Navigation Links
Stem Cell Therapy Disappoints Against Rare Kidney Ailment
Date:9/12/2007

Transplanted cells don't boost AL amyloidosis outcomes, study finds

WEDNESDAY, Sept. 12 (HealthDay News) -- In a disheartening result that confounds existing research, a team in France says a new stem cell therapy for a rare kidney disease is no better than the usual chemotherapy-only approach.

The study "has major limitations and must be interpreted with caution," said Dr. S. Vincent Rajkumar, a professor of medicine at the Mayo Clinic. Still, he said, it conflicts with "a widely held belief" that the stem-cell approach -- combined with aggressive chemotherapy -- is better for some patients.

But there's also some good news. The study doesn't reject the possibility that stem-cell transplants may be a better bet in facilities that specialize in the procedure, Rajkumar added.

The findings are published in the Sept. 13 issue of the New England Journal of Medicine.

AL amyloidosis disease is one of several caused by abnormal proteins that deposit themselves in various organs of the bodies and cause major damage, Rajkumar explained.

An estimated 1,200-3,200 people will develop the condition in the United States each year. The disease is similar to a more common condition called multiple myeloma.

Survival with AL amyloidosis is typically measured in months. The average survival time is a year without an effective treatment, said study lead author Dr. Arnaud Jaccard of the Centre Hospitalier Universitaire in Limoges, France.

But, according to Jaccard, there's plenty of controversy about which treatment is best.

In the new study, researchers followed two groups of 50 patients each. One group received treatment with high-dose chemotherapy (a drug called melphalan) followed by stem cell transplants; the other received standard-dose melphalan-plus-dexamethasone chemotherapy.

The researchers followed the patients for an average of three years to see what happened to them.

The team found no major difference in survival between the two groups.

There are some caveats, however, Rajkumar said. For one, few patients took part in the study, lowering its statistical power. For another, many of the patients who received stem-cell transplants got them at facilities that didn't have much experience in the procedure, which is very complicated, he said.

Considering that, it's possible that treatment with stem-cell treatments may be a better option in some cases, Rajkumar said.

More information

For more on AL amyloidosis, visit the Amyloidosis Support Network.



SOURCES: S. Vincent Rajkumar, M.D., professor, medicine, Mayo Clinic, Rochester, Minn.; Arnaud Jaccard, M.D., researcher, Centre Hospitalier Universitaire, Limoges, France; Sept. 13, 2007, New England Journal of Medicine


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Cancer Doctors Okays Controversial Prostate Therapy
2. Consensus on "Combination Therapy" for Breast Cancer
3. Acupuncture May Help Chemotherapy Side Effects
4. Antioxidants protect health tissue in people undergoing radiation therapy.
5. Distraction therapy found very effective in postoperative patients
6. Gene Therapy shows promise in treating Hemophilia
7. "Make AIDS Therapy affordable" - Physicians demand
8. Acupuncture superseeds massage therapy for short term relief of pain
9. Hormone replacement Therapy a headache
10. Simple Therapy
11. Ovarian cancer in relationship with Hormone therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... 10, 2016 , ... 10 Best Water is excited to announce ... brand owners that topped the list as a result of their commitment to offering ... brand was Tibet 5100, a top notch water company that specializes in providing the ...
(Date:2/10/2016)... , ... February 10, 2016 , ... ... organization, welcomes S.S. Nesbitt as the latest addition to its growing list of ... other locations throughout the Southeast, from Orlando to Huntsville and in between. , ...
(Date:2/10/2016)... ... February 10, 2016 , ... Pediatric ... in their patients. Research shows that the Goal Attainment Scale (GAS) captures 20% ... this challenge and learn more about the Goal Attainment Scale, Education Resources Inc. ...
(Date:2/10/2016)... ... February 10, 2016 , ... IDEX Health & ... PEEK-lined stainless steel (PLS) columns combine the strength of traditional stainless steel with ... of biological samples while operating at ultra-high pressures of 20,000 psi. The higher ...
(Date:2/10/2016)... Washington, DC (PRWEB) , ... February 10, 2016 , ... ... highest level since the start of Medicare Part D a decade ago, according to ... collecting comments from older adults on how they are coping with rapidly rising costs. ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... -- --> --> ... Spectroscopy Market by Industry (Oil & Gas, Petrochemical, Pharmaceutical, Water ... & Mining, and Others), And Geography - Global Forecast ... expected to grow to USD 3.9 Billion by 2020, ... 2020. Browse 82 market data Tables and ...
(Date:2/10/2016)... 10, 2016 A new report from business intelligence provider ... that the Alzheimer,s disease market will more than double from just under $5 ... Annual Growth Rate (CAGR) of 11%. Canada , ... , Spain , the UK, and Japan ... period. --> Canada , France , ...
(Date:2/10/2016)... SANFORD, Fla. , Feb. 10, 2016 ... offerings today with the launch of the Specialty Pharmacy ... is an industry-first, aimed at providing real-world education, discussion ... --> --> ... President and CEO of CSI Specialty Group Suzette DiMascio, ...
Breaking Medicine Technology: