Navigation Links
Stem Cells From Testes Produce Wide Range of Tissue Types
Date:9/19/2007

Work with mice might lead to treatments for diseases such as diabetes and Alzheimer's

WEDNESDAY, Sept. 19 (HealthDay News) -- U.S. researchers say they've successfully reprogrammed adult stem cells from the testes of male mice into a wide variety of cell types, including functional blood vessels, contractile cardiac tissue, and brain cells.

If the same can be done with adult testes stem cells from humans, they may offer a source of new therapies to treat men with health problems such as heart disease, vascular diseases, diabetes, stroke, Parkinson's, Alzheimer's, and even cancer, the researchers said.

The study, by Howard Hughes Medical Institute scientists, is published in the Sept. 20 issue of the journal Nature.

Only a small subset of adult testes cells have the ability to develop into multiple cell types. Until now, scientists haven't had the means to identify and isolate these stem cells.

In this new study, the researchers reported that they had identified a novel cell surface marker called GPR125 that's expressed on a unique set of cells within adult testes -- spermatogonial stem and progenitor cells (SPCs).

Using GPR125, the scientists were able to identify and harvest a large number of SPCs from adult mouse testes. In the lab, the team propagated and reprogrammed the SPCs to become stem cells that could differentiate into a variety of cell types.

"It appears that these specialized GPR125-positive spermatogonial cells could be an easily obtained and manipulated source of stem cells with a similar capability to form new tissues that we see in embryonic stem cells," study author Shahin Rafii, of Weill Cornell Medical College in New York City, said in a prepared statement.

For male patients, this "could someday mean a readily available source of stem cells that gets around ethical issues linked to embryonic stem cells. It also avoids issues linked to tissue transplant rejection, since these autologous cells come from the patient's own body," Rafii said.

More information

The U.S. National Institutes of Health has more about stem cells.



-- Robert Preidt



SOURCE: Howard Hughes Medical Institute, news release, Sept. 19, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Blood Cells Capable of Regenerating Liver
2. White Cells Count Can Predict Heart Attack Death Risk
3. Action of nerve cells
4. Common Cold Found to Fight Cancer Cells
5. Integrin helps healing process in cells
6. Therapy for stopping the spread of cancer cells
7. Hydroxyurea derivatives kill colon cancer cells
8. Gene Therapy Destroys Pancreatic Cancer Cells
9. Creating brain cells from bone marrow
10. A Chinese herb kills cancer cells
11. Immune cells halt round in space
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... May 04, 2016 , ... ... Rider's research and development of DRACO broad-spectrum antiviral therapeutics. DRACOs have proven effective ... starts on May 3, 2016 at http://igg.me/at/EndTheVirus and runs for 60 ...
(Date:5/4/2016)... , ... May 04, 2016 , ... ... Continence Nurses (WOCN) Society™ and Canadian Association for Enterostomal Therapy (CAET) will ... time saving and planning tools to attendees and exhibitors for the 2016 WOCN ...
(Date:5/4/2016)... Dallas, Texas (PRWEB) , ... May 04, 2016 , ... ... cancer awareness in people across the United States. Dermatologist Dr. Ellen Turner is encouraging ... heed dermatology experts’ advice and focus on skin safety and health now and in ...
(Date:5/4/2016)... ... , ... Recognizing that lifestyle medicine is essential to health and healthcare, ... Katz, MD, MPH, president of the American College of Lifestyle Medicine, as their first ... gratifying,” said Katz. “There is so much opportunity to add years to lives, and ...
(Date:5/4/2016)... ... 2016 , ... Bayco Products has announced the introduction of ... in models NSP-9842XL and NSR-9844XL . , First previewed at SHOT Show ... included CR-123 batteries to produce up to 650 lumens in a variety of ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... DUBLIN , May 4, 2016 /PRNewswire/ ... the addition of the  "Global Multiple Myeloma ...  report to their offering.       ... Multiple Myeloma Market and Competitive Landscape Highlights ... pipeline products, Multiple Myeloma epidemiology, Multiple Myeloma ...
(Date:5/4/2016)... Research and Markets has ... Keratosis Market and Competitive Landscape Highlights - ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ... Highlights 2016, provides comprehensive insights into Actinic ... Keratosis market valuations and forecast, Actinic Keratosis ...
(Date:5/3/2016)... May 3, 2016 BioNovus Innovations LLC ... for Advancing Medical Innovation (IAMI) today announced a ... diagnostics and medical devices. An agreement ... rights to license, develop and commercialize medical innovations ... "This partnership represents a significant advance in ...
Breaking Medicine Technology: