Navigation Links
'Stealth' properties of cancer-causing genetic mutations identified
Date:2/21/2012

Scientists have discovered that cancer-causing genetic mutations have better-disguised electronic signatures than other mutations - a trait which could help them fly under the radar of the body's defence mechanisms.

Results of a new study by physicists at the University of Warwick and in Taiwan hint at the possibility that one day the electronic properties of DNA could play a role in early diagnosis and detection of mutation hotspots.

Researchers drew on the power of supercomputers to model every possible mutation for 162 disease-related genes, a total of 5 billion calculations.

When they compared the models with medical databases of real-life mutations known to have caused cancer in individuals, they found that the real-life mutations had a "stealthier" electronic structure than the theoretical mutations which didn't have a documented real-life counterpart.

These disease-causing mutations caused a smaller change in the electronic structure of the DNA molecule, which may make them less detectable to the cell's damage repair process at work on a molecular level .

Professor Rudolf Roemer from the Department of Physics at the University of Warwick said: "We studied the scale of change in electronic charge transport for pathogenic mutations when compared to all possible mutations.

"We found that those mutations which had the smallest change in electronic properties correspond to those mutations which we know to have caused cancer in real life.

"You could compare these disease-causing mutations to planes that use stealth technology to go undetected by defence systems like radar.

"Similarly the real-life mutations that show up in the medical databases are likely to be the ones that didn't have a sufficiently dramatic effect on the structure of the DNA when they first appeared, which is why they were not spotted and repaired early on by the body's molecular defence mechanisms.

"It seems
'/>"/>

Contact: Anna Blackaby
a.blackaby@warwick.ac.uk
44-247-657-5910
University of Warwick
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Bisexual men: When sexual health requires stealth
2. Plankton inspires creation of stealth armor for slow-release microscopic drug vehicles
3. New drug uses stealth to stop cancer cell reproduction
4. Nanoscale stealth probe slides into cell walls seamlessly, say Stanford engineers
5. Led by advances in chemical synthesis, scientists find natural product shows pain-killing properties
6. Protective properties of green tea uncovered
7. Compound enhances cancer-killing properties of agent in trials
8. Natural Cayenne Pepper Soap Boasts Anti-Aging Properties for an Instant Facelift
9. New research reinforces anti-inflammatory properties of tart cherries
10. Adaptogenic Properties of Tahitian Noni Bioactive Beverages Revealed
11. Ensemble Healthcare Properties Purchases North Valley Medical Plaza
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2015)... ... August 27, 2015 , ... According to the Rocky ... patient with hemophilia is $175,000. Hemophilia is an inherited, life-long condition with no ... RMHBDA exists to help raise funds for patients suffering from bleeding disorders, deliver ...
(Date:8/27/2015)... CA (PRWEB) , ... August 27, 2015 , ... According ... and the American Heart Association have released new guidelines to educate doctors and patients ... last update to these particular guidelines came in 2007, so the new version is ...
(Date:8/27/2015)... , ... August 27, 2015 , ... ... , is one of just 20 adult-only medical centers in the United States ... with failing hearts and lungs. The Extracorporeal Life Support Organization (ELSO) , ...
(Date:8/27/2015)... ... August 27, 2015 , ... About 10 percent of mothers ... Gulf Coast, killing more than 1,800 people, displacing hundreds of thousands and causing ... University study. , While most people don’t develop persistent depression after a major ...
(Date:8/27/2015)... ... August 27, 2015 , ... Infocast is ... October 27-29, 2015 in San Jose, CA. The first event dedicated to ... the void that exists where battery development and energy storage innovation are concerned. ...
Breaking Medicine News(10 mins):Health News:Avitus Group Encourages Business & Employee Community Involvement; Senior Level Staff Leads Way With Support of Rocky Mountain Hemophilia & Bleeding Disorders Association 2Health News:Avitus Group Encourages Business & Employee Community Involvement; Senior Level Staff Leads Way With Support of Rocky Mountain Hemophilia & Bleeding Disorders Association 3Health News:Avitus Group Encourages Business & Employee Community Involvement; Senior Level Staff Leads Way With Support of Rocky Mountain Hemophilia & Bleeding Disorders Association 4Health News:Article on New Diabetic Care Guidelines Shines Brightly on Weight Loss Surgery, notes Beverly Hills Physicians 2Health News:Article on New Diabetic Care Guidelines Shines Brightly on Weight Loss Surgery, notes Beverly Hills Physicians 3Health News:International Organization Honors Allegheny General Hospital's Advanced Lifesaving Program for Cardiac and Respiratory Failure 2Health News:International Organization Honors Allegheny General Hospital's Advanced Lifesaving Program for Cardiac and Respiratory Failure 3Health News:International Organization Honors Allegheny General Hospital's Advanced Lifesaving Program for Cardiac and Respiratory Failure 4Health News:About 10 Percent of Mothers Experienced Depression Two Years After Hurricane Katrina, New Study Shows 2Health News:Infocast Hosting First Conference Dedicated to Powering Wearable Devices & the IoT 2
... growing epidemic of the world,s most common heart rhythm ... admissions in Australia, according to cardiology researchers. A ... University of Adelaide and the Cardiovascular Research Centre at ... to atrial fibrillation had more than tripled in Australia ...
... Elsevier, a world-leading publisher of scientific, technical ... the launch of SciVerse, an innovative platform that ... scientific community to collaborate on the development of ... to releasing the APIs (application programming interfaces) for ...
... available in French . The medicinal use ... the public at large for many years as an alternative ... be effective and may have unwanted side effects. A new ... researchers provides evidence that cannabis may offer relief to patients ...
... , SUNDAY, Aug. 29 (HealthDay News) -- Having a particular ... risk of getting migraines, new research shows. While migraines ... specific genes has proven difficult, the researchers said. The ... genetic variant associated with a heightened risk for the most ...
... cannabis reduces pain, improves mood and helps sleep, ... Medical Association Journal) (pre-embargo link only) http://www.cmaj.ca/embargo/cmaj091414.pdf ... pain due to damage or dysfunction of the ... include opioids, anticonvulsants, antidepressants and local anesthetics, but ...
... Portugal: Many children are being put at risk by ... fever, coughs and colds, says a study from Australia to ... Federation (FIP) today (Monday 30 August). The ... Sydney, New South Wales, say that dosing errors and inappropriate ...
Cached Medicine News:Health News:Heart disorder hits national epidemic proportions 2Health News:Elsevier introduces SciVerse, an innovative platform for accelerating science 2Health News:Research demonstrates benefits of medical cannabis as a treatment for chronic pain 2Health News:New Migraine Gene Discovered 2Health News:New Migraine Gene Discovered 3Health News:Smoked cannabis reduces chronic pain 2Health News:Widespread parental misuse of medicines puts children at risk 2Health News:Widespread parental misuse of medicines puts children at risk 3
(Date:8/27/2015)... CardioVascular Institute enrolled the first patient in Pennsylvania ... in a trial assessing the safety and effectiveness ... main artery of the leg. The new stent allows for ... stent fracture or re-narrowing after the stent is placed. ... the BioMimics 3D Stent System and will enroll 280 subjects ...
(Date:8/27/2015)... NEW YORK , Aug. 27, 2015   ... cord tissue , and placenta tissue ... innovative cord blood banking e-commerce website. This new website ... than ever with an interactive shopping cart and checkout ... "Most cord blood banking websites make this ...
(Date:8/27/2015)... 2015  Lightwave Logic, Inc. (OTCQB: LWLG), a ... Generation Photonic Devices and Non-Linear Optical Polymer ... fiber-optic data communications and optical computing, announced today ... appointed to the Company,s Board of Directors. ... optoelectronics is widely recognized with wide-ranging experience across ...
Breaking Medicine Technology:First Pennsylvania Patient Treated in Landmark Vascular Study 2Cord Blood Bank Revolutionizes Process of Online Cord Blood Banking 2Lightwave Logic Announces the Appointment of Optoelectronics Industry Leader, Michael Lebby, Ph.D. to its Board of Directors 2Lightwave Logic Announces the Appointment of Optoelectronics Industry Leader, Michael Lebby, Ph.D. to its Board of Directors 3
... /PRNewswire-Asia-FirstCall/ -- China Botanic Pharmaceutical Inc. (AMEX: ... manufacturer and distributor of botanical products, bio-pharmaceuticals and traditional ... made considerable progress in its efforts to comply with ... ("SOX 404") for fiscal year 2010. As ...
... Inc. (Nasdaq: PARD ), a biopharmaceutical company ... has completed the voluntary prepayment of the $12.35 million ... secured loan facility with GE Business Financial Services Inc. ... 16, 2010 that it had provided notice of such ...
Cached Medicine Technology:China Botanic Announces Progress on its SOX 404 Compliance Program 2China Botanic Announces Progress on its SOX 404 Compliance Program 3Poniard Pharmaceuticals Completes Voluntary Prepayment of Term Loans and Secures New Committed Equity Financing Facility 2Poniard Pharmaceuticals Completes Voluntary Prepayment of Term Loans and Secures New Committed Equity Financing Facility 3Poniard Pharmaceuticals Completes Voluntary Prepayment of Term Loans and Secures New Committed Equity Financing Facility 4
Aerosolized Medication Device for Infants. An alternative to aerosol blow-by., ,The PediNeb™ was designed to enhance the delivery of aerosolized medication, while reducing the apprehension enc...
... and Respiratory Products, ,Westmed designs, manufacturers ... Anesthesia and Respiratory professionals. Our mission is ... the clinician's ability to deliver quality medical ... bottom line. , ,Our web site ...
... Applications:, ,Cool Aerosol Therapy. Replaces air ... devices such as aerosol masks, face tents, ... only limited FIO2 and limited flow. The ... against accidental dilution with room air or ...
... For use with metered dose inhalers., ... medication from MDI canisters. Its versatile design ... ventilator circuit, in conjunction with an endotracheal ... oral inhalation. ACE may also be used ...
Medicine Products: