Navigation Links
Stem Cell Therapy Could Boost Kidney Transplant Success: Study
Date:3/20/2012

By Serena Gordon
HealthDay Reporter

TUESDAY, March 20 (HealthDay News) -- A novel technique that uses a kidney transplant recipient's own stem cells may someday replace or reduce the initial use of anti-rejection medications, new research suggests.

Six months after receiving a kidney transplant, only about 8 percent of people given their own mesenchymal stem cells experienced rejection compared with almost 22 percent of people on the standard anti-rejection drugs, according to the study.

"Mesenchymal stem cells are stem cells that can be differentiated into a variety of cells," explained Dr. Camillo Ricordi, study senior author and director of the Cell Transplant Center and Diabetes Research Institute at the University of Miami Miller School of Medicine.

"If you infuse mesenchymal stem cells at the time of the transplant, you could replace the use of powerful anti-rejection drugs, and maybe replace immunosuppressants altogether," he said. This technique could be used in the transplantation of islet cells (in the pancreas) for people with type 1 diabetes, and for other organ transplants, such as the liver, he added.

The people given their own stem cells also had improved kidney function earlier after transplant, Ricordi said.

Results of the study appear in the March 21 issue of the Journal of the American Medical Association.

One of the biggest remaining hurdles in organ transplantation remains the need for powerful anti-rejection and immune-suppressing medications after the transplant.

"Basically, the way we prevent kidney rejections is by putting you on very powerful anti-rejection drugs and immunosuppressive agents to prevent your cells from attacking the foreign organ," said Dr. Robert Provenzano, chair of the department of nephrology, hypertension and transplantation at St. John Providence Health System in Detroit. "But, the current standard has some problems, like an increased risk of infections and the possibility of creating a cancer."

The body's immune system sends out surveillance cells to protect the body against foreign invaders, such as a bacteria, virus or, in this case, a new organ, Provenzano said. The current method of preventing these cells from attacking the new organ is essentially to destroy the surveillance cells. But mesenchymal cells can naturally suppress those surveillance cells so they don't attack, he said.

To see if this suppression would be enough to prevent rejection, Ricordi and his colleagues, including researchers from Xiamen University in China, recruited 159 people with serious kidney disease who were on dialysis. They ranged in age from 18 to 61.

The study participants all had medically well-matched relatives willing to donate a kidney for transplant.

Each was randomly assigned to receive one of three treatments after transplant. One group got standard treatment with anti-rejection medication (induction therapy) and immune-suppressing medication known as calcineurin inhibitors (CNIs). Another group was infused with their own stem cells and the standard dose of CNIs, while the final group received stem cells plus a lower dose of CNIs (80 percent of the standard dose).

Survival rates for the patients and their new kidney were similar for all three groups at 13 to 30 months, the study found.

But before that, at six months, nearly 21.6 percent of those on standard therapy experienced rejection, compared with 7.5 percent of the stem cell plus standard CNIs, and 7.7 percent in the stem cell plus low-dose CNIs.

Both groups who received stem cells recovered kidney function faster than those on standard therapy. And at one year, the researchers found that the risk of opportunistic infections was reduced by nearly 60 percent in those who got the stem cell treatment.

Provenzano expressed enthusiasm for the new procedure. "I see this as the continued evolution of transplant medicine. It's very exciting to be able to use your own natural cells instead of more toxic medications," he said. He added that more studies are needed to confirm these findings and study long-term effects, but said "the data here appears promising."

Some experts are less impressed. "This is a novel technique, but I don't think it would be regarded as a significant step forward. It was only significant at six months," said Dr. Glyn Morgan, the associate director of transplantation at NYU Langone Medical Center in New York City. And, he added, "It's only a change in the induction protocol. Primary immunosuppressant agents are still used long term."

Other researchers have also been testing the use of stem cells in transplants. The March 7 issue of Science Translational Medicine reported on an attempt to transfer stem cells from the donor to the transplant recipient before transplant, in an attempt to create a hybrid immune system that would accept the new organ. Five of eight patients studied haven't needed medications to suppress their immune systems, according to the study.

Ricordi said perhaps a combination of stem cell therapies might lead to even more effective immune suppression.

More information

Learn more about the immune-suppressing medications used after a kidney transplant from the National Kidney Foundation.

SOURCES: Camillo Ricordi, M.D., director, Diabetes Research Institute, and chief, division of cellular transplantation, University of Miami Miller School of Medicine; Glyn Morgan, M.D., associate director of transplantation, NYU Langone Medical Center, and associate professor, NYU School of Medicine, New York City; Robert Provenzano, M.D., chair, department of nephrology, hypertension and transplantation, St. John Providence Health System, Detroit; March 21, 2012, Journal of the American Medical Association


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Study Explains How Shock Therapy Might Ease Severe Depression
2. Cytori breast reconstruction cell therapy trial results published
3. Study finds expensive procedure no more effective than medical therapy to prevent strokes
4. Estrogen-Only Therapy May Reduce Breast Cancer Risk
5. Internet-based therapy relieves persistent tinnitus
6. New universal platform for cancer immunotherapy developed by Penn-led team
7. A culprit behind brain tumor resistance to therapy
8. How chemotherapy becomes more effective
9. New approach to stroke therapy
10. Researchers find sarcoma tumor immune response with combination therapy
11. Web-Based Therapy May Help Teens With Chronic Fatigue
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stem Cell Therapy Could Boost Kidney Transplant Success: Study
(Date:6/25/2016)... , ... June 25, 2016 , ... Conventional wisdom preaches ... success. In terms of the latter, setting the bar too high can result in ... than just slow progress toward their goal. , Research from PsychTests.com ...
(Date:6/24/2016)... ... ... was in a crisis. Her son James, eight, was out of control. Prone to extreme ... “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was ... other children and say he was going to kill them. If we were driving ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute ... Dr. Barry M. Weintraub as a prominent plastic surgeon and the network’s newest ... world, and the most handsome men, look naturally attractive. Plastic surgery should be ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) ... held on June 20th at the Woodmont Country Club at 1201 Rockville Pike, Rockville, ... dedicated to helping service members that have been wounded in battle and their families. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016 Dehaier Medical Systems Ltd. (NASDAQ: ... markets and sells medical devices and wearable sleep respiratory ... strategic cooperation agreement with Hongyuan Supply Chain Management Co., ... June 20, 2016, to develop Dehaier,s new Internet medical ... Dehaier will leverage Hongyuan Supply Chain,s sales platform to ...
(Date:6/24/2016)... , June 24, 2016 ... Market by Type (Standard Pen Needles, Safety Pen Needles), ... (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, Non-Retail) ... MarketsandMarkets, This report studies the market for the forecast ... to reach USD 2.81 Billion by 2021 from USD ...
(Date:6/24/2016)...  Arkis BioSciences, a leading innovator in the ... cerebrospinal fluid treatments, today announced it has secured ... led by Innova Memphis, followed by Angel Capital ... Arkis, new financing will accelerate the commercialization of ... of its in-licensed Endexo® technology. ...
Breaking Medicine Technology: