Navigation Links
Stem Cell Therapy Shows Promise in Repairing Brain Damage Even Hours After Stroke Occurs
Date:8/9/2013

Durham, NC (PRWEB) August 09, 2013

Stroke is a major health concern and is a leading cause of death in the United States, according to the Center for Disease Control. Despite significant research efforts, developing treatments that ensure complete recovery for stroke patients poses an extreme challenge, especially when more than a few hours have passed between onset of the stroke and administration of treatment.

However, a new study released today in STEM CELLS Translational Medicine indicates that endothelial precursor cells, which are found in the bone marrow, umbilical cord blood, and as very rare cells in peripheral blood, could make a significant difference for these patients’ recovery — even in the later stages of stroke. In animal studies, the treatment minimized the initial brain injury and helped repair the stroke damage.

“Previous studies indicated that stem/progenitor cells derived from human umbilical cord blood (hUCB) improved functional recovery in stroke models,” noted Branislava Janic, Ph.D., a member of Henry Ford Health System’s Cellular and Molecular Imaging Laboratory in Detroit and lead author of the study. “We wanted to examine the effect of hUCB-derived AC133+ endothelial progenitor cells (EPCs) on stroke development and resolution in rats.”

Dr. Janic and his team injected rats that had suffered strokes with the stem cells. When they later examined the animals using MRI, they found that the transplanted cells had selectively migrated to the injured area and that the stem cells stopped the tissue damage from spreading, instigated regeneration, and also affected the time course for stroke resolution. A significant decrease in lesion size also was observed, at a dose of 10 million cells, as early as seven days after the stroke’s onset.

“This led us to conclude that cord blood-derived EPCs can significantly contribute to developing more effective treatments that allow broader time period for intervention, minimize the initial brain injury and help repair the damage in later post-stroke phases,” Dr. Janic said.

“The early signs of stroke are often unrecognized, and many patients cannot take advantage of clot-busting treatments within the required few hours after stroke onset,” said Anthony Atala, M.D., editor of STEM CELLS Translational Medicine and director of the Wake Forest Institute for Regenerative Medicine. “In this animal study, a combination of stem cells shows promise for healing stroke damage when administered 24 hours after the stroke.”
###

The full article, “Intravenous administration of human umbilical cord blood derived AC133+ endothelial progenitor cells in rat stroke model reduces infarct volume — magnetic resonance imaging (MRI) and histological findings,” can be accessed at http://www.stemcellstm.com.

About STEM CELLS Translational Medicine: STEM CELLS TRANSLATIONAL MEDICINE (SCTM), published by AlphaMed Press, is a monthly peer-reviewed publication dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology. By bridging stem cell research and clinical trials, SCTM will help move applications of these critical investigations closer to accepted best practices.

About AlphaMed Press: Established in 1983, AlphaMed Press with offices in Durham, NC, San Francisco, CA, and Belfast, Northern Ireland, publishes two other internationally renowned peer-reviewed journals: STEM CELLS® (http://www.StemCells.com), in its 31th year, is the world's first journal devoted to this fast paced field of research. The Oncologist® (http://www.TheOncologist.com), also a monthly peer-reviewed publication, in its 18th year, is devoted to community and hospital-based oncologists and physicians entrusted with cancer patient care. All three journals are premier periodicals with globally recognized editorial boards dedicated to advancing knowledge and education in their focused disciplines.

Read the full story at http://www.prweb.com/releases/2013/8/prweb11012046.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. Athletico Physical Therapy Opens in Greenfield, Wisconsin
2. New therapy strategy could help treat cancer that has spread from breast to brain
3. Immune system molecule promotes tumor resistance to anti-angiogenic therapy
4. Blocking key enzyme in cancer cells could lead to new therapy
5. Therapy for severe vasculitis shows long-term effectiveness
6. Fertility therapy not associated with long-term cardiovascular disease
7. Winners of the 39th Maddak Awards Competition for Innovative Product Design Announced at 2013 American Occupational Therapy Association Conference
8. Long Island Pulse Magazine Features Hands On HealthCare Massage Therapy and Wellness Day Spa in an Article on Spa Parties
9. Study shows combination stroke therapy safe and effective
10. Inhalable gene therapy may help pulmonary arterial hypertension patients
11. University of Western States Massage Therapy Program Receives Accreditation from Commission on Massage Therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2017)... TX (PRWEB) , ... June 26, 2017 , ... ... their coding staff, and consumers are seeing lots of red these days. According ... contain inaccurate charges that result from medical coding errors(1). Some studies point to ...
(Date:6/26/2017)... (PRWEB) , ... June 26, 2017 , ... New patients ... from Dr. Angela Cotey, with or without a referral. Dr. Cotey is a trusted ... of this preferred tooth replacement option. , Patients with missing teeth in Fitchburg, WI, ...
(Date:6/25/2017)... Aliso Viejo, CA (PRWEB) , ... June 24, 2017 , ... Create a feel-good lyric ... place presets above footage and sound in the timeline and write in the lyrics to ... screen before flying back out. Each line of the text can be added modularly for ...
(Date:6/25/2017)... ... , ... An increase in wetter weather in the Northern California area naturally ... a humdinger of an allergy season. A relief from drought conditions is most welcome, ... and weed pollen. , “Our patients have been reporting the typical allergy season ...
(Date:6/25/2017)... ... June 25, 2017 , ... With a heatwave currently bearing down on Northern California ... at the pool. Being swimsuit ready is easy with laser hair removal. , The ... can be a burdensome routine when all you want to do is get out, dive ...
Breaking Medicine News(10 mins):
(Date:6/7/2017)... GAITHERSBURG, Md. , June 7, 2017  Novavax, Inc., ... the second of two Phase 2 trials of its RSV ... women of child bearing age have been published in the ... this publication have been shared in prior scientific conferences). The ... trial in April 2014. Novavax is developing the RSV F ...
(Date:6/2/2017)...  NxStage Medical, Inc. (Nasdaq:  NXTM), a leading medical technology company ... demonstrating positive biochemical outcomes related to more frequent hemodialysis ... will be presented at the ERA-EDTA Congress being held ... . The research was conducted by ... Europe (KIHDNEy) Cohort team ...
(Date:5/29/2017)... Israel, May 29, 2017  Cellect Biotechnology Ltd. (NASDAQ: ... technology which enables the functional selection of stem cells, ... for the first quarter ended March 31 st , ... our accomplishments in the first quarter of 2017," said ... quarter, we announced the treatment of the first blood ...
Breaking Medicine Technology: