Navigation Links
Stem Cell Marker Controls Pair of Key Cancer Pathways
Date:4/14/2008

Work suggests, but does not prove, that stem cells drive breast cancer formation, researcher says

MONDAY, April 14 (HealthDay News) -- New findings by researchers suggest breast cancer may arise from stem cells and that targeting a certain gene linked to these cells may be a key to treatment.

Researchers from Georgetown University Medical Center report that the Musashi1 (Msi1) gene can flip open two known cancer pathways in mammary cells. The gene had been shown in previous studies to be a stem cell marker in several parts of the body.

The findings were expected to be presented April 14 at the annual meeting of the American Association for Cancer Research (AACR) in San Diego.

"This is the first time any role has been attributed to this gene, and it turns out to be one that is surprisingly powerful," study lead author, Xiaoyang Wang, a postdoctoral fellow at Georgetown's Lombardi Comprehensive Cancer Center, said in a prepared statement.

The study, done in a laboratory setting, shows the Msi1 gene regulates cell signaling in two mammary cells pathways -- Wnt and Notch. Both pathways help regulate stem cell growth, and past studies have tabbed them as critical players in the development of many cancers.

The researchers work also uncovered that Msi1 is expressed in particularly aggressive tumors. This finding fuels a debate among cancer researchers following recent studies indicating stem cells may be the root cause of some cancers.

"It is really critical to understand if stem cells are involved in cancer development, because a lot of therapies used to treat cancer don't target stem cells," study senior author Robert Glazer, a Georgetown professor of oncology and pharmacology, said in a prepared statement. "That may explain why tumors come back."

Wang concluded: "This work suggests, but does not prove, that stem cells drive breast cancer formation. Msi1 might make a good therapeutic target, and we are currently testing ways to interfere with its function in cells to see if it disrupts cancer cell proliferation."

More information

The U.S. National Cancer Institute has more about breast cancer.



-- Kevin McKeever



SOURCE: Georgetown University, news release, April 14, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. UCLA researchers identify markers that may predict diabetes in still-healthy people
2. First biomarker discovered that predicts prostate cancer outcome
3. Penn School of Medicine receives $2.3 million to study biomarkers of cigarette smoke exposure
4. Liver cancer marker could yield blood test for early detection
5. Blood Marker Might Help Spot Early Liver Cancer
6. Radiologists identify early brain marker of Alzheimers disease
7. Study makes progress in zoning in on biomarkers for better colon cancer treatment
8. New Ovarian Cancer Biomarker Research Act Introduced
9. Study shows blood markers can help choose best dose for antiangiogenic drugs
10. Mayo Clinic study points to a possible biomarker for colon cancer in people 50 and under
11. Singulex Announces Presentation on Monitoring of Cardiac Biomarker to Assess Transient Myocardial Ischemia at the American Heart Association Scientific Sessions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... ... The American public tends to feel uncomfortable about drinking recycled waste water ... well water. The recent experience with lead contaminated water in Flint, Michigan, according to ... increasing public acceptance of recycled waste water as drinking water. , The Flint ...
(Date:2/5/2016)... ... ... Boar’s Head Brand®, one of the nation’s leading providers of premium delicatessen foods, ... out of your party preparation – follow these easy, yet delicious recipes with the ... , “The key to hosting a successful game-day party is creating a flavorful menu ...
(Date:2/5/2016)... (PRWEB) , ... February 05, 2016 , ... Dr. Justin ... announce their 2nd Annual No Cost Dental Day to individuals in need. The event ... purpose of this No Cost Dental Day is to provide dental care to community ...
(Date:2/5/2016)... ... ... Colorize is a web theme package created exclusively for Final ... dynamic moving camera. Colorize is perfect for personal and web related videos and its ... to 5 focus points per scene, stage floor scene presets that are great for ...
(Date:2/5/2016)... ... February 05, 2016 , ... California Mobile Kitchens ... debut of their latest mobile kitchen model, featuring customizable stainless steel interiors and ... commercial kitchens for use anywhere in the U.S. Many of their units can ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... -- Site Profile: --> ... Speech Recognition People, announced their latest primary healthcare case study where ... turnaround times and to save the practice money. Site ... Challenge: --> ,- Wirral CCG ,- VoicePower ... doctors ,- Wirral CCG ,- VoicePower client since 2013 ...
(Date:2/4/2016)... 2016  Edwards Lifesciences Corporation (NYSE: EW ), ... disease and critical care monitoring, announced today that it ... with Morgan Stanley & Co. LLC to repurchase $325 ... of the Company,s previously authorized program to repurchase up ... --> --> Under ...
(Date:2/4/2016)... , Feb. 4, 2016  SciClone Pharmaceuticals, Inc. ... it has entered into a settlement agreement with ... fully resolving the SEC,s investigation into possible violations ... the terms of the settlement agreement, SciClone has ... including disgorgement, pre-judgment interest and a penalty.  This ...
Breaking Medicine Technology: