Navigation Links
Stem Cells From Testes Produce Wide Range of Tissue Types

Work with mice might lead to treatments for diseases such as diabetes and Alzheimer's

WEDNESDAY, Sept. 19 (HealthDay News) -- U.S. researchers say they've successfully reprogrammed adult stem cells from the testes of male mice into a wide variety of cell types, including functional blood vessels, contractile cardiac tissue, and brain cells.

If the same can be done with adult testes stem cells from humans, they may offer a source of new therapies to treat men with health problems such as heart disease, vascular diseases, diabetes, stroke, Parkinson's, Alzheimer's, and even cancer, the researchers said.

The study, by Howard Hughes Medical Institute scientists, is published in the Sept. 20 issue of the journal Nature.

Only a small subset of adult testes cells have the ability to develop into multiple cell types. Until now, scientists haven't had the means to identify and isolate these stem cells.

In this new study, the researchers reported that they had identified a novel cell surface marker called GPR125 that's expressed on a unique set of cells within adult testes -- spermatogonial stem and progenitor cells (SPCs).

Using GPR125, the scientists were able to identify and harvest a large number of SPCs from adult mouse testes. In the lab, the team propagated and reprogrammed the SPCs to become stem cells that could differentiate into a variety of cell types.

"It appears that these specialized GPR125-positive spermatogonial cells could be an easily obtained and manipulated source of stem cells with a similar capability to form new tissues that we see in embryonic stem cells," study author Shahin Rafii, of Weill Cornell Medical College in New York City, said in a prepared statement.

For male patients, this "could someday mean a readily available source of stem cells that gets around ethical issues linked to embryonic stem cells. It also avoids issues linked to tissue transplant rejection, since these autologous cells come from the patient's own body," Rafii said.

More information

The U.S. National Institutes of Health has more about stem cells.

-- Robert Preidt

SOURCE: Howard Hughes Medical Institute, news release, Sept. 19, 2007

Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Blood Cells Capable of Regenerating Liver
2. White Cells Count Can Predict Heart Attack Death Risk
3. Action of nerve cells
4. Common Cold Found to Fight Cancer Cells
5. Integrin helps healing process in cells
6. Therapy for stopping the spread of cancer cells
7. Hydroxyurea derivatives kill colon cancer cells
8. Gene Therapy Destroys Pancreatic Cancer Cells
9. Creating brain cells from bone marrow
10. A Chinese herb kills cancer cells
11. Immune cells halt round in space
Post Your Comments:
(Date:6/27/2016)... ... ... recently awarded their highest five-star rating to Best Buy Eyeglasses, an ... United States and Canada wear eyeglasses. Once considered to be a purely functional part ... fashion statement. Even celebrities use glasses as a way of creating an iconic image—like ...
(Date:6/26/2016)... Battle Creek, Michigan (PRWEB) , ... June 26, 2016 , ... ... abuse, joined as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table ... held in honor of the city’s history as home to some of the world’s ...
(Date:6/26/2016)... ... 2016 , ... PawPaws brand pet supplements owned by Whole Health ... the health of felines. The formula is all-natural and is made from Chinese herbs ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia ...
(Date:6/26/2016)... , ... June 26, 2016 , ... ... once they have been diagnosed with endometriosis. These women need a treatment plan ... require a comprehensive approach that can help for preservation of fertility and ultimately ...
(Date:6/25/2016)... ... 25, 2016 , ... Austin residents seeking Mohs surgery services, can now turn ... to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization ... selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research ... Devices Global Market - Forecast to 2022" report to ... the treatment method for the patients with kidney failure, it ... excess fluid from the patient,s blood and thus the treatment ... potassium and chloride in balance. Increasing number ...
(Date:6/23/2016)... June 23, 2016  In a startling report released today, ... residents by lacking a comprehensive, proven plan to eliminate prescription opioid ... ranking of how states are tackling the worst drug crisis in ... states – Kentucky , New Mexico ... . Of the 28 failing states, three – ...
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on the ... announced that patient enrollment in its ongoing randomized ... has exceeded 50% of its 24-patient target. Capricor ... the third quarter of 2016, and to report ...
Breaking Medicine Technology: