Navigation Links
Statins may protect against kidney complications following elective surgery
Date:4/14/2011

Taking a statin before having major elective surgery reduces potentially serious kidney complications, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN).

Each year, more than 230 million major elective surgeries are performed around the world. Unfortunately, many patients who undergo major operations develop kidney injury soon after surgery, often due to decreased blood flow to the kidneys and/or the effects of inflammation.

Animal studies suggest that the cholesterol-lowering drugs called statins protect the kidneys from such damage, but whether a similar benefit occurs in humans is uncertain. To investigate, Amber Molnar, MD (University of Western Ontario and Lawson Health Research Institute, in London, Canada), Amit Garg, MD, PhD (University of Western Ontario and Lawson Health Research Institute, in London; and the Institute for Clinical Evaluative Sciences, in Toronto, Canada) and their colleagues conducted a population-based retrospective study of all older patients who underwent major elective surgery in the province of Ontario, Canada from 1995 to 2008. Surgeries included cardiac, thoracic, vascular, intra-abdominal, and retroperitoneal procedures.

A total of 213,347 patients from 211 hospitals underwent major elective surgery, and 4,020 patients (1.9%) developed postoperative kidney injury within two weeks of surgery. A total of 1,173 patients (0.5%) required dialysis within two weeks of surgery, and 5,974 patients (2.8%) died within a month of surgery.

Prior to surgery, 67,941 patients (32%) were taking a statin. Patients taking a statin were 20% less likely to develop kidney injury, need dialysis, and die compared to patients who were not taking a statin. Also, there was evidence of a dose-effect, with patients on higher potency statins having less kidney injury. In addition, statins were beneficial whether they were started greater than 90 days or less than 30 days prior to surgery.

"Our study suggests that statin use in older persons results in less kidney injury following major elective surgery and reduces the risk of premature death after surgery," said Dr. Molnar. She added that the results warrant further investigation with more rigorous studies, but such trials will be difficult to carry out. "Conducting randomized controlled trials to examine whether statins are protective against definitive renal outcomes, such as acute dialysis, will be logistically challenging given that the need for acute dialysis is a relatively rare event," she said.


'/>"/>

Contact: Shari Leventhal
sleventhal@asn-online.org
202-416-0658
American Society of Nephrology
Source:Eurekalert

Related medicine news :

1. Statins make radiation more effective at curing prostate cancer
2. Statins Might Help HIV Patients, Study Suggests
3. Blood Protein Level May Not Influence Effectiveness of Statins
4. Statins May Be Harmful After Stroke
5. Statins OK for Patients With Abnormal Liver Function: Study
6. Statins Dont Reduce Colon Cancer Risk, Study Finds
7. Statins did not reduce colorectal cancer in WHI analysis
8. Statins dont prove useful for general pediatric lupus population
9. Aspirin, Statins May Reduce Problems After Heart Surgery
10. Statins May Guard Against Rheumatoid Arthritis
11. Study Suggests Statins Could Help Some With Normal Cholesterol
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... , ... “Vintage and Harvest A Cultivation of Christian Love” is the creation ... North Carolina with his wife, Anna Marie. He and his wife are the proud ... also the author of “Shadow and Substance.” , “Love, the agape kind, is seen ...
(Date:3/23/2017)... ... 2017 , ... In 2016 the World Health Organization declared the Zika virus ... Zika-related cases in the Americas within the next year. Lyme disease is one of ... skyrocketing to an estimated 329,000. Yet, Zika, Lyme and other insect borne illnesses are ...
(Date:3/23/2017)... ... March 23, 2017 , ... Demonstrating ... communities, 16 more public health departments have been awarded national accreditation through the ... million people into the expanding network of communities across the nation whose health ...
(Date:3/23/2017)... ... March 23, 2017 , ... The IoT (Internet of Things) is ... making a huge impact on businesses and individual consumers alike. Laboratories can maximize ... have a value anywhere from $4 trillion to $11 trillion dollars by the year ...
(Date:3/23/2017)... , ... March 23, 2017 ... ... financial services firm serving the families and businesses of the Norwalk and ... program. Northern Ohio Recovery Center (N.O.R.A.) is a nonprofit, community-based substance abuse ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... March 24, 2017 ShangPharma, a ... and cost-effective drug development and discovery services, ... biotechnology industry, announced today the intent for ... will be consolidating the Contract Research Organizations ... Shanghai ChemPartner. These entities include ChemPartner Shanghai, ...
(Date:3/24/2017)... India , March 24, 2017 A ... market has been growing rapidly as the global sales of Adcetris ... the growth in the antibody drug conjugates market is driven by ... of cancer and wider therapeutic window offered by ADCs. ... Browse 3 Tables and 94 ...
(Date:3/24/2017)... , March 24, 2017  Eli Lilly and ... plans to invest $850 million in its U.S. ... across its U.S. enterprise, including research laboratories, manufacturing ... are being driven by demand for Lilly products, ... medicines in development targeting cancer, pain, diabetes and ...
Breaking Medicine Technology: