Navigation Links
Statins May Help Before Artery-Opening Surgery
Date:3/30/2009

Italian studies report fewer heart attacks after procedures ,,

MONDAY, March 30 (HealthDay News) -- Giving statins just before artery-opening angioplasty procedures reduces the incidence of heart attacks and other problems, even for people who already have been taking the cholesterol-lowering drugs, Italian trials show.

It's not the effect that statins have on cholesterol that is responsible for the benefits but rather their ability to reduce inflammation and other problems associated with heart disease, said Dr. Carlo Briguori, a cardiologist at the Clinica Mediterranea in Naples, who was to report the findings Monday at the American College of Cardiology annual meeting, in Orlando, Fla.

His study included 688 people who were having the procedure that cardiologists formally call percutaneous coronary intervention (PCI), in which angioplasty is performed and a stent is then placed in the artery. None had been taking statins before PCI was scheduled. About half of them were give 40 milligrams of atorvastatin (Lipitor) in the 24 hours before the procedure, and the others did not take the drug.

Within 12 hours of the procedure, 15.8 percent of those who were not given a statin had a heart attack, compared with 9.5 percent of those given atorvastatin, Briguori reported.

"This supports the concept that a high loading dose of a statin a day before PCI can have a beneficial effect," he said.

But that trial included only people who had not been taking a statin, and "this patient population is disappearing," said Dr. Germano Di Sciascio, chairman of cardiology at the University of Rome, who reported on a second trial at the meeting. "The vast majority of people who come to the catheterization laboratory are on statins," he said. "In our group, it was 70 percent of patients."

His study included 352 people with heart problems such as stable angina -- chest pain caused by narrowed cardiac arteries -- who had been taking statins. Half of them took 80 milligrams of atorvastatin 12 hours before PCI, with an additional 40 milligrams just before the procedure. The other half took a placebo.

The incidence of major cardiac problems, such as heart attacks, was 48 percent lower in those who took the statin before their procedure, Di Sciascio reported. Blood levels of C-reactive protein, a molecule associated with inflammation, were significantly lower in those who got the statin, he noted, and the drug also acts on clot-forming blood platelet cells and improves the function of the endothelium, the sensitive layer of cells that lines the arteries.

"These findings have the potential to change current clinical practice," Di Sciascio said. "They may support the routine use of statin reloading."

But the trial was relatively small, and its results would have to be repeated in larger studies to justify the routine use of statins before PCI, he said.

More information

The U.S. National Heart, Lung, and Blood Institute has more about statins.



SOURCES: Carlo Briguori, M.D., Ph.D., cardiologist, Clinica Mediterranea, Naples, Italy; Germano Di Sciascio, chairman, cardiology, University of Rome; March 30, 2009, presentations, American College of Cardiology annual meeting, Orlando, Fla.


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Study Finds Millions More May Benefit From Statins
2. 6.5 million more patients might benefit from statins to prevent heart attacks, strokes
3. Statins lower stroke severity, improve recovery
4. Dallas Scientists Discover Statins May Falsely Indicate Thyroid Problems
5. Statins Pay Off on a Health-Policy Level, UCSF Study Finds
6. Not Many U.S. Kids Need Statins
7. Taking Statins Faithfully Lengthens Life
8. Statins Dont Cut Cancer Risk
9. Got High Cholesterol? Statins Are Not the Only Answer, Says Natural Solutions Magazine
10. Millions More Americans Might Be Placed on Statins
11. Statins Help Prevent Delirium After Heart Surgery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Statins May Help Before Artery-Opening Surgery  
(Date:6/25/2016)... , ... June 25, 2016 , ... On Friday, June ... a Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments ... of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott ...
(Date:6/24/2016)... ... 2016 , ... Those who have experienced traumatic events may suffer from a ... such as drug or alcohol abuse, as a coping mechanism. To avoid this pain ... following a traumatic event. , Trauma sufferers tend to feel a range of emotions, ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Scientific Sessions in Dallas that it will receive two significant new grants to ... came as PHA marked its 25th anniversary by recognizing patients, medical professionals and ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented ... in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor the ... Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With this award, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Revolutionary technology includes multi-speaker listening to conquer ... in advanced audiology and hearing aid technology, has today ... world,s first internet connected hearing aid that opens up ...      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) , ... , TwinLink™ - the first dual communication ...
(Date:6/23/2016)... June 23, 2016 The vast majority of ... dialysis facility.  Treatments are usually 3 times a week, ... visit, including travel time, equipment preparation and wait time. ... especially grueling for patients who are elderly and frail.  ... nursing and rehabilitation centers for some duration of time. ...
(Date:6/23/2016)... Tenn. , June 23, 2016 /PRNewswire/ ... automating, integrating and transforming the patient payment ... of several innovative new products and services ... of its revenue cycle offerings. These award-winning ... more efficient workflows, remain compliant in an ...
Breaking Medicine Technology: