Navigation Links
Statins Won't Hurt, Might Even Help, Your Pancreas: Study
Date:8/21/2012

By Jenifer Goodwin
HealthDay Reporter

TUESDAY, Aug. 21 (HealthDay News) -- Statins don't raise the risk of pancreatitis, a painful and potentially life-threatening inflammation, a new review finds.

Putting to rest concerns raised by previous research, this new study finds cholesterol-lowering drugs such as Lipitor (atorvastatin) and Zocor (simvastatin) may actually help ward off pancreatitis. The pooled analysis of 21 published and unpublished randomized, controlled trials -- the gold standard of medical research -- found that people taking statins were at 18 percent to 23 percent reduced chance of developing pancreatitis.

Researchers also looked at a class of drugs called fibrates, which doctors prescribe for people with high triglycerides, another type of blood fat. Their analysis found a slight, but statistically insignificant, increase of developing pancreatitis from fibrates.

"Statins seem to carry a previously unrecognized benefit of reducing pancreatitis risk, which actually contradicts what was previously reported in the literature," said senior study author Dr. David Preiss, a physician at the University of Glasgow in Scotland.

The study is published in the Aug. 22/29 issue of the Journal of the American Medical Association.

The pancreas, an organ located behind the stomach, makes digestive enzymes and hormones including insulin.

Prior studies have suggested that statins may increase the risk of pancreatitis, but the new review of data from trials that included more than 150,000 participants found no such connection.

"This data give us confidence we don't need to worry about pancreatitis occurring from statin drugs," said Dr. Robert Eckel, past president of the American Heart Association and a professor of medicine at University of Colorado, in Denver.

Statins work by reducing LDL ("bad") cholesterol, and studies have shown this reduces heart attacks and strokes, he added.

The story with fibrates is more complicated. Fibrates help to reduce triglycerides, an unhealthy blood fat, while boosting HDL ("good") cholesterol. But studies on whether reducing levels of triglycerides using fibrates leads to a reduction in heart attacks and stroke have been mixed, experts said.

And very high triglyceride levels on their own are a risk factor for pancreatitis.

About 1 percent to 3 percent of people who develop pancreatitis die from it, Eckel said. Symptoms of pancreatitis include severe belly pain, nausea, vomiting and fever.

In the review, researchers examined data from seven randomized clinical trials of fibrates that included data on more than 40,000 participants. Patients, who were followed on average for more than five years, had slightly elevated triglyceride levels -- between 145 mg/dL to 184 mg/dL. (Normal is below 150 mg/dL, Eckel said.)

Among those patients, the analysis showed a slightly increased chance of developing pancreatitis while on fibrates, but it wasn't statistically significant.

Based on that finding, the authors said statins appear to be better than fibrates at preventing pancreatitis in people with slightly elevated triglyceride levels.

What's not covered in this review is what effect fibrates would have on people with higher triglycerides. Typically, when Eckel sees patients with very high triglyceride levels (above 1,000 mg/dL), he first puts them on a low-fat diet to bring down the levels to the 500 to 1,000 mg/dL range before prescribing fibrates.

"The fibrate trials gives us a hint that maybe there was a relationship between the fibrates and pancreatitis, but that wouldn't keep us from using fibrates to treat high triglycerides," Eckel said.

Overall, whether they were taking statins, fibrates or placebo, the number of people who developed pancreatitis in the trials was small -- less than 1 percent.

More information

The U.S. Food and Drug Administration has more on statins.

SOURCES: David Preiss, M.D., Ph.D., physician, University of Glasgow, Scotland; Robert Eckel, M.D., past president, American Heart Association and professor, medicine, University of Colorado, Denver; Aug. 22/29, 2012, Journal of the American Medical Association


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Statins prevent cancer in heart transplant recipients
2. Statins May Help Prevent Enlarged Prostate: Study
3. Are Statins Less Helpful for Women?
4. Turning off key piece of genetic coding eliminates toxic effect of statins, SLU research finds
5. Statins Heart Benefits Outweigh Diabetes Risk: Study
6. New Stool Test Might Aid in Early Detection of Colon Cancer
7. Depo-Provera Birth Control Might Raise Breast Cancer Risk
8. Brain Falters Near End of Life, but Games, Puzzles Might Slow Decline
9. Infection Might Raise Blood Clot Risk for Older Adults: Study
10. Anxiety Might Help People Sniff Out Threats
11. Lung Cancer Screening Might Pay Off, Analysis Shows
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Statins Won't Hurt, Might Even Help, Your Pancreas: Study 
(Date:5/26/2016)... ... May 26, 2016 , ... Georgia State University ... specialty academic programs. , Answering to the increasing demand for curricular specializations, the ... law, and environmental and land use law. ,  , “The demand for lawyers ...
(Date:5/26/2016)... ... May 26, 2016 , ... The Woodlands at John Knox ... new model of care for living and healing, celebrated its grand opening, today. The ... a Real Home provided by Empowered Staff. , “This is an incredibly fulfilling time ...
(Date:5/26/2016)... ... May 26, 2016 , ... MadgeTech will be showcasing its line of ... Warner, New Hampshire at the MadgeTech headquarters. With products sold in more than 100 ... government agencies, including NASA. , In 2012, NASA strategically set up 17 RHTemp101A ...
(Date:5/26/2016)... ... ... An April Gallup survey found rising health care costs to be the top ... Living (SHSL) may not share those same worries thanks to a new bundled ... while holding the line on increasing their contributions, including premiums, deductibles and the portions ...
(Date:5/26/2016)... ... May 26, 2016 , ... Leadership ... solutions, today announced the organization has earned its ISO 13485 certification, indicating the ... compliant with all rules and policies associated with ISO quality standard 13485. ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... , May 27, 2016 ... the Dario™ Diabetes Management Tool, today announced that the Company,s ... the Marcum MicroCap Conference being held June 1-2 in ... Invitational, being held June 7-9 in Los Angeles, ... will discuss recent corporate and operational milestones, including the U.S. ...
(Date:5/27/2016)... Amarantus BioScience Holdings, Inc. (OTCQX: AMBS), ... Neurology and Orphan Diseases, today announced that President & CEO ... conferences: SeeThru Equity MicroCap Conference   ... City , NY When: Tuesday, May 31 st ... Where: Grand Hyatt Hotel, 109 East 42 nd ...
(Date:5/26/2016)... TARE (Transarterial Radio-embolization) Using ... and Overall Decreased Use of Hospital Resource ... specialist healthcare company, has today announced the publication ... of ISPOR (International Society for Pharmacoeconomics and Outcomes ... using yttrium-90 glass microspheres is associated with cost ...
Breaking Medicine Technology: