Navigation Links
Statins alter prostate cancer patients' PSA levels
Date:4/28/2009

Beyond lowering cholesterol, statin medications have been found to have numerous other health benefits, including lowering a healthy man's risk of developing advanced prostate cancer, as well as lowering his prostate-specific antigen (PSA) levels.

But a new study by researchers at Henry Ford Hospital finds that statins also can lower PSA levels in men with prostate cancer, potentially altering the results of a patient's PSA test and masking his risk for prostate cancer.

"We found that PSA levels are actually significantly lower in prostate cancer patients on statins versus prostate cancer patients not on statins," says study lead author Piyush K. Agarwal, M.D., an urologist at Henry Ford Hospital. "The implication is that we may need to lower our PSA threshold for performing a biopsy in patients on statins, as statins may decrease the amount of measurable PSA."

Dr. Agarwal and his colleagues will present the results from their study Tuesday, April 26 at the American Urological Association's annual meeting in Chicago.

A PSA test which measures PSA levels in a man's blood along with a digital rectal exam are most frequently used to help screen for prostate cancer in men age 50 or older. Increased PSA levels can often signal benign prostate conditions or prostate cancer.

Previous studies have shown that statins can lower absolute PSA levels in healthy men. Until now, however, there have been no studies that looked at the effect of statins on patients with prostate cancer.

In a review of 3,828 patients undergoing robotic-assisted lapraroscopic prostatectomy at Henry Ford Hospital from January 2001 to July 2008, Dr. Agarwal and his colleagues identified 1,031 patients who were taking statins prior to surgery.

Those patients were then compared against patients not taking statins preoperatively to measure PSA levels based on age, BMI and Gleason score, a classification of the grade and stage of prostate cancer.

The study revealed that PSA levels were lower in patients taking statins prior to surgery. This difference was statistically significant and also present based on various age ranges studied. For overweight patients (BMI 25-30) using statins, PSA levels were found to be lower compared to patients not taking these medications.

PSA levels, however, were not significantly lower in patients taking statins for Gleason 6 and Gleason 8-10, but were for those with Gleason 7 disease. Gleason 7 disease accounted for the majority of cancers in the study group, with 57 in the statin group and 54 percent in the non-statin group.


'/>"/>

Contact: Dwight Angell
dwight.angell@hfhs.org
313-850-3471
Henry Ford Health System
Source:Eurekalert

Related medicine news :

1. Statins Guard Against Prostate Cancer
2. Statins may exert influence on prostate cancer growth by reducing inflammation
3. Many Who Should Use Statins Dont
4. Statins May Help Before Artery-Opening Surgery
5. Study Finds Millions More May Benefit From Statins
6. 6.5 million more patients might benefit from statins to prevent heart attacks, strokes
7. Statins lower stroke severity, improve recovery
8. Dallas Scientists Discover Statins May Falsely Indicate Thyroid Problems
9. Statins Pay Off on a Health-Policy Level, UCSF Study Finds
10. Not Many U.S. Kids Need Statins
11. Taking Statins Faithfully Lengthens Life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture ... said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package ... Final Cut Pro X . Simply select a ProHand generator and drag it ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van ... Wellness at Work award to iHire in recognition of their exemplary accomplishments in worksite ... 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented its first-ever ... Medicine conference in Ponte Vedra Beach, FL. The awards honor the outstanding work ... Practice and Pediatric Emergency Medicine Practice. , “With this award, we recognize ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 The vast majority of ... dialysis facility.  Treatments are usually 3 times a week, ... visit, including travel time, equipment preparation and wait time. ... especially grueling for patients who are elderly and frail.  ... nursing and rehabilitation centers for some duration of time. ...
(Date:6/23/2016)... , June 23, 2016  Experian Health, ... and transforming the patient payment and care ... innovative new products and services that will ... revenue cycle offerings. These award-winning solutions will ... workflows, remain compliant in an ever-changing environment ...
(Date:6/23/2016)... WASHINGTON , June 23, 2016  The ... Pharmaceuticals has joined the health policy research organization ... Steven Romano , MD, senior vice president and ... his company,s representative on the NPC Board of ... are pleased that Mallinckrodt has joined us in ...
Breaking Medicine Technology: