Navigation Links
Stem Cell Therapy Reversed Chemo-Linked Infertility in Male Monkeys
Date:11/2/2012

FRIDAY, Nov. 2 (HealthDay News) -- It might be possible one day to restore male fertility after cancer chemotherapy, new research with monkeys suggests.

Some cancer drugs are designed to destroy rapidly dividing cells, but can't tell the difference between cancer cells and other rapidly dividing cells in the body, including sperm-producing stem cells. As a result, these cells can be wiped out and leave the patient infertile.

"Men can bank sperm before they have cancer treatment if they hope to have biological children later in their lives. But that is not an option for young boys who haven't gone through puberty, can't provide a sperm sample and are many years away from thinking about having babies," study senior investigator Kyle Orwig, associate professor in the department of obstetrics, gynecology and reproductive medicine at the University of Pittsburgh School of Medicine, said in a university news release.

Orwig and his colleagues froze sperm-producing stem cells from young and adult male monkeys and then gave the monkeys chemotherapy drugs known to harm fertility. A few months later, each monkey's own sperm-producing stem cells were implanted into his testes.

The implanted stem cells restored production of sperm that successfully fertilized eggs to produce embryos.

The study was published Nov. 1 in the journal Cell Stem Cell.

"Many questions remain to be answered," Orwig said. "Should we re-introduce the [sperm-producing] cells as soon as treatment is over, or wait until the patient is considered cured of his disease or when he is ready to start a family? How do we eliminate the risk of cancer recurrence if we give back untreated cells that might include cancer cells? These are issues we still must work through, but this study does show us the concept is feasible."

Orwig noted that several centers in the United States and other countries are already freezing testicular tissue from young cancer patients in anticipation that new stem-cell-based treatments will someday be available to help them have their own biological children.

Scientists note that research with animals often fails to provide similar results in humans.

More information

The Nemours Foundation has more about the effects of childhood cancer treatment on fertility.

-- Robert Preidt

SOURCE: University of Pittsburgh Medical Center, news release, Nov. 1, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. KRAS gene mutation and amplification status affects sensitivity to antifolate therapy
2. Antibody therapy prevents gastrointestinal damage following radiation exposure in mice
3. Chemotherapy proves life-saving for some leukemia patients who fail induction therapy
4. Immunotherapy for elderly cancer patients finds new promise in drug combination
5. Therapy exploits addiction of leukemia cells
6. Intensity Modulated Radiation Therapy optimal for localized prostate cancer
7. Adding drug to standard chemotherapy provides no survival benefit for older lung cancer patients
8. Study Casts Doubt on Value of Pricey Prostate Cancer Therapy
9. 19th century therapy for Parkinsons disease may help patients today
10. New Psoriasis Drugs Not Much Better Than Standard Therapy, Study Finds
11. Xenotransplantation as a therapy for type 1 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stem Cell Therapy Reversed Chemo-Linked Infertility in Male Monkeys 
(Date:2/12/2016)... ... February 12, 2016 , ... Young ... area, celebrates the beginning of the latest charity campaign in their community enrichment ... art. Donations to this worthy cause are currently being accepted at: http://artexpressioninc.org/ ...
(Date:2/12/2016)... FLA (PRWEB) , ... February 12, 2016 , ... Miami ... dental implants to their Miami dental office. Beginning in January, Miami Dental Specialists ... titanium. Miami Dental Specialists are the first office to be chosen by the dental ...
(Date:2/12/2016)... ... 12, 2016 , ... J Thomas & Associates Insurance Agency, ... to act as Agents of Change in the community, announces a new partnership ... to fulfill immediate needs and help them move into permanent housing. Donations to ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... ... article about foods choices that promote eye health. These articles generally list between ... Water and health advocate Sharon Kleyne endorses every one of these lists and ...
(Date:2/12/2016)... ... 12, 2016 , ... Homeowners now have a next generation ... America‚Äôs leading brand of building products, has improved upon its industry-best array of ... version of the ColorView® Exterior Style and Color Selector. Created expressly for the ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... , Feb. 11, 2016 The primary goal ... future adoption patterns on the usage of liquid biopsy. ... following: - Timeframe of liquid biopsy adoption ... cfDNA and Evs—by organization type - Sample inflow to ... blood, saliva, stool, serum, and so on. - Correlation ...
(Date:2/11/2016)... NEW YORK , Feb. 11, 2016 ... and instruments commonly used in laboratories. These may range ... scale condensers. Laboratory glassware is made from borosilicate glass ... shock. Laboratory plasticware, on the other hand, started gaining ... that it was easier to replace glass with plastic ...
(Date:2/11/2016)... , Feb. 11, 2016  Governor Andrew M. Cuomo ... create 1,400 jobs throughout Western New York ... with the SUNY Polytechnic Institute, includes a major expansion ... in Buffalo , as well as ... facility in Dunkirk . The combined ...
Breaking Medicine Technology: