Navigation Links
Statins alter prostate cancer patients' PSA levels
Date:4/28/2009

Beyond lowering cholesterol, statin medications have been found to have numerous other health benefits, including lowering a healthy man's risk of developing advanced prostate cancer, as well as lowering his prostate-specific antigen (PSA) levels.

But a new study by researchers at Henry Ford Hospital finds that statins also can lower PSA levels in men with prostate cancer, potentially altering the results of a patient's PSA test and masking his risk for prostate cancer.

"We found that PSA levels are actually significantly lower in prostate cancer patients on statins versus prostate cancer patients not on statins," says study lead author Piyush K. Agarwal, M.D., an urologist at Henry Ford Hospital. "The implication is that we may need to lower our PSA threshold for performing a biopsy in patients on statins, as statins may decrease the amount of measurable PSA."

Dr. Agarwal and his colleagues will present the results from their study Tuesday, April 26 at the American Urological Association's annual meeting in Chicago.

A PSA test which measures PSA levels in a man's blood along with a digital rectal exam are most frequently used to help screen for prostate cancer in men age 50 or older. Increased PSA levels can often signal benign prostate conditions or prostate cancer.

Previous studies have shown that statins can lower absolute PSA levels in healthy men. Until now, however, there have been no studies that looked at the effect of statins on patients with prostate cancer.

In a review of 3,828 patients undergoing robotic-assisted lapraroscopic prostatectomy at Henry Ford Hospital from January 2001 to July 2008, Dr. Agarwal and his colleagues identified 1,031 patients who were taking statins prior to surgery.

Those patients were then compared against patients not taking statins preoperatively to measure PSA levels based on age, BMI and Gleason score, a classification of the grade and stage of prostate cancer.

The study revealed that PSA levels were lower in patients taking statins prior to surgery. This difference was statistically significant and also present based on various age ranges studied. For overweight patients (BMI 25-30) using statins, PSA levels were found to be lower compared to patients not taking these medications.

PSA levels, however, were not significantly lower in patients taking statins for Gleason 6 and Gleason 8-10, but were for those with Gleason 7 disease. Gleason 7 disease accounted for the majority of cancers in the study group, with 57 in the statin group and 54 percent in the non-statin group.


'/>"/>

Contact: Dwight Angell
dwight.angell@hfhs.org
313-850-3471
Henry Ford Health System
Source:Eurekalert

Related medicine news :

1. Statins Guard Against Prostate Cancer
2. Statins may exert influence on prostate cancer growth by reducing inflammation
3. Many Who Should Use Statins Dont
4. Statins May Help Before Artery-Opening Surgery
5. Study Finds Millions More May Benefit From Statins
6. 6.5 million more patients might benefit from statins to prevent heart attacks, strokes
7. Statins lower stroke severity, improve recovery
8. Dallas Scientists Discover Statins May Falsely Indicate Thyroid Problems
9. Statins Pay Off on a Health-Policy Level, UCSF Study Finds
10. Not Many U.S. Kids Need Statins
11. Taking Statins Faithfully Lengthens Life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... , ... January 23, 2017 , ... ... high-quality general gynecological care and gynecological services for women of all ... care for a wide variety of reproductive services from routine health screenings to ...
(Date:1/23/2017)... ... ... “Crossing the Bar”: a moving and eloquent drama depicting the events that happen ... creation of published author, Charlotte Hotte, a North Carolina native, a mother of two, ... book to her sister, Denise, wishes to acknowledge her savior, Jesus Christ, along with ...
(Date:1/23/2017)... ... January 23, 2017 , ... “Life Under Blankets”: ... from an early age. “Life Under Blankets” is the creation of published author, Kimberly ... Circle Campus in Chicago. She went on to pursue a master’s degree in education ...
(Date:1/23/2017)... ... ... Day is a time when many people celebrate romance and love by giving cards, candy, ... the ideal present, Atlanta-based Perimeter Plastic Surgery is offering a Valentine’s Day special: ... and get $50 free. , “A lot of people just buy the more predictable ...
(Date:1/22/2017)... ... 2017 , ... Zifam Pinnacle, an Australian company dedicated to providing a unique ... buyers at the January ECRM Trade Show in Hilton Head, SC. , Zifam Pinnacle ... in all of its creations to help create a more traditional and natural approach ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... , January 23, 2017 Longer life expectancy and ... the global market for medical device technologies. BCC Research reveals ... Asia-Pacific region, should see strong growth due to ... disposable incomes. Continue Reading ... ...
(Date:1/23/2017)... 2017  ResMed (NYSE : RMD), BMC (Pékin, Chine) et ... aujourd,hui qu,ils se sont mis d,accord sur le règlement ... BMC et 3B seront autorisés à vendre leurs produits ... et ResMed effectuera le paiement de la décision en ... de Floride entre les deux parties. Le règlement n,inclut ...
(Date:1/23/2017)... Spain , January 23, 2017 /PRNewswire/ ... biopharmaceutical company focused on treatments for calcification disorders, ... enrolled in the Phase IIb "CaLIPSO Study" clinical ... of cardiovascular calcification (CVC) in end-stage-renal-disease (ESRD) patients ... in the last stage of chronic kidney disease, ...
Breaking Medicine Technology: