This ... and provides an updated review, including its applications in ... the total market, which includes three main industries: pharmaceutical ...
(Date:6/24/2016)... BEIJING , June 24, 2016 Dehaier ... or the "Company"), which develops, markets and sells medical ... China , signed a strategic cooperation agreement with ... as "Hongyuan Supply Chain") on June 20, 2016, to ... Under the strategic cooperation agreement, Dehaier will leverage Hongyuan ...
(Date:6/24/2016)... 2016 According to a new ... Pen Needles, Safety Pen Needles), Needle Length (4mm, 5mm, ... Mode of Purchase (Retail, Non-Retail) - Trends & Global ... the market for the forecast period of 2016 to ... Billion by 2021 from USD 1.65 Billion in 2016, ...
Breaking Medicine Technology: