Navigation Links
Statins may increase risk of interstitial lung abnormalities in smokers
Date:1/5/2012

ween ILA and cardiovascular medications or disorders were detected. The association between statin use and ILA was greatest with statins with higher hydrophilicity (readily absorbed or dissolved in water), such as pravastatin, and in higher age groups.

The effects of statins on lung injury and fibrogenesis were also examined in a study in mice, which were pretreated with pravastatin prior to intratracheal bleomycin administration. Statin use was found to exacerbate bleomycin-induced lung fibrosis. In a further in vitro study, statin pretreatment was shown to enhance Nlrp3-inflammasome activation through mitochondrial reactive oxygen species generation in macrophages. "These results implicate activation of the NLRP3 inflammasome in fibrotic lung disease," said Jin-Fu Xu MD, and Augustine M. K. Choi, MD, of the Department of Pulmonary Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, in Shanghai, China and the Division of Pulmonary and Critical Care at Brigham and Women's Hospital in Boston, respectively.

There were some limitations to both studies. Findings in the mouse model were not replicated in human samples. All study subjects were current or former smokers, perhaps limiting the applicability of the results to others. Cigarette smoking by itself may lead to pulmonary inflammation. Finally, the duration and dosage of statin therapy was not available for the majority of patients.

"While statin use was associated with ILA in our study, caution should be used when extrapolating these findings to the care of patients," concluded Dr. Hunninghake. "The significant benefits of statin therapy in patients with cardiovascular disease probably outweigh the risk of developing ILA, and statin use may benefit some patients with respiratory disease. Clinicians should be aware, though, that radiological evidence of ILD can develop in some patients treated with statins."


'/>"/>

Contact: Nathaniel Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

1

GOOD

Page: 1 2

Related medicine news :

1. Could Statins Help Those Hospitalized With Flu?
2. Statins may reduce mortality in patients hospitalized with influenza
3. High Doses of Statins Tied to Less Arterial Plaque in Study
4. Statins Dont Raise Risk of Brain Bleeds After Stroke: Study
5. Statins reduce deaths from infection and respiratory illness, 8 years on from trial
6. Statins May Help Heart in Some Young Stroke Patients
7. Statins Dont Seem to Raise Cancer Risk
8. High-Dose Statins May Increase Diabetes Risk
9. Statins may protect against kidney complications following elective surgery
10. Statins make radiation more effective at curing prostate cancer
11. Statins Might Help HIV Patients, Study Suggests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... (PRWEB) May 21, 2013 DISCcert has ... showing how to use 17 DISC applications at the ... a natural progression. , The July 25 & 26th ... top 17 ways of applying DISC. The time-tested, proven ... graduates. The user-friendly DISC training materials ; ...
(Date:5/21/2013)... 21, 2013) Prostaglandin analogues (PGAs), drugs which lower ... for people with glaucoma, but their use is not ... vision, dryness, changes in eye color and other side ... drugs also cause upper and lower eyelid drooping and ... are described in PLOS ONE . , Researchers ...
(Date:5/21/2013)... Mecklenburg EMS Agency (Medic) and ... free Community Wellness Fair to educate the public on health ... held on Wednesday, May 22, 2013 from 4:00 pm until ... Old Mallard Creek Road, Charlotte, NC 29262). , ... the Mecklenburg County Department of Social Services are ...
(Date:5/21/2013)... 2013, Paris, France: One-year results from SOURCE XT ... (TAVI) registries to-date reported today at EuroPCR 2013 ... high rates of device success for all access approaches, ... Post-Approval Study followed up 2688 consecutively enrolled patients (mean ... heart valve at 93 centres in 17 countries between ...
(Date:5/21/2013)... Angeles, CA (PRWEB) May 21, 2013 According ... “Time to Rethink the Use of Botox,” Botox ... world since their approval in 2002 (Go to goo.gl/8iYbD). Although ... become quite popular with men. The injection makes facial wrinkles ... single Botox injection last for about three months. This means ...
Breaking Medicine News(10 mins):Health News:DISCcert Offers 17 Applications in Coming DISC Certification 2Health News:DISCcert Offers 17 Applications in Coming DISC Certification 3Health News:DISCcert Offers 17 Applications in Coming DISC Certification 4Health News:Glaucoma drug can cause droopy eyelids 2Health News:Mecklenburg EMS Agency Teams Up with the YMCA of Greater Charlotte and Others to Educate the Public on Health Related Initiatives 2Health News:Botox – Is the World’s Most Popular Cosmetic Procedure Safe? 2
... Minority Quality Forum Launches First U.S. HIV/AIDS Atlas , ... today launched a groundbreaking HIV/AIDS Atlas ( http://www.MapHIV.org ... epidemic in communities across the United States. The Atlas ... location for the first time, painting a comprehensive picture of ...
... Perfect Time for Fitness! , , LOS ANGELES, June 22 ... in the park or along the beach. Now a brand new ... fitness equipment on wheels, but with a unique design to allow ... a new concept of fitness, will be introduced to California starting ...
... , DentaBurst(TM) delivers an on-the-go oral care solution to ... NEW YORK, June 22 Crown Consumer Brands today ... the original proven technology will remain intact, an improved, ... will accompany this highly anticipated re-launch. , ...
... MUSCLEPHARM(R) LLC, the rising star of the Sports Nutrition ... through each of Vitamin Shoppe,s 400+ locations nationwide. , ... launch of our entire line of products," MUSCLEPHARM president ... athletes in nearly every neighborhood across the nation! Vitamin ...
... Transcend Medical, Inc., an ophthalmic device company dedicated ... announced today that it has closed a $35 million ... of its Transcend CyPass(TM) System, a novel proprietary system ... Lead investor HLM Venture Partners, along with other new ...
... Magnetic Resonance Center of the University Children,s Hospital ... in MR-guided, non-invasive neurosurgery. Ten patients have been ... ultrasound. This fully non-invasive procedure opens new horizons ... brain disorders. In the context of a ...
Cached Medicine News:Health News:MapHIV.org Shows 18% of Georgia's Counties are Seriously Impacted by HIV 2Health News:MapHIV.org Shows 18% of Georgia's Counties are Seriously Impacted by HIV 3Health News:Pumgo Fitness Scooter Will Highlight Venice Beach This Summer 2Health News:Crown Consumer Brands Re-Launches DentaBurst(TM) Freshening Teeth Cleaners 2Health News:MUSCLEPHARM Products Hit Vitamin Shoppe Shelves With a Bang! 2Health News:Transcend Medical Raises $35 Million Series B Round Towards Development of Novel Glaucoma Treatment 2Health News:Successful neurosurgery with transcranial MR-guided high-intensity focused ultrasound 2Health News:Successful neurosurgery with transcranial MR-guided high-intensity focused ultrasound 3
(Date:5/21/2013)... N.J. , May 21, 2013 ... company, today announced that 13-year veteran ... Executive Officer. Geraghty,s experience includes more than 20 ... management positions with manufacturing organizations. He succeeds ... after serving as Kepner-Tregoe,s Chairman of the Board ...
(Date:5/21/2013)... 2013  IsoRay, Inc. (AMEX: ISR ), ... into an exclusive international distribution agreement with IASIS Medical ... Greece . IsoRay is a medical ... radioisotope applications for brain cancer, lung cancer, head and ... IASIS Medical is ideally suited to support ...
(Date:5/21/2013)... Inc. (OTC BB: VASO) (the "Company"), a diversified medical technology ... devices and in the domestic sale of diagnostic imaging products, ... President and CEO of Vasomedical, Inc. will present at the ... 2013 in New York City at ... is scheduled to begin at 9:30 a.m. EDT. ...
Breaking Medicine Technology:Kepner-Tregoe, Inc. Promotes Chris Geraghty to Chief Executive Officer 2Kepner-Tregoe, Inc. Promotes Chris Geraghty to Chief Executive Officer 3IsoRay Announces A New International Distributor For Greece 2IsoRay Announces A New International Distributor For Greece 3Vasomedical, Inc. To Present At The Second Annual Marcum LLP MicroCap Conference 2
... Va., Sept. 20, 2011 Rock Creek Pharmaceuticals, a ... ), announced that on September 19, 2011 a utility ... Office ("PTO"). This utility patent application is based on ... various products containing anatabine and the administration of anatabine ...
... Sept. 20, 2011 /PRNewswire-Asia/ -- Chindex International, Inc. (NASDAQ: ... providing health care services in China through the operations ... care hospitals and affiliated ambulatory clinics, today announced that ... to be held October 13-14, 2011 at Nomura,s Singapore ...
Cached Medicine Technology:Rock Creek Pharmaceuticals Discloses Further Anatabine Patent Filing 2Rock Creek Pharmaceuticals Discloses Further Anatabine Patent Filing 3Rock Creek Pharmaceuticals Discloses Further Anatabine Patent Filing 4
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: