The study findings were to be released this week at the American College of Chest Physicians annual meeting, in San Diego.
Those who had diastolic heart failure and took a cholesterol drug had almost half as much exercise tolerance as those with the condition who didn't take the drugs, the researchers found.
"Some patients with diastolic heart failure may be more prone to the adverse effect of statins on muscle. It may be that patients with particular preexisting factors will experience unfavorable results from statin therapy, including exercise intolerance, dyspnea [shortness of breath], and fatigue," study author Lawrence P. Cahalin, a researcher at Northeastern University, said in a statement.
"Not all statins are alike, and not all patients are alike. Some statins are stronger than others and are likely to act differently, given particular patient characteristics, and produce different degrees of wanted and unwanted effects," Cahalin said. "In our continuing study, we hope to identify patient characteristics that are associated with favorable and less than favorable results from statin therapy."
For now, Cahalin said tests are in order if heart failure patients taking statins suffer from fatigue, shortness of breath and inability to exercise for very long.
In another study to be released at the meeting, researchers report that statins may help prevent blood clots in people with cardiovascular disease.
Previous research has linked atherosclerosis, a condition in which fatty material builds up along artery walls, and venous thrombosis (VTE). Researchers from Albert Einstein Medical Center in Philadelphia, who were investigating the association between statin use and incidence of VTE, reviewed data on 593 patients who were hospitalized for heart attack or ischemic stroke.
"In our study, statin therapy demonstrated a protective effect on this group
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