Navigation Links
Stem Cell, Bone Marrow Transplants Both Benefit Leukemia Patients
Date:2/1/2010

Little difference in survival found 10 years after therapies, study says

MONDAY, Feb. 1 (HealthDay News) -- Long-term survival rates are similar for leukemia patients who've had either peripheral blood stem cell (PBSC) or bone marrow transplants, a new European study says.

The study began with 329 leukemia patients who received either PBSC or bone marrow transplants from a matched sibling donor between 1995 and 1999. Detailed information was collected on all the patients who survived longer than three years after their transplant.

Ten years after transplantation, 49.1 percent of PBSC recipients and 56.5 percent of bone marrow transplant recipients were still alive. Chronic graft versus host disease was more common among PBSC transplant patients (73 percent) than among bone marrow transplant patients (54 percent), and more PBSC recipients needed immunosuppressive treatment five years after transplantation (26 percent vs. 12 percent). But this did not affect the PBSC recipients' general health status or their ability to return to work, the study found.

The researchers also noted a trend toward improved, but not statistically significant, leukemia-free survival and overall survival after bone marrow transplant in patients with acute leukemias. Among patients with acute lymphoblastic leukemia, 10-year leukemia-free survival probability was 28.3 percent in the bone marrow transplant group, compared with 13 percent in the PBSC transplant group.

In patients with acute myeloid leukemia, the rates were 62.3 percent for bone marrow transplant and 47.1 percent for PBSC transplant. For patients with chronic myeloid leukemia, the rates were 40.2 percent for bone marrow transplant and 48.5 percent for PBSC transplant.

"This update comparing two important stem cell sources did not find differences in survival after 10-year follow-up. However, subgroup analyses did reveal notable differences in survival in patients with acute leukemias between those who received allogeneic blood cells and those who received bone marrow, while no differences were seen in patients with chronic myeloid leukemia, the researchers wrote.

"Our observations support previous reports that different patient groups might still benefit from transplantation with bone marrow," they concluded.

The study was published online Jan. 31 in The Lancet Oncology.

More information

The U.S. National Cancer Institute has more about leukemia.



-- Robert Preidt



SOURCE: The Lancet Oncology, news release, Jan. 31, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Anti-Aging/Genetic Health Leader Suracell, Inc. Expands Internationally
2. ACell, Inc. Founder Mentioned on the Oprah Winfrey Show as Inventor of Powder for Healing Severed Fingers
3. StemCor Systems Receives FDA Clearance for Bone Marrow Harvesting System
4. Study on Plasma-Depleted Cord Blood Transplantation Receives Best Abstract Award From The National Marrow Donor Program
5. Oral drug sets a new survival standard for bone marrow cancer
6. Bone marrow cell transplants help nerve regeneration
7. StemCor Systems Announces Acquisition of Intellectual Property to Enhance Bone Marrow Aspiration Platform
8. Transplanted Bone Marrow Cells Aid Nerve Regeneration
9. Stem cells make bone marrow cancer resistant to treatment
10. Saturn Celebrates 11 Years of Helping Save Lives Through Blood, Marrow, Organ and Tissue Donation
11. New Interventional Radiology Treatment Shows Hope for People With Complications from Bone Marrow, Stem Cell Transplants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... 2016 , ... A recent article published June 14 on E ... goes on to state that individuals are now more comfortable seeking to undergo not ... as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... ... is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and ... that call for a minimum wage raise to $12 an hour by 2020 and then ... will restore the lost value of the minimum wage, assure the wage floor does not ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... OAKLAND, N.J. , June 24, 2016 /PRNewswire/ ... in the design, development and manufacturing of collagen ... and regeneration announced today that Bill Messer ... Sales and Marketing to further leverage the growing ... surgery medical devices. Bill joins the ...
(Date:6/24/2016)... , June 24, 2016 The Academy ... of recommendations that would allow biopharmaceutical companies ... with entities that make formulary and coverage decisions, a ... "value" of new medicines. The recommendations address ... not appear on the drug label, a prohibition that ...
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ... company developing innovative inhaled drugs, announced today that it ... Russell Investments reconstituted its comprehensive set of U.S. ... "This is an important milestone for Pulmatrix," said ... increase shareholder awareness of our progress in developing drugs ...
Breaking Medicine Technology: