Navigation Links
Statins May Help Before Artery-Opening Surgery
Date:3/30/2009

Italian studies report fewer heart attacks after procedures ,,

MONDAY, March 30 (HealthDay News) -- Giving statins just before artery-opening angioplasty procedures reduces the incidence of heart attacks and other problems, even for people who already have been taking the cholesterol-lowering drugs, Italian trials show.

It's not the effect that statins have on cholesterol that is responsible for the benefits but rather their ability to reduce inflammation and other problems associated with heart disease, said Dr. Carlo Briguori, a cardiologist at the Clinica Mediterranea in Naples, who was to report the findings Monday at the American College of Cardiology annual meeting, in Orlando, Fla.

His study included 688 people who were having the procedure that cardiologists formally call percutaneous coronary intervention (PCI), in which angioplasty is performed and a stent is then placed in the artery. None had been taking statins before PCI was scheduled. About half of them were give 40 milligrams of atorvastatin (Lipitor) in the 24 hours before the procedure, and the others did not take the drug.

Within 12 hours of the procedure, 15.8 percent of those who were not given a statin had a heart attack, compared with 9.5 percent of those given atorvastatin, Briguori reported.

"This supports the concept that a high loading dose of a statin a day before PCI can have a beneficial effect," he said.

But that trial included only people who had not been taking a statin, and "this patient population is disappearing," said Dr. Germano Di Sciascio, chairman of cardiology at the University of Rome, who reported on a second trial at the meeting. "The vast majority of people who come to the catheterization laboratory are on statins," he said. "In our group, it was 70 percent of patients."

His study included 352 people with heart problems such as stable angina -- chest pain caused by narrowed cardiac arteries -- who had been taking statins. Half of them took 80 milligrams of atorvastatin 12 hours before PCI, with an additional 40 milligrams just before the procedure. The other half took a placebo.

The incidence of major cardiac problems, such as heart attacks, was 48 percent lower in those who took the statin before their procedure, Di Sciascio reported. Blood levels of C-reactive protein, a molecule associated with inflammation, were significantly lower in those who got the statin, he noted, and the drug also acts on clot-forming blood platelet cells and improves the function of the endothelium, the sensitive layer of cells that lines the arteries.

"These findings have the potential to change current clinical practice," Di Sciascio said. "They may support the routine use of statin reloading."

But the trial was relatively small, and its results would have to be repeated in larger studies to justify the routine use of statins before PCI, he said.

More information

The U.S. National Heart, Lung, and Blood Institute has more about statins.



SOURCES: Carlo Briguori, M.D., Ph.D., cardiologist, Clinica Mediterranea, Naples, Italy; Germano Di Sciascio, chairman, cardiology, University of Rome; March 30, 2009, presentations, American College of Cardiology annual meeting, Orlando, Fla.


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Study Finds Millions More May Benefit From Statins
2. 6.5 million more patients might benefit from statins to prevent heart attacks, strokes
3. Statins lower stroke severity, improve recovery
4. Dallas Scientists Discover Statins May Falsely Indicate Thyroid Problems
5. Statins Pay Off on a Health-Policy Level, UCSF Study Finds
6. Not Many U.S. Kids Need Statins
7. Taking Statins Faithfully Lengthens Life
8. Statins Dont Cut Cancer Risk
9. Got High Cholesterol? Statins Are Not the Only Answer, Says Natural Solutions Magazine
10. Millions More Americans Might Be Placed on Statins
11. Statins Help Prevent Delirium After Heart Surgery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Statins May Help Before Artery-Opening Surgery  
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... ... insurance and financial consultation services to residents in the Sacramento/Folsom region, is initiating ... Chance treatment facility. , The Another Choice Another Chance treatment center in Sacramento ...
(Date:12/7/2016)... ... 07, 2016 , ... A. Kevin Spann Insurance, a New York-based firm offering ... is launching a charity drive to raise funds that will benefit the Marine Corps ... marines and Navy FMF Corpsmen. Working closely with the MCL, the A. Kevin Spann ...
(Date:12/7/2016)... ... ... Facial plastic surgeon, Dr. John D. Rachel of Timeless You™ Chicago , ... local organizations: North Chicago Animal Control and Friends and Our House of Hope Rescue. ... and trained volunteers who support rescued animals held in the City of North Chicago’s ...
(Date:12/7/2016)... ... December 07, 2016 , ... The medical profession is well aware ... One major study analyzing heart attacks among 138,602 people recorded a 35% higher ... year. We would all agree of course–no time of year is a good time ...
(Date:12/7/2016)... ... 2016 , ... Maureen McLaughlin, LA.c., a certified acupuncturist, is ... Connecticut (RMACT). McLaughlin brings nearly 20 years of experience with fertility patients to ... their family building goals. Acupuncture helps fertility patients by supporting the ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... , Dec. 7, 2016 Diplomat Pharmacy, Inc. (NYSE: DPLO) ... subsidiaries—American Homecare Federation, At-Home IV Infusion Professional, BioRx, MedPro Rx, and ... infusion services, visit diplomat.is/specialty-infusion .  ... Diplomat Specialty Pharmacy (PRNewsFoto/Diplomat Pharmacy, ... "As we continue to build on ...
(Date:12/7/2016)... RIDGEFIELD, Conn. , Dec. 7, 2016 According ... survey, in more than one-third (38%) of patients with non-small ... their epidermal growth factor receptor (EGFR) genetic mutation status. The ... abstract ( LBA ID #6067 #P3.02b ) at ... Vienna, Austria . The survey results ...
(Date:12/7/2016)... PUNE, India , December 7, 2016 According ... Component (Services, Software), Delivery Mode, Product Type (Integrated, Standalone), Model (Knowledge-Based), Type ... by MarketsandMarkets, The CDSS Market is expected to reach USD 1,519.2 Million ... 12.2%. Continue Reading ... ...
Breaking Medicine Technology: