Navigation Links
Stem Cells Might One Day Treat Severe Asthma
Date:3/15/2010

Mouse study suggests treatment aimed at immune system could work in humans

MONDAY, March 15 (HealthDay News) -- Stem cells may one day be a viable treatment for people suffering from severe asthma, researchers say.

A new study published online in the March 15-19 early edition of the Proceedings of the National Academy of Sciences borrowed its idea from the field of organ transplantation, where multipotent stem cells in the form of bone marrow transplants are already used to reduce the risk of rejection in patients who have received donated organs.

Senior study author Dr. Eva Mezey, head of the adult stem cell unit at the National Institute of Dental and Craniofacial Research (NIDCR), cautioned that this was an early-stage experiment conducted only in mice, and humans shouldn't get too excited just yet.

"On the one hand, people should be cautious that it might not be just as good in people. However, there are many human studies that have proven that these cells are able to modulate the immune system and tip the balance back to normal when the balance is gone," she said. "It's very likely that the intervention would work in humans."

But clinical trials will depend on working out numerous details, including how the therapy would be delivered. In the mice, the stem cells were injected but aerosol administration might work better in humans, producing a more local result instead of systemic effects and, probably, fewer side effects, she noted.

And this stem cell therapy, if it ever reaches patients, is likely to be reserved for those who haven't responded to other therapies. "Basically, you would think of this therapy in cases where patients are resistant to existing treatment," Mezey explained.

Some 16 million people in the United States have asthma, and the incidence seems to be on the rise.

Because bone marrow transplants quell immune responses in transplant patients, the idea was that it might be beneficial in individuals with other immune-based diseases such as asthma.

Here, the investigators used mice that had been engineered to be allergic to ragweed and injected them with multipotent stem cells known as bone marrow stromal cells. Multipotent stem cells are cells that can develop into many different cell types.

Indeed, animals injected with the compound had fewer allergy and asthma symptoms when exposed to the allergen, ragweed.

"We gave the mice intravenous injections of stem cells and, after four days, we assessed different mediators of the inflammatory response and that's how we could pick up the beneficial effects of the stem cells," said study first author Dr. Krisztian Nemeth, a research fellow with the adult stem cell unit of NIDCR.

After that, he added, "we went into more accurate details and tried to explore what anti-inflammatory molecules were synthesized by our cells and how they mediated the anti-inflammatory response."

It turned out that the stem cells righted the balance of certain white blood cells that are out of sync in those with asthma.

More information

The U.S. National Heart, Lung, and Blood Institute has more on asthma.



SOURCES: Eva Mezey, M.D., Ph.D., head, adult stem cell unit, National Institute of Dental and Craniofacial Research (NIDCR); Krisztian Nemeth, M.D., Ph.D., research fellow, adult stem cell unit, NIDCR; March 15-19, 2010, Proceedings of the National Academy of Sciences, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. 3-D cell culture: Making cells feel right at home
2. Amniotic fluid cells more efficiently reprogrammed to pluripotency than adult cells
3. Scientists Find Stem Cells in Hair That Can Become Skin
4. Autologous Bone Marrow Stem Cells Transplant into Parkinson's Disease Patients is Safe and May Improve Their Quality of Life
5. University of Michigan scientists discover bone marrow can harbor HIV-infected cells
6. HIV Hides Out in Bone Marrow Cells
7. Periodontal pathogens enhance HIV-1 promoter activation in T cells
8. Cells of aggressive leukemia hijack normal protein to grow
9. Notch-blocking drugs kill brain cancer stem cells, yet multiple therapies may be needed
10. Heart Stem Cells Move Closer to Human Treatments
11. Bitter melon extract attacks breast cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2017)... ... July 24, 2017 , ... Cheerag D. Upadhyaya , M.D., M.Sc., ... Neuroscience Institute (SLMBNI), part of Saint Luke’s Health System . Dr. Upadhyaya ... D. Upadhyaya, MD. M.Sc., FAANS joins Stanley P. Fisher, M.D., who has ...
(Date:7/24/2017)... , ... July 24, 2017 , ... ... (MCPS) have partnered together for a unique opportunity that helps high school girls succeed ... “Removing Barriers, Creating Opportunities.” Horizon Goodwill will host over 20 high school ...
(Date:7/24/2017)... ... July 24, 2017 , ... Every year, thousands of ... educational conference, InstructureCon. Each annual event is coupled with a dynamic theme like Camp ... James Bond theme, Mission: InstructureCon 0017. , To extend their partnership with Canvas ...
(Date:7/24/2017)... ... July 24, 2017 , ... A CDC study shows that, although people are taking ... (ages 18 to 29), had at least one case of sunburn within the past year. ... causes people to ignore the issue. However, only recently have people become conscientious of the ...
(Date:7/24/2017)... ... ... Sharon Kleyne, host of the nationally syndicated The Sharon Kleyne Hour Power ... EyeMist® recently talked on the air about an alarming Post magazine article of April ... Aldama described the situation in which Chinese children are under pressure to perform academically ...
Breaking Medicine News(10 mins):
(Date:7/21/2017)... SPRING, Md. and RESEARCH TRIANGLE ... United Therapeutics Corporation (NASDAQ: UTHR ) announced ... financial results before the market opens on Thursday, July ... Therapeutics will host a teleconference on Thursday, July 27, ... accessible by dialing 1-877-351-5881, with international callers dialing 1-970-315-0533.  ...
(Date:7/17/2017)...  MedX Holdings, Inc., the manufacturer and global distributor ... equipment, today announced the national roll out of its ... gold standard for the treatment of low back injuries ... How it works: ... practice who prescribe the MedX Home Back Machine Program ...
(Date:7/13/2017)... July 13, 2017 RK Logistics Group, Inc. was ... certification for its Fremont, CA headquarters ... the Tri-Valley and San Jose for ... of Fremont , with its Fremont Innovation District, is ... such a powerful resource to the hundreds of biotech, pharma ...
Breaking Medicine Technology: