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Statins have potential to treat an autoimmune clotting disorder called antiphospholipid syndrome
Date:11/10/2012

were matched for sex and age. Nine of the 12 proteins were elevated in aPL-positive patients compared to healthy controls.

The researchers then set out to test whether a statin called fluvastatin could reduce the proteins that were elevated in the individuals with aPLs. "Statins do more than just lowering cholesterol. They also have anti-inflammatory effects," said Dr. Pierangeli. The 41 aPL-positive patients were given 40 mg of fluvastatin daily for three months and then were instructed to stop taking the drug. Investigators collected blood samples and measured the levels of the inflammatory and thrombotic proteins at baseline and monthly thereafter for six months.

Of the 24 patients who completed the study, the researchers found that fluvastatin significantly decreased the levels of eight of the 12 proteins, all of which had been elevated in aPL-positive individuals compared with controls. The investigators also found that when patients stopped taking the fluvastatin, the levels of six proteins rebounded to high levels.

"Following Dr. Pierangeli's mouse experiments in which statins decreased inflammatory proteins induced by aPL, this is the first prospective study analyzing these proteins in aPL-positive patients before and after treatment with fluvastatin," said Dr. Erkan. "Launching a randomized trial to determine the effect of statins on clinical outcomes is the logical next step."

"An Open-Label Prospective Pilot Mechanistic Study of Fluvastatin in Persistently Antiphospholipid Antibody-Positive Patients" will be presented on Nov. 13 at 3 p.m. ET. Other authors involved in the study are JoAnn Vega from Hospital of Special Surgery; and Rohan Willis, M.D., Vijaya Murthy, M.D., Gurjot Basra, M.D., Emilio Gonzalez, M.D., Ana Laura Carrera Marin, and Patricia Ruiz Limon from the University of Texas Medical Branch, Galveston, Texas.


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Contact: Phyllis fisher
phyllis.fisher@gmail.com
212-606-1724
Hospital for Special Surgery
Source:Eurekalert

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