Navigation Links
Stem Cell Breakthrough May Lead to MS Treatments
Date:4/9/2009

t if they added one of two proteins, FGF2 or SHH, to the cells' growth media, they could reliably induce those cells to become oligodendrocytes. The human application was obvious: ESC-derived oligodendrocytes could either be used directly as a cell therapy for MS and related diseases, or serve as research tools to study them.

But, when Dr. Su-Chun Zhang of the University of Wisconsin, Madison, who has been studying oligodendrocytes and myelination for nearly a quarter-century, tried to apply the culture conditions painstakingly worked out in rodents to human cells, oligodendrocytes failed to emerge.

"When we expand these [rodent] progenitor cells with FGF2 (and another factor called PDGF), these progenitor cells will become oligodendrocytes," Zhang said. But, "What we discovered was that when we did [the experiment] in the same way with human progenitor cells, they were blocked in this process."

By carefully dissecting the molecular events that occur as human ESCs differentiate first into neural stem cells, then neural progenitor cells, then pre-oligodendrocytes, and finally mature oligodendrocytes, Zhang and his team identified the source of the difference: While both rodents and humans control the process with the same regulatory circuitry and use the same molecules (including both FGF2 and SHH), FGF2 behaves differently in each species.

In mice, FGF2 promotes oligodendrocyte maturation; in humans, it inhibits the process.

"This finding is actually quite significant scientifically," said Zhang, "because even [though] the transcriptional network is more or less the same, yet they respond to the same factor in an opposite way. To me, that's quite extraordinary."

Once that simple fact was understood, the experiment could be tweaked so that human embryonic stem cells could, in fact, generate oligodendrocytes.

The study, said Coetzee, "just reinforces the absolute importance of being able to do
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Breakthrough model for human cancer may improve development of cancer drugs; study in PNAS
2. Hypnotherapy Breakthrough: Renowned Smoking Cessation Specialist Helps To Stop Smoking In One Session
3. Revolutionary Breakthrough in Lip Augmentation: Valencia Plastic Surgeon offers Permanent Lip Implants as Injectible Alternative
4. Saving Vaccines with SensoTech's Breakthrough in Vaccine Temperature Monitoring
5. Blue Highway Selects Invention Machine Goldfire to Fuel Product Pipeline and Sustain Breakthrough Innovation
6. Breakthrough Solution Found in Refresh Skin Care Products
7. Aesthera Announces Breakthrough Innovations at 2009 American Academy of Dermatology (AAD) Meeting
8. TB breakthrough could lead to stronger vaccine
9. Prosthetic Center of Excellence to Provide Breakthrough Technology to Rehabilitation Patients
10. Neurologist to Announce Breakthrough Headache Treatment
11. Nutrition 21 Launches Breakthrough Weight Management Product: Iceland Health(R) Appetite Control Formula
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stem Cell Breakthrough May Lead to MS Treatments
(Date:8/1/2015)... (PRWEB) , ... August 01, 2015 , ... Have you ever wondered what “Karma” really ... you hear the word “Karma.” , Vedic tradition, which gave birth to Hinduism, is ... one of the central concepts of this tradition. According to the wisdom of this heritage, ...
(Date:8/1/2015)... ... ... Brig and Lita Hart, icons of the network marketing industry and founders of ... the HOPE Movement of EvolvHealth. In what has been a long-term relationship between the ... their missions of purpose together to change the course of the network marketing industry. ...
(Date:8/1/2015)... ... August 01, 2015 , ... BeverlyD, owner and founder of BeverlyD Luxe ... the very first small business donation to kick off the campaign for healing and ... Her legacy includes a complete line of raw, organic hair care products, as well ...
(Date:7/31/2015)... Vegas, NV (PRWEB) , ... July 31, 2015 , ... Ticket Down is a reputable ... Vegas at the MGM Grand Garden Arena. Fans of every genre of music will ... Friday, September 18th, the first day of the festival, the following artists will perform: ...
(Date:7/31/2015)... ... 31, 2015 , ... Ticket Down is a reliable source for authentic tickets ... Grant Park. The festival will end on Sunday, August 2nd. , ... annual Lollapalooza. This unique and unbelievably popular festival attracts the best in entertainment ...
Breaking Medicine News(10 mins):Health News:Nithyananda Yoga Foundation to Conduct Global Webinar on Karma at No Charge on August 1st 2Health News:Looking for HOPE? Healthy Home Has Evolv’d 2Health News:Looking for HOPE? Healthy Home Has Evolv’d 3Health News:March4thforWellBeing Foundation Kickoff 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 3Health News:Cheap 2015 Lollapalooza Tickets: Ticket Down Slashes Ticket Prices on Lollapalooza Tickets at Grant Park in Chicago for Saturday, August 1st and Sunday, August 2nd 2
... are spending hundreds of millions annually to prevent dry skin... much of ... steps can be taken to heal and protect the skin. , ... ... time of the year for scores of people across the country suffering ...
... University School of Medicine and the University of East Anglia ... diabetic drugs doubles the risk of fractures in women with ... on the Web site for the Canadian Medical Association ... , "We knew going into this study that there was ...
... Minn., Dec. 9 Here are highlights from the December issue ... publication as often as you wish. Mayo Clinic Women,s ... for a fee. Include the following subscription information as your editorial ... information, 800-876-8633, extension 9751. , , ...
... WASHINGTON, Dec. 9 Trust for America,s Health (TFAH) Executive Director ... Committee on Health, Education, Labor, and Pensions hearing on "Prevention and ... , The hearing will be held at ... , , "TFAH believes that a ...
... Dec. 9 Dr. Stephen Joffe, Craig Joffe, and,Alan ... with the U.S.,Securities and Exchange Commission. The group ... Inc. (Nasdaq: LCAV ), which,operates 77 LasikPlus ... United States. Dr. Joffe is the founder and ...
... trials fail to confirm suspected benefit, , , TUESDAY, Dec. ... C won,t prevent men from getting prostate cancer. , ... public health implications, the results of two large randomized, ... a cancer-prevention benefit, despite past findings that seemed to ...
Cached Medicine News:Health News:Top Tips To Naturally Heal Dry Skin And Moisturize This Winter 2Health News:Top Tips To Naturally Heal Dry Skin And Moisturize This Winter 3Health News:Popular class of diabetes drugs doubles risk of fractures in women 2Health News:Popular class of diabetes drugs doubles risk of fractures in women 3Health News:December 2008 Mayo Clinic Women's HealthSource Highlights Happiness, Dementia and Smoking 2Health News:December 2008 Mayo Clinic Women's HealthSource Highlights Happiness, Dementia and Smoking 3Health News:December 2008 Mayo Clinic Women's HealthSource Highlights Happiness, Dementia and Smoking 4Health News:December 2008 Mayo Clinic Women's HealthSource Highlights Happiness, Dementia and Smoking 5Health News:TFAH to Testify at Congressional HELP Committee Hearing on Prevention and Public Health on Dec. 10 2Health News:LCA-Vision's Former Executive Management Urge Board of Directors to Immediately Call Special Shareholder Meeting to Approve Poison Pill 2Health News:LCA-Vision's Former Executive Management Urge Board of Directors to Immediately Call Special Shareholder Meeting to Approve Poison Pill 3Health News:LCA-Vision's Former Executive Management Urge Board of Directors to Immediately Call Special Shareholder Meeting to Approve Poison Pill 4Health News:LCA-Vision's Former Executive Management Urge Board of Directors to Immediately Call Special Shareholder Meeting to Approve Poison Pill 5Health News:LCA-Vision's Former Executive Management Urge Board of Directors to Immediately Call Special Shareholder Meeting to Approve Poison Pill 6Health News:Selenium, Vitamins E and C Won't Prevent Prostate Cancer 2Health News:Selenium, Vitamins E and C Won't Prevent Prostate Cancer 3
(Date:7/30/2015)... Calif. , July 30, 2015 Edwards Lifesciences ... science of heart valves and hemodynamic monitoring, today announced that ... Board of Directors. "Bob is an ardent champion ... a true privilege to have him on Edwards, board as ... Mussallem , Edwards, chairman and CEO.  "Bob has provided a ...
(Date:7/30/2015)... (NYSE: RMD ) today announced results for its ... was $453.1 million, a 9 percent increase compared with ... increase on a constant currency basis).  Net income was ... 2014.  Diluted earnings per share for the quarter were ... The results for the quarter ended ...
(Date:7/30/2015)... July 30, 2015  Unichem Pharmaceuticals ( USA ... of Hydrochlorothiazide tablets 25 mg 1000-count bottle to the ... precautionary measure due to the identification of a Clopidogrel ... The risk associated with mistakenly taking a ... increased probability of experiencing Clopidogrel,s side effects which include ...
Breaking Medicine Technology:ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 2ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 3ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 4ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 5ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 6ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 7ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 8ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 9ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 10ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 11ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 12ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 13ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 14ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 15ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 16Unichem Pharmaceuticals (USA), Inc. Issues a Voluntary Nationwide Recall of Hydrochlorothiazide Tablets Due to the Potential Presence of Foreign Tablets 2
... NEWTON, Mass. , Aug. 5 Microfluidics International Corporation (OTC Bulletin Board: ... on Tuesday, August 10, 2010 , at 8:30am ET . , ... (Logo: http://photos.prnewswire.com/prnh/20090811/NE59652LOGO ) , , ... ) , , , ...
... 5 Cornerstone Therapeutics Inc. (Nasdaq: ... specialty pharmaceutical company focused on acquiring, developing and commercializing ... today announced that its product candidate CRTX-067 is an ... mg hydrocodone polistirex suspension product that will be a ...
Cached Medicine Technology:Microfluidics International Corporation to Report Second Quarter 2010 Financial Results on August 10, 2010 2Microfluidics International Corporation to Report Second Quarter 2010 Financial Results on August 10, 2010 3Microfluidics International Corporation to Report Second Quarter 2010 Financial Results on August 10, 2010 4Cornerstone Therapeutics Announces Development of Generic for Tussionex® 2Cornerstone Therapeutics Announces Development of Generic for Tussionex® 3
... standard in corneal diagnostics. Precise Display ... membrane, stroma, Bowman's membrane and epithelial ... Broad Applications in Surgery and Pathology. ... evaluation, endothelial cell analysis, haze detection, ...
... appearance of photo-aged skin, removes age spots ... and broken capillaries. This innovative new application ... pigmentary sun damage through a process called ... and the Nd:YAG Laser is optimized for ...
... affordable lenses available in a variety ... available in prescription powers for those ... "Plano" for those who don't. They ... technology. Incredibly comfortable, 10 fun, eye-catching ...
Each jet black lens features a mesmerizing thin white line that spirals toward the center of the pupil....
Medicine Products: