Navigation Links
Stem Cell Marker Controls Pair of Key Cancer Pathways
Date:4/14/2008

Work suggests, but does not prove, that stem cells drive breast cancer formation, researcher says

MONDAY, April 14 (HealthDay News) -- New findings by researchers suggest breast cancer may arise from stem cells and that targeting a certain gene linked to these cells may be a key to treatment.

Researchers from Georgetown University Medical Center report that the Musashi1 (Msi1) gene can flip open two known cancer pathways in mammary cells. The gene had been shown in previous studies to be a stem cell marker in several parts of the body.

The findings were expected to be presented April 14 at the annual meeting of the American Association for Cancer Research (AACR) in San Diego.

"This is the first time any role has been attributed to this gene, and it turns out to be one that is surprisingly powerful," study lead author, Xiaoyang Wang, a postdoctoral fellow at Georgetown's Lombardi Comprehensive Cancer Center, said in a prepared statement.

The study, done in a laboratory setting, shows the Msi1 gene regulates cell signaling in two mammary cells pathways -- Wnt and Notch. Both pathways help regulate stem cell growth, and past studies have tabbed them as critical players in the development of many cancers.

The researchers work also uncovered that Msi1 is expressed in particularly aggressive tumors. This finding fuels a debate among cancer researchers following recent studies indicating stem cells may be the root cause of some cancers.

"It is really critical to understand if stem cells are involved in cancer development, because a lot of therapies used to treat cancer don't target stem cells," study senior author Robert Glazer, a Georgetown professor of oncology and pharmacology, said in a prepared statement. "That may explain why tumors come back."

Wang concluded: "This work suggests, but does not prove, that stem cells drive breast cancer formation. Msi1 might make a good therapeutic target, and we are currently testing ways to interfere with its function in cells to see if it disrupts cancer cell proliferation."

More information

The U.S. National Cancer Institute has more about breast cancer.



-- Kevin McKeever



SOURCE: Georgetown University, news release, April 14, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. UCLA researchers identify markers that may predict diabetes in still-healthy people
2. First biomarker discovered that predicts prostate cancer outcome
3. Penn School of Medicine receives $2.3 million to study biomarkers of cigarette smoke exposure
4. Liver cancer marker could yield blood test for early detection
5. Blood Marker Might Help Spot Early Liver Cancer
6. Radiologists identify early brain marker of Alzheimers disease
7. Study makes progress in zoning in on biomarkers for better colon cancer treatment
8. New Ovarian Cancer Biomarker Research Act Introduced
9. Study shows blood markers can help choose best dose for antiangiogenic drugs
10. Mayo Clinic study points to a possible biomarker for colon cancer in people 50 and under
11. Singulex Announces Presentation on Monitoring of Cardiac Biomarker to Assess Transient Myocardial Ischemia at the American Heart Association Scientific Sessions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... 26, 2016 , ... The MIAMI Institute for Age Management and Intervention celebrates ... MD, ABAARM. Dr. Adonis , Wellness Physician of the MIAMI Institute is certified ... Institute for Functional Medicine. , He also heads up FITTLab, the comprehensive medical testing ...
(Date:5/26/2016)... Paso Robles, CA (PRWEB) , ... May 26, 2016 , ... ... tailor’s bunion (also knowns as a bunionette) treatment was more than humbled by customer ... out of one of their SKU's mid sale. Now that Bunion Bootie has completely ...
(Date:5/26/2016)... CA (PRWEB) , ... May 26, 2016 , ... A ... Valley-based startup, The Dough Bar, has ignited an undeniable buzz in the ... a doughnut. But not just any doughnut.  These doughnuts are packed with 11 grams ...
(Date:5/26/2016)... ... 26, 2016 , ... Metcalf & Associates’ Maureen Metcalf ... experience in leading technology and human resources operations for health care, education, banking, ... be featured on Metcalf’s VoiceAmerica radio show , Innovative Leaders Driving Thriving ...
(Date:5/26/2016)... ... 2016 , ... Dr. LeRoy Perry’s recently authored whitepaper, “Tech Neck and ROI ... billions of users, hundreds of millions of whom are coming into the workplace with ... and common action of looking down at hand-held technology devices (tablets, smartphones) for extended ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... HILDEN , Deutschland und GERMANTOWN, ... Zusammenarbeit mit Therawis bedient ... Entscheidungen bei Brustkrebs   QIAGEN N.V. ... QIA) gab heute bekannt, eine Lizenz- und Entwicklungsvereinbarung ... prädiktiver Assays für die Onkologie eingegangen zu sein. ...
(Date:5/25/2016)... 2016 As illustrated by the ... month, the numbers and momentum of cannabis in the ... the billions, more research and development push the sector ... of Legal Marijuana Markets Report  from from ArcView Market ... of the increase in sector is attributed to adult ...
(Date:5/25/2016)... , May 25, 2016 ... 2016"market research report that provides an overview on ... analysis at various stages, therapeutics assessment by drug ... (RoA) and molecule type, along with latest updates, ... reviews key players involved in the therapeutic development ...
Breaking Medicine Technology: