Navigation Links
Statins did not reduce colorectal cancer in WHI analysis
Date:11/8/2010

PHILADELPHIA The use of statins among a group of postmenopausal women did not reduce the risk for colorectal cancer, according to the results of a prospective analysis of data from the large population-based Women's Health Initiative (WHI).

"The results of our study are consistent with the majority of the literature suggesting no significant reduction in colorectal cancer risk among users of statins," said Michael S. Simon, M.D., professor of oncology in the department of oncology at Wayne State University and Barbara Ann Karmanos Cancer Institute, Detroit.

Simon presented these study results at the Ninth Annual AACR Frontiers in Cancer Prevention Research Conference, held here from Nov. 7-10, 2010.

According to Simon, the results from several case-control studies have shown a moderate reduction in colorectal cancer risk in people who use statins. However, a majority of the literature researching the association, including data from randomized controlled trials and cohort studies, show no association between statin use and reduced colorectal cancer risk.

"Colorectal cancer is the third leading cause of cancer incidence and death in the United States," he said. "While regular screening has been shown to be effective in decreasing mortality, the majority of the population receives no screening, or inadequate screening, which supports the need to focus on chemoprevention to lower death rates."

One method of colorectal cancer chemoprevention being researched is the use of statins. In this study, Simon and colleagues used data from the WHI to determine if there was a link between colorectal cancer prevention and statins. The study included 159,219 postmenopausal women aged 50 to 79 years. There were 2,000 cases of colorectal cancer identified during an average of 10 years of follow-up.

Women participating in the study were asked to bring all medications to their screening interviews and the use of any statin, or other lipid-lowering medication, was entered into the WHI database. About 8 percent of women in the study were using statins.

The yearly rate of colorectal cancer did not differ between women taking statins and those not taking statins. There was also no difference in risk for colorectal cancer based on the duration of statin use, type of statin, statin potency or use of other lipid-lowering medications. In addition, the researchers identified no link between statin use and tumor location, stage, grade or histology.

According to Simon though, the effect of statins on colorectal cancer risk deserves some additional study in certain patient populations.

"A recent study suggested a possible greater effect of statins in reducing both cardiovascular and colorectal cancer risk among individuals with a genetic variation of the enzyme inhibited by statins," he said. "This finding suggests that future studies should focus on individuals at high risk based on family history or genetic predisposition."


'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Statins dont prove useful for general pediatric lupus population
2. Aspirin, Statins May Reduce Problems After Heart Surgery
3. Statins May Guard Against Rheumatoid Arthritis
4. Study Suggests Statins Could Help Some With Normal Cholesterol
5. Statins, Painkillers May Upset PSA Test Results
6. Some on Statins May Not Need Boost in Good Cholesterol
7. Statins May Not Be as Helpful for Those Without Heart Disease
8. Statins May Lower Rates of Prostate Cancer Recurrence
9. Statins associated with lower cancer recurrence following prostatectomy
10. MSU team studies connection between statins, tendon ruptures
11. Too Many Stroke Patients Go Without Statins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2017)... ... July 21, 2017 , ... Roderick ... planning services to families and business owners in northern Florida, is joining the ... provide support to area adults with developmental challenges. , The First Coast YMCA ...
(Date:7/21/2017)... ... July 21, 2017 , ... Hospital M&A activity slowed in the second ... of hospital acquisitions rose to 23 in the second quarter, up 15% from the ... the 20 announced deals in the year-ago second quarter. Only four of the transactions ...
(Date:7/21/2017)... ... July 21, 2017 , ... MedMatchPlus+ has launched ... of acceptance to a residency in a United States hospital. Being accepted into ... U.S. , According to data released by the ECFMG®, every year, 50 percent ...
(Date:7/21/2017)... ... July 21, 2017 , ... The most common surgical techniques ... of life five years after injury, according to research presented today at the ... Canada. The study followed patients for five years following surgery. , “Orthopaedic surgeons ...
(Date:7/20/2017)... July 20, 2017 (PRWEB) , ... ... ... Technologies, a global provider of enterprise-grade IT operations analytics and application performance ... of one of world’s largest healthcare services providers. , According to Peter ...
Breaking Medicine News(10 mins):
(Date:7/10/2017)... , July 10, 2017  US medical equipment and ... 2021, according to Medical Equipment & Supplies: ... Freedonia Focus Reports. Continued increases in demand for medical ... of the population and supported by gains in disposable ... and supplies. New product introductions will also drive sales ...
(Date:7/10/2017)... -- The tenth annual BioPharm America™ will take ... the Sheraton Boston Hotel, September 26–27. The event will ... makers and innovative biotech startup companies. The event is ... impactful days. BioPharm America is now part of Biotech ... with 4,500+ life science industry influencers participating in 8+ ...
(Date:7/5/2017)... 2017 Wolfmet 3D  printed tungsten collimator manufactured by M&I ... manufacturing combine to progress molecular radiotherapy imaging. In ... unable to accurately quantify the radiation absorbed by those patients ... success of this radiotherapy treatment has been available — that ... ...
Breaking Medicine Technology: