Navigation Links
Statins May Help Prevent Enlarged Prostate: Study
Date:5/21/2012

MONDAY, May 21 (HealthDay News) -- Statin drugs commonly used to lower cholesterol levels may also slow the unhealthy growth of the prostate in men with elevated blood levels of prostate-specific antigen, a new study finds.

Prostate-specific antigen, or PSA, levels are often elevated due to cancer or other conditions involving the prostate, explained researchers from Duke University Medical Center in Durham, N.C.

The study authors noted that their findings are significant because an enlarged prostate affects up to 90 percent of men older than 70 years and can lead to bladder or kidney damage. Many of these men may already be taking a statin, which include cholesterol-lowering drugs such as Crestor, Lipitor, Pravachol or Zocor.

"Given that prostate enlargement is an important health problem in the United States and elsewhere, and will be a larger problem as the population ages, it's important to understand and treat its causes," the study's lead author, Dr. Roberto Muller, a urology fellow at Duke, said in a medical center news release.

The study, which was funded by drug maker GlaxoSmithKline, is scheduled to be presented Monday at the annual meeting of the American Urological Association in Atlanta.

In the research, Muller and his team sifted through data on more than 6,000 men involved in an unrelated GlaxoSmithKline trial for a prostate cancer drug. The researchers identified over 1,000 men enrolled in the study who also took a statin.

Although the men who took these cholesterol drugs tended to be older and were expected to have enlarged prostates, the study revealed the prostates of these men were similar in size to those who did not take statins.

After two years, the researchers also found that the men who took statins had reduced prostate growth regardless of whether or not they had taken the prostate cancer drug as part of the larger study.

Specifically, prostate growth was an average 5 percent less in men who took both a statin and the prostate cancer drug, compared to the men who only took the cancer medication. For the men taking statins and an inactive placebo pill, prostate growth was about 4 percent less than the men taking only the dummy pill.

The researchers noted, however, the benefits of the drugs seemed to fade after two years.

"We don't yet understand the mechanisms that might be causing this," Muller said in the news release. "Some have suggested that statins may have anti-inflammatory properties, and inflammation has been linked to prostate growth, but this needs further study."

One expert said the findings were interesting, but it's too soon to advise a statin as a preventive measure against enlarged prostate.

"Studies such as these are intriguing because we do not yet know the reason prostates enlarge as men age," said Dr. Warren Bromberg, chief of the division of urology and director of the Prostate Cancer Program at Northern Westchester Hospital Center in Mount Kisco, N.Y. "There are likely multiple factors that may lead to prostate growth, including genetic, environmental, and as the article points out, dietary or behavioral."

The reduction in prostate growth linked to statin use was "small," Bromberg added, and it also seemed temporary.

"Because statins may be associated with significant side effects, I would advise caution in taking such medications strictly to prevent prostate growth," he said.

The study authors noted that men's lifestyles, including diet and exercise, affect their prostate health as well as cholesterol levels. The study was able to show an association between statin use and reduced prostate growth, but it could not prove cause-and-effect.

Still, the findings do shed light on prostate health generally, Muller said.

"Prostate enlargement was once considered an inexorable consequence of aging and genetics, but there is growing awareness that prostate growth can be influenced by modifiable risk factors," he explained. "In this context, the role of blood cholesterol levels and cholesterol-lowering drugs such as statins warrants further study."

Findings presented at medical meetings are typically considered preliminary until published in a peer-reviewed journal.

More information

The U.S. National Library of Medicine has more about enlarged prostate.

-- Mary Elizabeth Dallas

SOURCES: Warren Bromberg, M.D., chief, division of urology and director, Prostate Cancer Program at Northern Westchester Hospital, Mount Kisco, N.Y.; Duke University Medical Center, news release, May 21, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Statins prevent cancer in heart transplant recipients
2. Could Statins Help Prevent Pneumonia?
3. American Heart Association comment: FDA announces safety changes on labeling for some statins
4. Statins linked with lower depression risk in heart patients
5. Its Buyer Beware When Getting Statins Off the Internet
6. Statins May Stave Off Liver Cancer in People With Hepatitis B
7. Study Hints That Statins Might Fight Breast Cancer
8. Why cholesterol-lowering statins might treat cancer
9. Statins May Boost Diabetes Risk in Older Women
10. Statins may increase risk of interstitial lung abnormalities in smokers
11. Could Statins Help Those Hospitalized With Flu?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Statins May Help Prevent Enlarged Prostate: Study 
(Date:8/23/2017)... ... August 23, 2017 , ... Based on worldwide research and ... of HBOT in treating and helping to heal addictions and substance abuse disorders. ... similarities of the wounds to the brain from traumatic brain injuries, and the ...
(Date:8/23/2017)... ... August 23, 2017 , ... PreCheck, Inc., a ... 2017 Inc. 5000 with a three-year sales growth of 49 percent . The ... comprises the most comprehensive look at America’s independent entrepreneurs. This represents PreCheck’s fifth ...
(Date:8/23/2017)... ... August 23, 2017 , ... MobilityWorks ... been named to the 2017 Inc. 500|5000, an exclusive ranking of America’s fastest-growing ... rate of 139 percent, marking the twelfth year that the company has been ...
(Date:8/23/2017)... (PRWEB) , ... August 23, 2017 , ... ... of the American Academy of Orthopaedic Surgeons , points out that therapeutic ... suffering from pain or injury. According to the report, a wider scope of ...
(Date:8/22/2017)... ... 22, 2017 , ... The old adage “you are what ... eating healthy foods. But this well-known piece of nutrition advice ignores that an ... carbohydrates—depends not only on properties of the food but also on properties of ...
Breaking Medicine News(10 mins):
(Date:8/2/2017)... , Aug. 2, 2017  Life Flight Network and PeaceHealth ... agreement improves patient care and operational efficiency for patients at ... , Cottage Grove , and ... transportation. PeaceHealth and Life Flight Network work collaboratively to move ... transport, or when a time sensitive emergency exists. ...
(Date:8/1/2017)... , Aug. 1, 2017   CerSci Therapeutics , ... Dallas, Texas , has received notice from the ... Institutes of Health (NIH) that it has been awarded ... totaling over $650,000 in 2017 with an additional $1,000,000 ... Investigational New Drug application of their lead non-opioid drug ...
(Date:7/31/2017)... Tru-D SmartUVC robots have arrived at Brian Allgood Army Community ... for "Total Room Ultraviolet Disinfection," is a 5-foot-5 germ-killing robot that is ... cleans the area with traditional cleaning protocols. ... Tru-D fights germs at Army hospitals ... "Although the BAACH has a very low infection rate, below national ...
Breaking Medicine Technology: