Navigation Links
'Stealth' properties of cancer-causing genetic mutations identified
Date:2/21/2012

Scientists have discovered that cancer-causing genetic mutations have better-disguised electronic signatures than other mutations - a trait which could help them fly under the radar of the body's defence mechanisms.

Results of a new study by physicists at the University of Warwick and in Taiwan hint at the possibility that one day the electronic properties of DNA could play a role in early diagnosis and detection of mutation hotspots.

Researchers drew on the power of supercomputers to model every possible mutation for 162 disease-related genes, a total of 5 billion calculations.

When they compared the models with medical databases of real-life mutations known to have caused cancer in individuals, they found that the real-life mutations had a "stealthier" electronic structure than the theoretical mutations which didn't have a documented real-life counterpart.

These disease-causing mutations caused a smaller change in the electronic structure of the DNA molecule, which may make them less detectable to the cell's damage repair process at work on a molecular level .

Professor Rudolf Roemer from the Department of Physics at the University of Warwick said: "We studied the scale of change in electronic charge transport for pathogenic mutations when compared to all possible mutations.

"We found that those mutations which had the smallest change in electronic properties correspond to those mutations which we know to have caused cancer in real life.

"You could compare these disease-causing mutations to planes that use stealth technology to go undetected by defence systems like radar.

"Similarly the real-life mutations that show up in the medical databases are likely to be the ones that didn't have a sufficiently dramatic effect on the structure of the DNA when they first appeared, which is why they were not spotted and repaired early on by the body's molecular defence mechanisms.

"It seems they are able to use stealth tactics which may allow them to go undetected by the body's defence systems making them all the more dangerous in their ability to then go on and cause a disease like cancer."

Dr Stephen Wells of the Department of Physics at the University of Warwick added: "This is the first time scientists have identified a link between mutations and the electronic properties of disease-related genes.

"Although it is obviously very early days, these findings suggest that we could one day use these differences in electronic signatures as a red flag in terms of early detection of diseases like cancer."

The paper, The Interplay of mutations and electronic properties in disease-related genes, is published in the open access journal Scientific Reports.

It is co-authored by Chi-Tin Shih and Yun-Yin Cheng of Tunghai University and Ching-Ling Hsu of Chung-Yuan Christian University in Taiwan.


'/>"/>

Contact: Anna Blackaby
a.blackaby@warwick.ac.uk
44-247-657-5910
University of Warwick
Source:Eurekalert

Related medicine news :

1. Bisexual men: When sexual health requires stealth
2. Plankton inspires creation of stealth armor for slow-release microscopic drug vehicles
3. New drug uses stealth to stop cancer cell reproduction
4. Nanoscale stealth probe slides into cell walls seamlessly, say Stanford engineers
5. Led by advances in chemical synthesis, scientists find natural product shows pain-killing properties
6. Protective properties of green tea uncovered
7. Compound enhances cancer-killing properties of agent in trials
8. Natural Cayenne Pepper Soap Boasts Anti-Aging Properties for an Instant Facelift
9. New research reinforces anti-inflammatory properties of tart cherries
10. Adaptogenic Properties of Tahitian Noni Bioactive Beverages Revealed
11. Ensemble Healthcare Properties Purchases North Valley Medical Plaza
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... , ... February 11, 2016 , ... Florida Hospital presents ... take on the St. Louis Blues at the Amalie Arena. The puck drops at ... walk-through heart exhibit, the MEGA Heart, prior to the game. The MEGA Heart will ...
(Date:2/11/2016)... , ... February 11, 2016 , ... ... reverse diabetes has been gearing up for their simultaneous grand openings in March. ... about right now that you’re probably wondering, is reversing diabetes possible? According to ...
(Date:2/11/2016)... ... February 11, 2016 , ... veEDIS Clinical Systems, LLC, ... highly adaptable algorithms, has been updated to help Emergency Department physicians and nurses ... with Zikas and a travel history to affected regions, or potential exposure through ...
(Date:2/11/2016)... FL (PRWEB) , ... February 11, 2016 , ... ... the commencement of a master charity program created to assist the people of ... days, working closely with nonprofit organizations and community leaders. Their hope is to ...
(Date:2/11/2016)... ... ... Dickinson Insurance & Financial Services continues their commitment to act as Agents ... local boy named Barrett, who has been fighting ALL leukemia for almost two years. ... all local families dealing with childhood cancer. Information on how to help is now ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... -- Walgreens has committed to provide drug disposal kiosks ... D.C. as part of a program to combat ... advocacy organization As You Sow. Conrad MacKerron , ... on to unneeded drugs because they lack easily accessible collection ... --> Conrad MacKerron , Senior Vice President at As ...
(Date:2/11/2016)... Ga. , Feb. 11, 2016  MiMedx Group, ... company utilizing human amniotic membrane and other birth tissues, ... platforms to develop and market advanced products and therapies, ... Capital Markets, 2016 Global Healthcare Conference in ... Chairman and CEO, Michael J. Senken , Chief ...
(Date:2/11/2016)... de 2016  A Proliant Biologicals anuncia, com ... bovina (BSA -- Bovine Serum Albumin ) ... Norte da Nova Zelândia, em Feilding. ... da Proliant nos EUA, localizada em ... dos equipamentos foram feitos de forma a reproduzir ...
Breaking Medicine Technology: