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Statins reduce loss of function, keeping old lungs young - even in smokers
Date:10/12/2007

ed that effect, the researchers also divided their subjects into four smoking groups: never-smokers, long-ago quitters, recent quitters and current smokers. Within each smoking group, those not taking statins were estimated to experience faster declines in FEV1 and FVC than those taking statins, wrote Dr. Schwartz, noting that the size of the effect varied a bit with smoking status.

Our results suggest (weakly) that long-term quitters and recent quitters may be able to benefit more from statin use than other groups, Dr. Schwartz wrote.

But because of overlap between groups and the lack of randomization and controls in this study, the researchers point out that further data is needed before any definitive conclusions are drawn. Their findings do, however, support the hypothesis that statins reduce the annual loss of lung function that occurs with age.

The researchers suggest that the observed effect may be attributable to statins ability to reduce inflammation and smoking-induced injury in the lung, as well as their capacity to reduce serum levels of C-reactive protein, which relates to systemic inflammation, and to protect against oxidative damage.

The research adds to a growing body of knowledge indicating the positive effects of statin use beyond its cholesterol lowering properties.


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Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

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